Oluwatobi Ayodeji Medayedupin
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View article: Toxicity assessment of 3-<i>O</i>-[6-deoxy-3-<i>O</i>-methyl-β-D-allopyranosyl-(1→4)-β-D-oleandropyranosyl]-17β–marsdenin isolated from<i>Gongronema latifolium</i>leaf on selected brain and kidney function indices in mice
Toxicity assessment of 3-<i>O</i>-[6-deoxy-3-<i>O</i>-methyl-β-D-allopyranosyl-(1→4)-β-D-oleandropyranosyl]-17β–marsdenin isolated from<i>Gongronema latifolium</i>leaf on selected brain and kidney function indices in mice Open
The safety of bioactive compounds, especially those isolated from medicinal plants, is a major concern for health authorities, pharmaceutical industries, and the public. Of recent, anti-tumor pregnane glycosides were isolated from Gongrone…
View article: In silico molecular modeling and simulations of black tea theaflavins revealed theaflavin-3’-gallate as putative liver X receptor-beta agonist
In silico molecular modeling and simulations of black tea theaflavins revealed theaflavin-3’-gallate as putative liver X receptor-beta agonist Open
The low constitutive activation of Liver X receptor, an endogenous nuclear receptor with two subtypes (α and β), is a condition lying at the crossroad of cancer and cardiovascular disease. Both natural and synthetic Liver X receptor agonis…
View article: Selection Of Theaflavin 2B As a Potential HSP90 Antagonist Semi-rigid Ligand Docking Analysis
Selection Of Theaflavin 2B As a Potential HSP90 Antagonist Semi-rigid Ligand Docking Analysis Open
Heat shock protein 90 (HSP90) is an abundant molecular chaperone playing critical role as mediator of proper folding, maturation and stability of diverse client cellular proteins and has been reported to be overexpressed at a level of 2-10…
View article: Tackling the Moving Mutant Target: Taxifolin Derivatives as Novel Putative E571K Exportin-1 Inhibitors for KRAS-mutant Lung Adenocarcinoma Therapy
Tackling the Moving Mutant Target: Taxifolin Derivatives as Novel Putative E571K Exportin-1 Inhibitors for KRAS-mutant Lung Adenocarcinoma Therapy Open
Aim: To establish, through molecular modelling, safe and clinically acceptable putative antagonists of E571K-mutated exportin-1 among the bioactive compounds in various parts of Juglans mandshurica. Methods: The bioactive compounds were su…
View article: Discovery of Eriodictyol as Putative Exportin-1 Inhibitor for Non-small Cell Lung Cancer Therapy
Discovery of Eriodictyol as Putative Exportin-1 Inhibitor for Non-small Cell Lung Cancer Therapy Open
Exportin-1, the ubiquitous nuclear protein transporter, is widely confirmed as an active chemotherapeutic target in non-small cell lung cancer condition while Juglans mandshurica is a well-studied anticancer plant in some lung cancer cell …