Explanipedia

Osteocalcin induces phosphorylation of FOXO1 in human beta-cells and restores insulin expression under hyperglycemic conditions Open

Shubhashish Sarkar, A. Osama Gaber, Christine Beamish, Omaima M. Sabek · 2025

Forkhead box O1 (FOXO1) is a key transcription factor that plays an important role in pancreatic β-cell compensation under physiological and pathological conditions and serves as a key regulator of glucose homeostasis. While FOXO1 expressi…

SPOCK2 controls the proliferation and function of immature pancreatic β-cells through MMP2 Open

Katarzyna Błaszczyk, Anna P. Jedrzejak, Natalia Ziojla, E. G. Shcheglova, Karolina Szarafin , et al. · 2025

Modulation of naïve mesenchymal stromal cells by extracellular vesicles derived from insulin-producing cells: an in vitro study Open

Mahmoud M. Gabr, Sawsan M. El-Halawani, Ayman Refaie, Sherry M. Khater, M. Ismail , et al. · 2024

This study was to determine whether extracellular vesicles (EVs) derived from insulin-producing cells (IPCs) can modulate naïve mesenchymal stromal cells (MSCs) to become insulin-secreting. MSCs were isolated from human adipose tissue. The…

Tead1 reciprocally regulates adult β-cell proliferation and function to maintain glucose homeostasis Open

Jeongkyung Lee, Ruya Liu, Byung S. Kim, Yiqun Zhang, Feng Li , et al. · 2024

Summary Proliferative quiescence in β-cells is required to maintain functional competence. While this presents a significant hurdle in regenerative therapy for diabetes, the molecular underpinnings of this reciprocal relationship remain un…

Tead1 reciprocally regulates adult β-cell proliferation and function to maintain glucose homeostasis Open

Jeongkyung Lee, Ruya Liu, Byung S. Kim, Yiqun Zhang, Feng Li , et al. · 2024

Summary Proliferative quiescence in β-cells is required to maintain functional competence. While this presents a significant hurdle in regenerative therapy for diabetes, the molecular underpinnings of this reciprocal relationship remain un…

Pretransplant HOMA-β Is Predictive of Insulin Independence in 7 Patients With Chronic Pancreatitis Undergoing Islet Autotransplantation Open

Christine Beamish, A. Osama Gaber, Daniel Fraga, Dale J. Hamilton, Omaima M. Sabek · 2022

Background. Islet and β-cell function is intrinsic to glucose homeostasis. Pancreatectomy and islet autotransplantation (PIAT) for chronic pancreatitis (CP) treatment is a useful model for assessing islet function in the absence of immune-…

Human pancreatic microenvironment promotes β-cell differentiation via non-canonical WNT5A/JNK and BMP signaling Open

Jolanta Chmielowiec, Wojciech J. Szlachcic, Diane Yang, Marissa A. Scavuzzo, Katrina Wamble , et al. · 2022

Cognitive and Imaging Differences After Proton and Photon Whole Brain Irradiation in a Preclinical Model Open

Tien T. Tang, Janice A. Zawaski, Shelli R. Kesler, Christine Beamish, Taeko Inoue , et al. · 2021

From Mesenchymal Stromal/Stem Cells to Insulin-Producing Cells: Immunological Considerations Open

Ayman Refaie, Batoul L. Elbassiouny, Małgorzata Kloc, Omaima M. Sabek, Sherry M. Khater , et al. · 2021

Mesenchymal stem cell (MSC)-based therapy for type 1 diabetes mellitus (T1DM) has been the subject matter of many studies over the past few decades. The wide availability, negligible teratogenic risks and differentiation potential of MSCs …

Tead1 reciprocally regulates adult β-cell proliferation and function to maintain glucose homeostasis Open

Jeongkyung Lee, Ruya Liu, Byung S. Kim, Yiqun Zhang, Feng Li , et al. · 2020

Summary Proliferative quiescence in β-cells is required to maintain functional competence. While this presents a significant hurdle in regenerative therapy for diabetes, the molecular underpinnings of this reciprocal relationship remain un…

Tead1 Reciprocally Regulates Adult β-Cell Proliferation and Function to Maintain Glucose Homeostasis Open

Jeongkyung Lee, Ruya Liu, Byung S. Kim, Yiqun Zhang, Feng Li , et al. · 2020

Serum C‐peptide and osteocalcin levels in children with recently diagnosed diabetes Open

Omaima M. Sabek, María J. Redondo, Duc T. Nguyen, Christine Beamish, Daniel Fraga , et al. · 2019

Background We explored the association of C‐peptide (marker of secreted insulin), proinsulin and proinsulin ⁄C‐peptide ratio (PI/C) (markers of beta‐cell endoplasmic reticulum [ER] stress) with undercarboxylated (uOC) and carboxylated oste…

A comprehensive preclinical assessment of late-term imaging markers of radiation-induced brain injury Open

Tien T. Tang, Janice A. Zawaski, Shelli R. Kesler, Christine Beamish, Wilburn E. Reddick , et al. · 2019

Background Cranial radiotherapy (CRT) is an important part of brain tumor treatment, and although highly effective, survivors suffer from long-term cognitive side effects. In this study we aim to establish late-term imaging markers of CRT-…

Islet Identity in Transplantation Procedures: The Intersection of Cellular Maturity and Function Open

Omaima M. Sabek · 2019

Pancreatic islet transplantation holds promise for patients with insulin-dependent diabetes, but is severely limited by a shortage of cadaveric donor islets, and more so because of stringent inclusion criteria for organ donation including …

Cross-sectional evaluation of the relationship between vitamin D status and supplement use across levels of kidney function in adults Open

Linda W. Moore, Wadi N. Suki, Keri E. Lunsford, Omaima M. Sabek, Richard J. Knight , et al. · 2019

Objectives The objective of this study was to assess vitamin D status of US non-pregnant adults using a standardised assay across 15 mL/min/1.73 m 2 increments of kidney function, report the use of dietary supplements containing vitamin D …

Variability in endocrine cell identity in patients with chronic pancreatitis undergoing islet autotransplantation Open

Christine Beamish, A. Osama Gaber, Solmaz Afshar, Daniel Fraga, Dale J. Hamilton , et al. · 2018

Echocardiography Differentiates Lethally Irradiated Whole-Body From Partial-Body Exposed Rats Open

Taeko Inoue, Janice A. Zawaski, Vivien A. Sheehan, Celeste K. Kanne, Alireza Paikari , et al. · 2018

Background: Acute radiation syndrome (ARS) affects morbidity and mortality dependent on the amount of body exposed. We propose the use of echocardiography (EC) to differentiate between survivors and non-survivors by measuring change…

Exercise ameliorates neurocognitive impairments in a translational model of pediatric radiotherapy Open

Iman Sahnoune, Taeko Inoue, Shelli R. Kesler, Shaefali P. Rodgers, Omaima M. Sabek , et al. · 2017

Our data strongly suggest that exercise may be useful in combination with interventions aimed at improving cognitive outcome following pediatric CRT.

Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism Open

Abhisek Mukherjee, Diego Morales‐Scheihing, Natalia Salvadores, Inés Moreno‐González, César González , et al. · 2017

Although a large proportion of patients with type 2 diabetes (T2D) accumulate misfolded aggregates composed of the islet amyloid polypeptide (IAPP), its role in the disease is unknown. Here, we show that pancreatic IAPP aggregates can prom…

Imaging Radiation-Induced Gastrointestinal, Bone Marrow Injury and Recovery Kinetics Using 18F-FDG PET Open

Tien T. Tang, David A. Rendon, Janice A. Zawaski, Solmaz Afshar, Caterina K. Kaffes , et al. · 2017

Positron emission tomography using 18F-Fluro-deoxy-glucose (18F-FDG) is a useful tool to detect regions of inflammation in patients. We utilized this imaging technique to investigate the kinetics of gastrointestinal recovery after radiatio…

Three-dimensional printed polymeric system to encapsulate human mesenchymal stem cells differentiated into islet-like insulin-producing aggregates for diabetes treatment Open

Omaima M. Sabek, Marco Farina, Daniel Fraga, Solmaz Afshar, Andrea Ballerini , et al. · 2016

Diabetes is one of the most prevalent, costly, and debilitating diseases in the world. Pancreas and islet transplants have shown success in re-establishing glucose control and reversing diabetic complications. However, both are limited by …

Mapping Radiation Injury and Recovery in Bone Marrow Using <sup>18</sup>F-FLT PET/CT and USPIO MRI in a Rat Model Open

David A. Rendon, Khushali Kotedia, Solmaz Afshar, Jyotinder N. Punia, Omaima M. Sabek , et al. · 2015

We demonstrated that (18)F-FLT PET/CT and USPIO MRI are valuable tools in mapping regional radiation exposure and the effects of radiation on BM. Analysis of the (18)F-FLT signal allowed for a clear demarcation of exposed BM regions and el…

Osteocalcin Effect on Human β-Cells Mass and Function Open

Omaima M. Sabek, Satoru K. Nishimoto, Daniel Fraga, Neelam Tejpal, Camillo Ricordi , et al. · 2015

The osteoblast-specific hormone osteocalcin (OC) was found to regulate glucose metabolism, fat mass, and β-cell proliferation in mice. Here, we investigate the effect of decarboxylated OC (D-OC) on human β-cell function and mass in culture…

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