Omaima Ali
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View article: Targeting JNK1/2 and P38 Mitogen‐Activated Protein Kinases With Pazopanib Mitigates Bleomycin‐Induced Lung Fibrosis
Targeting JNK1/2 and P38 Mitogen‐Activated Protein Kinases With Pazopanib Mitigates Bleomycin‐Induced Lung Fibrosis Open
Idiopathic pulmonary fibrosis is considered the most common type of interstitial lung disease. The principal aim of our research was to investigate the potential role of pazopanib treatment in alleviating bleomycin‐elicited pulmonary fibro…
View article: Diagnostic algorithm for clozapine-induced myocarditis: A systematic review
Diagnostic algorithm for clozapine-induced myocarditis: A systematic review Open
BACKGROUND Clozapine, the gold standard for resistant schizophrenia, is underused due to risks like clozapine-induced myocarditis (CIM). Non-specific biomarkers and inconsistent imaging, and the significant overlap with clozapine-induced p…
View article: Rhodococcus equi Endocarditis in Prosthetic Valve of a Heart Transplant Recipient
Rhodococcus equi Endocarditis in Prosthetic Valve of a Heart Transplant Recipient Open
View article: Tolerability and Adverse Effects in a Specialized Heart Failure Guideline‐Directed Medical Therapy Optimization Program
Tolerability and Adverse Effects in a Specialized Heart Failure Guideline‐Directed Medical Therapy Optimization Program Open
Background Utilization of heart failure (HF) guideline‐directed medical therapy (GDMT) to target doses is suboptimal, with studies citing adverse effects (AEs), physiological factors, and therapeutic inertia as potential contributing facto…
View article: Two versus three doses of COVID-19 vaccine and post-vaccination COVID-19 infection in hemodialysis patients
Two versus three doses of COVID-19 vaccine and post-vaccination COVID-19 infection in hemodialysis patients Open
A three dose regime of Sinopharm COVID-19 vaccine associated with significantly lower rate of reinfection COVID-19 infection in HD patients. Infected patients had significantly lower BMI, higher frequency of HCV and higher ferritin levels.
View article: Anti-C1q antibodies as a specific serological marker In patients with active lupus nephritis
Anti-C1q antibodies as a specific serological marker In patients with active lupus nephritis Open
Background: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, lupus nephritis (LN) is a widespread and serious complication and it is responsible for morbidity and mortality. This study aimed to detect the correlation be…
View article: Cognitive enhancing effects of pazopanib in D‑galactose/ovariectomized Alzheimer’s rat model: insights into the role of RIPK1/RIPK3/MLKL necroptosis signaling pathway
Cognitive enhancing effects of pazopanib in D‑galactose/ovariectomized Alzheimer’s rat model: insights into the role of RIPK1/RIPK3/MLKL necroptosis signaling pathway Open
Necroptosis, a programmed form of necrotic cell death carried out by receptor-interacting serine/threonine protein kinase 1 (RIPK1) and RIPK3, has been found to be implicated in the pathogenesis of Alzheimer’s disease (AD). An FDA-approved…
View article: Accuracy of Rapid Emergency Medicine Score and Sequential Organ Failure Assessment Score in predicting acute paraphenylenediamine poisoning adverse outcomes
Accuracy of Rapid Emergency Medicine Score and Sequential Organ Failure Assessment Score in predicting acute paraphenylenediamine poisoning adverse outcomes Open
View article: Evaluation of the Role of MRI in Differentiation Between Benign and Malignant Ovarian Tumors
Evaluation of the Role of MRI in Differentiation Between Benign and Malignant Ovarian Tumors Open
Magnetic Resonance Imaging became a significant method in the examination of women with adnexal masses.There is multiparametric assessment, using conventional sequences, post contrast assessment as well as the Diffusion MRI weighted imagin…
View article: Different Aspects of Diabetes in Hospitalized Patients with COVID-19
Different Aspects of Diabetes in Hospitalized Patients with COVID-19 Open
The prevalence of new-onset DM is significant among hospitalized COVID-19 patients. Older patients were more prone to disease severity with high mortality rate. Inflammatory markers such as CRP and ferritin were significantly related to th…
View article: Dual PI3K/Akt Inhibitors Bearing Coumarin-Thiazolidine Pharmacophores as Potential Apoptosis Inducers in MCF-7 Cells
Dual PI3K/Akt Inhibitors Bearing Coumarin-Thiazolidine Pharmacophores as Potential Apoptosis Inducers in MCF-7 Cells Open
Breast cancer is the most common malignancy worldwide; therefore, the development of new anticancer agents is essential for improved tumor control. By adopting the pharmacophore hybridization approach, two series of 7-hydroxyl-4-methylcoum…
View article: Pyrimidine-5-carbonitrile based potential anticancer agents as apoptosis inducers through PI3K/AKT axis inhibition in leukaemia K562
Pyrimidine-5-carbonitrile based potential anticancer agents as apoptosis inducers through PI3K/AKT axis inhibition in leukaemia K562 Open
A novel series of 4-(4-Methoxyphenyl)-2-(methylthio)pyrimidine-5-carbonitrile was developed linked to an aromatic moiety via N-containing bridge and then evaluated for their cytotoxic activity against MCF-7 and K562 cell lines. Seve…
View article: Prevalence and Risk Factors for Gestational Diabetes in Aswan, Egypt According to International Association of the Diabetes and Pregnancy Study Groups (IADPSG)
Prevalence and Risk Factors for Gestational Diabetes in Aswan, Egypt According to International Association of the Diabetes and Pregnancy Study Groups (IADPSG) Open
Background: The prevalence of diabetes in Egypt has significantly increased exceeding international rates.Egypt is now ranked ninth highest in the world in terms of the disease according to IDF, 2019.Objective: Estimation of the prevalence…
View article: Effect of sofosbuvir plus daclatasvir on virological response and liver function tests as a line of treatment for HCV related cirrhosis (a prospective cohort study)
Effect of sofosbuvir plus daclatasvir on virological response and liver function tests as a line of treatment for HCV related cirrhosis (a prospective cohort study) Open
View article: <p>Cardiovascular System Affection and Its Relation to First-Year Mortality in Patients Initiating Maintenance Hemodialysis</p>
Cardiovascular System Affection and Its Relation to First-Year Mortality in Patients Initiating Maintenance Hemodialysis Open
In conclusion, our study showed that the main risk factors for ESRD patients in Aswan University Hospital are hypertensive nephrosclerosis, diabetic nephropathy, glomerulonephritis and idiopathic etiology, and the main causes of first-year…
View article: Incidence of Acute Kidney Injury Among Cases with Suicidal Attempts of Paraphenylenediamine Poisoning in Aswan University Hospital
Incidence of Acute Kidney Injury Among Cases with Suicidal Attempts of Paraphenylenediamine Poisoning in Aswan University Hospital Open
Background: The rate of suicidal attempts with paraphenylenediamine (PPD) poisoning has raised steadily in the past few decades. Recently, a growing body of evidence demonstrated that PPD can lead to acute kidney injury (AKI). Objectives: …
View article: <p>Golgi Protein 73 versus Alpha-Fetoprotein as a New Biomarker in Early Diagnosis of Hepatocellular Carcinoma</p>
Golgi Protein 73 versus Alpha-Fetoprotein as a New Biomarker in Early Diagnosis of Hepatocellular Carcinoma Open
Golgi protein 73 is a promising and accurate biomarker for early detection of HCC.
View article: <p>The expression of microRNA 146a in patients with ischemic stroke: an observational study</p>
The expression of microRNA 146a in patients with ischemic stroke: an observational study Open
In conclusion, the expression of miRNA 146a is significantly downregulated in ischemic stroke patients. Further studies are needed to assess its diagnostic utility and therapeutic potentials.
View article: Epidemiology and risk factors of end stage renal disease in Aswan Governorate, Upper Egypt
Epidemiology and risk factors of end stage renal disease in Aswan Governorate, Upper Egypt Open
Background: End-stage renal disease (ESRD) has become a health issue worldwide.There is electronic data registry in developed countries, which allows for quick statistical analysis and assessment of the issue size for future planning.Objec…
View article: Serum vaspin: as a predictor of ischemic heart disease in Egyptian hemodialysis patients
Serum vaspin: as a predictor of ischemic heart disease in Egyptian hemodialysis patients Open
View article: miR‐26a Potentially Contributes to the Regulation of Fatty Acid and Sterol Metabolism In Vitro Human HepG2 Cell Model of Nonalcoholic Fatty Liver Disease
miR‐26a Potentially Contributes to the Regulation of Fatty Acid and Sterol Metabolism In Vitro Human HepG2 Cell Model of Nonalcoholic Fatty Liver Disease Open
Nonalcoholic fatty liver disease (NAFLD) is a metabolic‐related disorder ranging from steatosis to steatohepatitis, which may progress to cirrhosis and hepatocellular carcinoma (HCC). This study aimed at assessing the regulatory and protec…