Omair A. Shariq
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View article: Treatments for MEN1-associated endocrine tumours: three systematic reviews and a meta-analysis
Treatments for MEN1-associated endocrine tumours: three systematic reviews and a meta-analysis Open
None.
View article: A shot to the gut: appendicitis triggered by retained buckshot
A shot to the gut: appendicitis triggered by retained buckshot Open
Acute appendicitis is a common surgical emergency, most often caused by luminal obstruction from fecaliths. Rarely, foreign body ingestion can lead to appendicitis, particularly when small objects like lead shot become lodged in the append…
View article: Discordant risk factors between pancreatic neuroendocrine neoplasms and pancreatic ductal adenocarcinoma
Discordant risk factors between pancreatic neuroendocrine neoplasms and pancreatic ductal adenocarcinoma Open
Pancreatic neuroendocrine neoplasm (panNEN) is a rare malignancy and the second most common type of pancreatic cancer after pancreatic ductal adenocarcinoma (PDAC), but its etiology is poorly understood. We investigated whether the risk fa…
View article: Calcium sensing receptor expression is downregulated in gastroenteropancreatic neuroendocrine tumours via epigenetic mechanisms
Calcium sensing receptor expression is downregulated in gastroenteropancreatic neuroendocrine tumours via epigenetic mechanisms Open
Gastroenteropancreatic neuroendocrine tumours (GEP‐NETs), which may be hormone secreting (e.g., gastrinomas and insulinomas) or non‐secreting (also known as non‐functioning NETs) are associated with severe morbidity and have a median overa…
View article: 6808 Effect of Corticosteroid Premedication on Adrenal Vein Sampling in Patients with Primary Aldosteronism and Iodine Contrast Allergy
6808 Effect of Corticosteroid Premedication on Adrenal Vein Sampling in Patients with Primary Aldosteronism and Iodine Contrast Allergy Open
Disclosure: S. Mohan: None. O.A. Shariq: None. J.C. Andrews: None. W.F. Young: None. Background: Adrenal vein sampling (AVS) is performed in patients with primary aldosteronism (PA) to subtype surgically curable unilateral disease. During …
View article: SUN-343 Expression of Bromodomain and Extra-Terminal (BET) Proteins in Pancreatic Neuroendocrine Tumors and Mechanistic Implications of BET BD1- And BD2-Selective Inhibition
SUN-343 Expression of Bromodomain and Extra-Terminal (BET) Proteins in Pancreatic Neuroendocrine Tumors and Mechanistic Implications of BET BD1- And BD2-Selective Inhibition Open
O.A. Shariq: None. K.E. Lines: None. K.A. English: None. I. Rioja: Employee; Self; GlaxoSmithKline. A. Selberherr: None. H. Ferry: None. A.L. Oberg: None. R. Prinjha: Employee; Self; GlaxoSmithKline. D. Richards: None. R.V. Thakker: None. …
View article: Outpatient surgery benchmarks and practice variation patterns: case controlled study
Outpatient surgery benchmarks and practice variation patterns: case controlled study Open
Background: Despite numerous potential benefits of outpatient surgery, there is currently a lack of national benchmarking data available for hospitals and surgeons to compare their own outcomes as they transition toward outpatient surgery.…
View article: Contents
Contents Open
View article: OR16-03 Epigenetic Studies Of Pancreatic Neuroendocrine Tumours (PNETs) Reveal Decreased DNA Hydroxymethylation In Non-functioning PNETs But Not Insulinomas
OR16-03 Epigenetic Studies Of Pancreatic Neuroendocrine Tumours (PNETs) Reveal Decreased DNA Hydroxymethylation In Non-functioning PNETs But Not Insulinomas Open
Disclosure: K.A. English: None. A. Selberherr: None. O.A. Shariq: None. E. O'Neill: None. K.E. Lines: None. R.V. Thakker: None. Background: DNA methylation and hydroxymethylation (5hmC) are epigenetic alterations that can silence or mainta…
View article: SAT335 Bilateral Pheochromocytomas In Multiple Endocrine Neoplasia Type 2B: A Frozen Abdomen, A Slow Growing Mass, And A Backdoor Solution
SAT335 Bilateral Pheochromocytomas In Multiple Endocrine Neoplasia Type 2B: A Frozen Abdomen, A Slow Growing Mass, And A Backdoor Solution Open
Disclosure: O.A. Shariq: None. T.J. McKenzie: None. W.F. Young: None. Background: Multiple endocrine neoplasia type 2B (MEN2B) is most commonly caused by a germline methionine-to-threonine substitution at codon 918 (M918T) of the RET proto…
View article: Performance of General Surgical Procedures in Outpatient Settings Before and After Onset of the COVID-19 Pandemic
Performance of General Surgical Procedures in Outpatient Settings Before and After Onset of the COVID-19 Pandemic Open
Importance The American College of Surgeons (ACS) has advocated for the expansion of outpatient surgery to conserve limited hospital resources and bed capacity, while maintaining surgical throughput, during the COVID-19 pandemic. Objective…
View article: RF09 | PSAT94 Challenging the Status Quo: Are Routine Post-Operative Day 1 Non-Endocrine Labs Necessary After Adrenalectomy?
RF09 | PSAT94 Challenging the Status Quo: Are Routine Post-Operative Day 1 Non-Endocrine Labs Necessary After Adrenalectomy? Open
Background The Choosing Wisely campaign from the American Board of Internal Medicine (ABIM) Foundation has scrutinized the practice of routinely ordering tests that offer limited or no benefit to patients, and have the potential to cause h…
View article: miR-3156-5p is downregulated in serum of MEN1 patients and regulates expression of MORF4L2
miR-3156-5p is downregulated in serum of MEN1 patients and regulates expression of MORF4L2 Open
Multiple endocrine neoplasia type 1 (MEN1), caused by mutations in the MEN1 gene encoding menin, is an autosomal dominant disorder characterised by the combined occurrence of parathyroid, pituitary and pancreatic neuroendocrine tumours (NE…
View article: Clinical features and postoperative survival in patients with sporadic versus multiple endocrine neoplasia type 1-related pancreatic neuroendocrine tumors: An international cohort study
Clinical features and postoperative survival in patients with sporadic versus multiple endocrine neoplasia type 1-related pancreatic neuroendocrine tumors: An international cohort study Open
View article: Clinical Features, Genotype-Phenotype Correlations and Treatment Outcomes in Children and Adolescents with Multiple Endocrine Neoplasia Type 1: An International Cohort Study
Clinical Features, Genotype-Phenotype Correlations and Treatment Outcomes in Children and Adolescents with Multiple Endocrine Neoplasia Type 1: An International Cohort Study Open
Omair A. Shariq1,2, Kate E. Lines3, Katherine A. English3, Bahram Jafar-Mohammadi3, PhilippaPrentrice3, Ruth Casey5, Benjamin G. Challis5, Andreas Selberherr6, Fiona J. Ryan3, Ultan Healy3,Tom Kurzawinski7, Mehul T Dattani7, Irina Bancos8,…
View article: Hypoxia stimulates angiogenesis and a metabolic switch in human parathyroid adenoma cells
Hypoxia stimulates angiogenesis and a metabolic switch in human parathyroid adenoma cells Open
Hypoxia, a primary stimulus for angiogenesis, is important for tumour proliferation and survival. The effects of hypoxia on parathyroid tumour cells, which may also be important for parathyroid autotransplantation in patients, are, however…
View article: Adrenocortical carcinoma: current state of the art, ongoing controversies, and future directions in diagnosis and treatment
Adrenocortical carcinoma: current state of the art, ongoing controversies, and future directions in diagnosis and treatment Open
Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy with an annual incidence of ~1 case per million population. Differentiating between ACC and benign adrenocortical tumors can be challenging in patients who present with an inc…
View article: Surgical Aspects of Primary Hyperparathyroidism
Surgical Aspects of Primary Hyperparathyroidism Open
Parathyroidectomy (PTX) is the treatment of choice for symptomatic primary hyperparathyroidism (PHPT). It is also the treatment of choice in asymptomatic PHPT with evidence for target organ involvement. This review updates surgical aspects…
View article: Obesity-related hypertension: a review of pathophysiology, management, and the role of metabolic surgery
Obesity-related hypertension: a review of pathophysiology, management, and the role of metabolic surgery Open
Obesity is a significant public health challenge worldwide and is inextricably linked to adverse cardiovascular outcomes. The relationship between excess adiposity and increased blood pressure is well established, and it is estimated that …
View article: Epigenetic Dysregulation in Pituitary Tumors
Epigenetic Dysregulation in Pituitary Tumors Open
Pituitary tumors are common intracranial neoplasms associated with significant morbidity due to hormonal dysregulation and neurologic symptoms. Somatic mutations are uncommon in sporadic pituitary adenomas, and only few monogenic condition…