Ómar A. Saldarriaga
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View article: Exploring the liver microenvironment following successful therapy for HCV: gene expression profiling and residual T cell infiltration
Exploring the liver microenvironment following successful therapy for HCV: gene expression profiling and residual T cell infiltration Open
Background & aims Direct-acting antivirals (DAAs) revolutionized hepatitis C (HCV) treatment. Yet, some patients present with persistent inflammation and still face adverse outcomes, including cirrhosis and hepatocellular carcinoma, de…
View article: Alterations in the hepatic microenvironment following direct-acting antiviral therapy for chronic hepatitis C
Alterations in the hepatic microenvironment following direct-acting antiviral therapy for chronic hepatitis C Open
Background and aims. The first direct-acting antivirals (DAAs) to treat the viral hepatitis C (HCV) became available in 2011. Despite numerous clinical studies of patient outcomes after treatment, few have evaluated changes in the liver mi…
View article: Hepatic and pulmonary macrophage activity in a mucosal challenge model of Ebola virus disease
Hepatic and pulmonary macrophage activity in a mucosal challenge model of Ebola virus disease Open
Background The inflammatory macrophage response contributes to severe Ebola virus disease, with liver and lung injury in humans. Objective We sought to further define the activation status of hepatic and pulmonary macrophage populations in…
View article: Disparate outcomes in Hispanic patients with metabolic dysfunction-associated steatotic liver disease/steatohepatitis and type 2 diabetes: Large cohort study
Disparate outcomes in Hispanic patients with metabolic dysfunction-associated steatotic liver disease/steatohepatitis and type 2 diabetes: Large cohort study Open
BACKGROUND Metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) are a growing health burden across a significant portion of the global patient population. However, the…
View article: Heterogeneity in intrahepatic macrophage populations and druggable target expression in patients with steatotic liver disease-related fibrosis
Heterogeneity in intrahepatic macrophage populations and druggable target expression in patients with steatotic liver disease-related fibrosis Open
Appreciating individual differences within the hepatic microenvironment of patients with SLD may be paramount to developing effective treatments. These results may explain why such a small percentage of patients have responded to macrophag…
View article: Cellular and Molecular Mechanisms of Liver Fibrosis in Patients with NAFLD
Cellular and Molecular Mechanisms of Liver Fibrosis in Patients with NAFLD Open
The expression of immune- and cancer-related genes was measured in liver biopsies from 107 NAFLD patients. The strongest difference in overall gene expression was between liver fibrosis stages F3 and F4, with 162 cirrhosis-associated genes…
View article: 258 Analysis of the Hepatic Microenvironment Before and After Direct-Acting Antiviral (DAA) Therapy for Viral Hepatitis C
258 Analysis of the Hepatic Microenvironment Before and After Direct-Acting Antiviral (DAA) Therapy for Viral Hepatitis C Open
OBJECTIVES/GOALS: The effect of the Direct-Acting Antiviral (DAA) on hepatic histopathological features from patients treated for HCV has not been thoroughly evaluated. The goals of this retrospective study were to determines differences b…
View article: 373 Identification of potential targets for immunotherapy in a cynomolgus macaque model of Ebola virus disease
373 Identification of potential targets for immunotherapy in a cynomolgus macaque model of Ebola virus disease Open
OBJECTIVES/GOALS: Ebola virus infection causes severe disease and liver injury in humans. Macrophages contribute to inflammatory signaling and are prevalent in the liver. We assessed the activation status, including therapeutic target expr…
View article: Patients with fibrosis from non-alcoholic steatohepatitis have heterogeneous intrahepatic macrophages and therapeutic targets
Patients with fibrosis from non-alcoholic steatohepatitis have heterogeneous intrahepatic macrophages and therapeutic targets Open
Background and Aims In clinical trials for reducing fibrosis in NASH patients, therapeutics that target macrophages have had variable results. We evaluated intrahepatic macrophages in patients with non-alcoholic steatohepatitis to determin…
View article: Spatial molecular and cellular determinants of STAT3 activation in liver fibrosis progression in non-alcoholic fatty liver disease
Spatial molecular and cellular determinants of STAT3 activation in liver fibrosis progression in non-alcoholic fatty liver disease Open
Advanced liver fibrosis is the main determinant of mortality in patients with NASH. This study showed using liver biopsies from 133 patients with NAFLD, that STAT3 activation in non-hepatocyte areas is strongly associated with fibrosis sev…
View article: Macrophage infection, activation, and histopathological findings in ebolavirus infection
Macrophage infection, activation, and histopathological findings in ebolavirus infection Open
Macrophages contribute to Ebola virus disease through their susceptibility to direct infection, their multi-faceted response to ebolaviruses, and their association with pathological findings in tissues throughout the body. Viral attachment…
View article: Pathologic Inflammation in Malnutrition Is Driven by Proinflammatory Intestinal Microbiota, Large Intestine Barrier Dysfunction, and Translocation of Bacterial Lipopolysaccharide
Pathologic Inflammation in Malnutrition Is Driven by Proinflammatory Intestinal Microbiota, Large Intestine Barrier Dysfunction, and Translocation of Bacterial Lipopolysaccharide Open
Acute malnutrition, or wasting, is implicated in over half of all deaths in children under five and increases risk of infectious disease. Studies in humans and preclinical models have demonstrated that malnutrition is linked to an immature…
View article: Cutting-Edge Platforms for Analysis of Immune Cells in the Hepatic Microenvironment—Focus on Tumor-Associated Macrophages in Hepatocellular Carcinoma
Cutting-Edge Platforms for Analysis of Immune Cells in the Hepatic Microenvironment—Focus on Tumor-Associated Macrophages in Hepatocellular Carcinoma Open
The role of tumor-associated macrophages (TAMs) in the pathogenesis of hepatocellular carcinoma (HCC) is poorly understood. Most studies rely on platforms that remove intrahepatic macrophages from the microenvironment prior to evaluation. …
View article: Post-treatment bacterial endocarditis mimicking fungal organisms: a morphologic comparison and tips for avoiding this diagnostic pitfall
Post-treatment bacterial endocarditis mimicking fungal organisms: a morphologic comparison and tips for avoiding this diagnostic pitfall Open
Antibiotic therapy for bacterial endocarditis can alter the inflammatory reaction to infection, bacterial size, septa formation, and staining characteristics. Knowledge of these therapy-related effects and use of high-power magnification h…
View article: Comparison of liver biopsies before and after direct-acting antiviral therapy for hepatitis C and correlation with clinical outcome
Comparison of liver biopsies before and after direct-acting antiviral therapy for hepatitis C and correlation with clinical outcome Open
View article: Environmental, Metabolic, and Inflammatory Factors Converge in the Pathogenesis of Moderate Acute Malnutrition in Children: An Observational Cohort Study
Environmental, Metabolic, and Inflammatory Factors Converge in the Pathogenesis of Moderate Acute Malnutrition in Children: An Observational Cohort Study Open
Acute malnutrition affects more than 50 million children worldwide. These children are at an increased risk of morbidity and mortality from infectious disease. However, the pathogenesis of acute malnutrition and mechanisms underlying the i…
View article: Patients with advanced hepatic fibrosis before or after direct-acting antiviral therapy for chronic hepatitis C are at risk for development of liver cancer
Patients with advanced hepatic fibrosis before or after direct-acting antiviral therapy for chronic hepatitis C are at risk for development of liver cancer Open
Direct-acting antivirals (DAA) have replaced interferon (IFN)-based therapies for hepatitis C virus. This study examined differences in histopathologic features in paired liver biopsies collected before and after DAA and evaluated clinical…
View article: Endoderm and Hepatic Progenitor Cells Engraft in the Quiescent Liver Concurrent with Intrinsically Activated Epithelial-to-Mesenchymal Transition
Endoderm and Hepatic Progenitor Cells Engraft in the Quiescent Liver Concurrent with Intrinsically Activated Epithelial-to-Mesenchymal Transition Open
Stem cell transplantation to the liver is a promising therapeutic strategy for a variety of disorders. Hepatocyte transplantation has short-term efficacy but can be problematic due to portal hypertension, inflammation, and sinusoidal throm…
View article: Multispectral Imaging Enables Characterization of Intrahepatic Macrophages in Patients With Chronic Liver Disease
Multispectral Imaging Enables Characterization of Intrahepatic Macrophages in Patients With Chronic Liver Disease Open
Intrahepatic macrophages influence the composition of the microenvironment, host immune response to liver injury, and development of fibrosis. Compared with stellate cells, the role of macrophages in the development of fibrosis remains unc…
View article: Multispectral Imaging Differentiates Unique Macrophage Profiles in Patients with Distinct Chronic Liver Diseases
Multispectral Imaging Differentiates Unique Macrophage Profiles in Patients with Distinct Chronic Liver Diseases Open
Intrahepatic macrophages influence the composition of the microenvironment, host immune response to liver injury, and development of fibrosis. Compared to stellate cells, the role of intrahepatic macrophages in the development of fibrosis …
View article: Direct‐Acting Antiviral Treatment of Patients with Hepatitis C Resolves Serologic and Histopathologic Features of Autoimmune Hepatitis
Direct‐Acting Antiviral Treatment of Patients with Hepatitis C Resolves Serologic and Histopathologic Features of Autoimmune Hepatitis Open
Patients with hepatitis C virus (HCV) often have elevated serum markers and histologic features of autoimmune hepatitis (AIH). We evaluated an HCV‐positive (HCV+) study group that had elevated serum markers of AIH before starting direct‐ac…
View article: Fibrogenic Gene Expression in Hepatic Stellate Cells Induced by HCV and HIV Replication in a Three Cell Co-Culture Model System
Fibrogenic Gene Expression in Hepatic Stellate Cells Induced by HCV and HIV Replication in a Three Cell Co-Culture Model System Open
Retrospective studies indicate that co-infection of hepatitis C virus (HCV) and human immunodeficiency virus (HIV) accelerates hepatic fibrosis progression. We have developed a co-culture system (MLH) comprising primary m acrophages, hepat…
View article: Transcriptional Profiling in Experimental Visceral Leishmaniasis Reveals a Broad Splenic Inflammatory Environment that Conditions Macrophages toward a Disease-Promoting Phenotype
Transcriptional Profiling in Experimental Visceral Leishmaniasis Reveals a Broad Splenic Inflammatory Environment that Conditions Macrophages toward a Disease-Promoting Phenotype Open
Visceral Leishmaniasis (VL), caused by the intracellular protozoan Leishmania donovani, is characterized by relentlessly increasing visceral parasite replication, cachexia, massive splenomegaly, pancytopenia and ultimately death. Progressi…
View article: Splenic CD4+ T Cells in Progressive Visceral Leishmaniasis Show a Mixed Effector-Regulatory Phenotype and Impair Macrophage Effector Function through Inhibitory Receptor Expression
Splenic CD4+ T Cells in Progressive Visceral Leishmaniasis Show a Mixed Effector-Regulatory Phenotype and Impair Macrophage Effector Function through Inhibitory Receptor Expression Open
Visceral leishmaniasis (VL), caused by infection with the intracellular protozoan Leishmania donovani, is a chronic progressive disease with a relentlessly increasing parasite burden in the spleen, liver and bone marrow. The disease is cha…
View article: Polymorphism in 1908STR1934 locus of the 3' UTR of the Nramp1 bovine gene in eight cattle breeds
Polymorphism in 1908STR1934 locus of the 3' UTR of the Nramp1 bovine gene in eight cattle breeds Open
Summary The Nramp1 gene has been associated with natural resistance to intracellular microorganisms in several species including bovine. Recent evidence suggests an association between polymorphism in the 3´ untranslated region (3´ UTR) of…
View article: Ganado Blanco Orejinegro (BON): Una alternativa para la producción en Colombia
Ganado Blanco Orejinegro (BON): Una alternativa para la producción en Colombia Open
Resumen El ganado Blanco Orejinegro descendiente del ganado traído por Colón durante su segundo viaje, ha sobrevivido durante casi 500 años en las áreas tropicales colombianas productoras de café. Además de su capacidad adaptativa este gan…
View article: Inmunobiología de la infección por Brucella spp: Fundamentos para una estrategia vacunal
Inmunobiología de la infección por Brucella spp: Fundamentos para una estrategia vacunal Open
Resumen Las especies de Brucella causan enfermedades en animales domésticos y salvajes incluyendo bovinos, ovinos, caprinos, suinos, caninos. Esta bacteria representa un serio problema económico para la ganadería mundial; en Colombia por e…
View article: Genes y plásmidos de la Salmonella spp. asociados con virulencia
Genes y plásmidos de la Salmonella spp. asociados con virulencia Open
Resumen Las serovariedades de Salmonella, patógenos intracelulares gram negativos, afectan varias especies animales como las aves, los cerdos, los bovinos y el hombre. Después de la ingestión de alimentos o aguas contaminadas, la bacteria …
View article: Respuesta inmune y estrategias de evasión durante la infección con Brucella spp.
Respuesta inmune y estrategias de evasión durante la infección con Brucella spp. Open
Resumen La Brucella es una bacteria Gram-negativa, intracelular facultativa que infecta en forma persistente a humanos y animales domésticos y salvajes. Este género de bacterias se replica en los fagocitos mononucleares del hospedero, evad…
View article: Estandarización de la técnica ELISA en leche entera para la detección de anticuerpos contra el Herpesvirus bovino-1 (HVB-1)
Estandarización de la técnica ELISA en leche entera para la detección de anticuerpos contra el Herpesvirus bovino-1 (HVB-1) Open
Resumen Con el propósito de ampliar la aplicabilidad de la técnica ELISA para el control de las enfermedades infecciosas, en el contexto de la ganadería nacional y específicamente para contribuir al conocimiento y al control de la Rinotraq…