Aly M. Abdelrahman
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View article: Prevalence of HIV among Patients Attending Endoscopy Units in Sharqia Government Hospitals: Retrospective Study
Prevalence of HIV among Patients Attending Endoscopy Units in Sharqia Government Hospitals: Retrospective Study Open
View article: Riociguat Alleviates Cisplatin-Caused Kidney Injury by Suppressing Oxidative Stress and Inflammation
Riociguat Alleviates Cisplatin-Caused Kidney Injury by Suppressing Oxidative Stress and Inflammation Open
Background: Cisplatin (CP), a platinum-based chemotherapeutic agent, is widely used to treat cancer but causes nephrotoxicity. Riociguat, a soluble guanylate cyclase (sGC) stimulator that enhances the nitric oxide–sGC–cGMP signaling pathwa…
View article: Effect of Riociguat on Adenine-Induced Chronic Kidney Disease in Rats
Effect of Riociguat on Adenine-Induced Chronic Kidney Disease in Rats Open
Riociguat is a soluble guanylate cyclase (sGC) activator that increases the levels of cyclic guanosine monophosphate (cGMP). cGMP is known to play a key role in regulating kidney function. This research sought to investigate the possible p…
View article: Utilization patterns of drugs used in the treatment of chronic obstructive pulmonary disease in a tertiary hospital
Utilization patterns of drugs used in the treatment of chronic obstructive pulmonary disease in a tertiary hospital Open
Background: Chronic obstructive pulmonary disease (COPD) is a disease where there is a limitation of airflow that comes in and out of the lungs due to some abnormalities of the lung`s airway. COPD affects 10% of the global population and i…
View article: Glucagon-like Peptide-1 Receptor Agonists and Diabetic Kidney Disease: From Bench to Bed-Side
Glucagon-like Peptide-1 Receptor Agonists and Diabetic Kidney Disease: From Bench to Bed-Side Open
Glucagon-like peptide-1 (GLP-1) receptor agonists are currently available for the management of type 2 diabetes mellitus. They have been shown to help with diabetic kidney diseases through multiple mechanisms. In this review, we will shed …
View article: Glucagon Like Peptide-1 Receptor Agonists and Diabetic Kidney Disease: From Bench to Bed-Side
Glucagon Like Peptide-1 Receptor Agonists and Diabetic Kidney Disease: From Bench to Bed-Side Open
Glucagon like peptide-1 (GLP-1) receptor agonists are currently available for the management of type 2 diabetes mellitus. They have been shown to help with diabetic kidney diseases through multiple mechanisms. In this review, we will shed …
View article: Nephroprotective effects of the soluble guanylyl cyclase stimulator, riociguat in doxorubicin-induced acute kidney injury in rats
Nephroprotective effects of the soluble guanylyl cyclase stimulator, riociguat in doxorubicin-induced acute kidney injury in rats Open
View article: Evaluation of hyperkalemia associated with intravenous co-trimoxazole in hospitalized patients in Oman
Evaluation of hyperkalemia associated with intravenous co-trimoxazole in hospitalized patients in Oman Open
View article: Sodium-Glucose Co-Transporter 2 Inhibitors: Mechanism of Action and Efficacy in Non-Diabetic Kidney Disease from Bench to Bed-Side
Sodium-Glucose Co-Transporter 2 Inhibitors: Mechanism of Action and Efficacy in Non-Diabetic Kidney Disease from Bench to Bed-Side Open
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are currently available for the management of type 2 diabetes mellitus. SGLT2i acts by inhibiting renal SGLT2, thereby increasing glucosuria and lowering serum glucose. Recent trials are e…
View article: Sodium Glucose Co-transporter 2 Inhibitors: Pharmacology, Mechanism of Action and Efficacy in Non-diabetic Kidney Disease from Bench to Bed-Side
Sodium Glucose Co-transporter 2 Inhibitors: Pharmacology, Mechanism of Action and Efficacy in Non-diabetic Kidney Disease from Bench to Bed-Side Open
Sodium glucose cotransporter 2 inhibitors (SGLT2i) are currently available for the management of type 2 diabetes mellitus. SGLT2i act by inhibiting renal SGLT2, thereby increasing glucosuria and lowering serum glucose. Recent trials are em…
View article: Nephroprotective effects of diminazene on doxorubicin-induced acute kidney injury in rats
Nephroprotective effects of diminazene on doxorubicin-induced acute kidney injury in rats Open
This study aimed to investigate the potential protective effects of diminazene, an activator of angiotensin II converting enzyme (ACE2), on kidney function and structure in rats with acute kidney injury (AKI) induced by the anticancer drug…
View article: Overview of the use of antiarrhythmic drugs at a tertiary hospital in Oman
Overview of the use of antiarrhythmic drugs at a tertiary hospital in Oman Open
Background: Antiarrhythmic drugs are commonly used to treat arrhythmia. However, data on the usage pattern of antiarrhythmic drugs, associated side effects, and the role of clinical pharmacist interventions in the Middle East are scarce. O…
View article: Potentially Harmful Drug–Drug Interactions and Their Associated Factors Among Hospitalized Cardiac Patients: A Cross-Sectional Study
Potentially Harmful Drug–Drug Interactions and Their Associated Factors Among Hospitalized Cardiac Patients: A Cross-Sectional Study Open
Potential drug-drug interactions were highly prevalent among hospitalized cardiac patients at Sultan Qaboos University Hospital, Muscat, Oman. Patients having diabetes as a comorbidity and with a high number of administered drugs were at a…
View article: Access- and non-access-related infections among patients receiving haemodialysis: Experience of an academic centre in Oman
Access- and non-access-related infections among patients receiving haemodialysis: Experience of an academic centre in Oman Open
Infections in patients undergoing haemodialysis are common and are dominated by non-access-related infections. Pneumonia was found to be the most prevalent infection in this population. Gram-negative bacteria, predominantly K. pneumonia…
View article: Antibiotics utilization patterns and dosage appropriateness among patients receiving hemodialysis
Antibiotics utilization patterns and dosage appropriateness among patients receiving hemodialysis Open
View article: Utilization patterns of antihypertensive drugs in the management of hypertension among patients with chronic kidney disease at a tertiary hospital
Utilization patterns of antihypertensive drugs in the management of hypertension among patients with chronic kidney disease at a tertiary hospital Open
Background: Objective of the current investigation was to identify the utilization patterns of antihypertensive drugs among hypertensive patients with chronic kidney disease at Sultan Qaboos university hospital.Methods: This is a retrospec…
View article: Effect of concomitant treatment of curcumin and melatonin on cisplatin-induced nephrotoxicity in rats
Effect of concomitant treatment of curcumin and melatonin on cisplatin-induced nephrotoxicity in rats Open
Cisplatin (CP) is a potent anticancer drug used to treat solid tumors. Its use, however, is dose-limited by its nephrotoxicity. We aimed to compare the effect of melatonin and curcumin given singly, with that of a combination of these two …
View article: Aortae of Young Rats with Metabolic Syndrome Exhibit Enhanced Vasoconstrictor Activity Than Older Rats
Aortae of Young Rats with Metabolic Syndrome Exhibit Enhanced Vasoconstrictor Activity Than Older Rats Open
Background Metabolic syndrome (MetS) causes pathological remodeling of the heart and adjacent vessels. The functional changes in the big vessels in different age groups had not been fully delineated. Aim of the work The present study was p…
View article: Study of immediate changes in blood coagulation in an experimental model of ischemia/reperfusion injury of the kidney
Study of immediate changes in blood coagulation in an experimental model of ischemia/reperfusion injury of the kidney Open
Introduction Ischemia- reperfusion injury (IRI) in the kidney triggers multifaceted network of plasma cascades including the complement, coagulation, kinins, and fibrinolytic system, which play major role in the reperfusion-triggered infla…
View article: Effects of the SGLT-2 Inhibitor Canagliflozin on Adenine-Induced Chronic Kidney Disease in Rats
Effects of the SGLT-2 Inhibitor Canagliflozin on Adenine-Induced Chronic Kidney Disease in Rats Open
Canagliflozin ameliorated adenine - induced CKD in rats, through reduction of several inflammatory and oxidative stress parameters, and other indices such as uremic toxins, and by antagonizing the increase in the renal content of the trans…
View article: Effect of levosimendan, a calcium sensitizer, on cisplatin-induced nephrotoxicity in rats
Effect of levosimendan, a calcium sensitizer, on cisplatin-induced nephrotoxicity in rats Open
We investigated the effect of levosimendan on cisplatin (Cis)-induced nephrotoxicity. Rats were divided into four groups (n = 6). The first and second groups received normal saline (control) and intraperitoneal (i.p.) cisplatin (6 mg/kg) o…
View article: The renoprotective effect of the dipeptidyl peptidase-4 inhibitor sitagliptin on adenine-induced kidney disease in rats
The renoprotective effect of the dipeptidyl peptidase-4 inhibitor sitagliptin on adenine-induced kidney disease in rats Open
View article: Role of Ketotifen in Methotrexate-induced Nephrotoxicity in Rats
Role of Ketotifen in Methotrexate-induced Nephrotoxicity in Rats Open
View article: Possible Protective Effect of Diacerein on Doxorubicin-Induced Nephrotoxicity in Rats
Possible Protective Effect of Diacerein on Doxorubicin-Induced Nephrotoxicity in Rats Open
Nephrotoxicity is one of the limiting factors for using doxorubicin (DOX). Interleukin 1 has major role in DOX-induced nephrotoxicity, so we investigated the effect of interleukin 1 receptor antagonist diacerein (DIA) on DOX-induced nephro…
View article: Effect of Metformin and Sitagliptin on Doxorubicin-Induced Cardiotoxicity in Rats: Impact of Oxidative Stress, Inflammation, and Apoptosis
Effect of Metformin and Sitagliptin on Doxorubicin-Induced Cardiotoxicity in Rats: Impact of Oxidative Stress, Inflammation, and Apoptosis Open
Doxorubicin (DOX) is a widely used antineoplastic drug whose efficacy is limited by its cardiotoxicity. The aim of this study was to investigate the possible protective role of the antidiabetic drugs metformin (250 mg/kg dissolved in DW p.…