Omar Mourad
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View article: Impact of type 2 diabetes mellitus on interstitial lung disease risk in rheumatoid arthritis
Impact of type 2 diabetes mellitus on interstitial lung disease risk in rheumatoid arthritis Open
BACKGROUND This study investigates the impact of type 2 diabetes mellitus (T2DM) on the risk of interstitial lung disease (ILD) and its subtypes in patients with rheumatoid arthritis (RA). RA is often complicated by ILD. T2DM has systemic …
View article: Growth Factor-Based Manufacturing of Human Pluripotent Stem Cell-Derived Cardiomyocytes Using the Vertical Wheel Bioreactor System
Growth Factor-Based Manufacturing of Human Pluripotent Stem Cell-Derived Cardiomyocytes Using the Vertical Wheel Bioreactor System Open
Background Multiple protocols have been reported for the large-scale generation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) in bioreactors using small molecules; however, no comparable bioreactor-based methods have bee…
View article: Human pluripotent stem cell-derived atrioventricular node-like pacemaker cells exhibit biological conduction bridge properties in vitro and in vivo
Human pluripotent stem cell-derived atrioventricular node-like pacemaker cells exhibit biological conduction bridge properties in vitro and in vivo Open
Summary The atrioventricular node (AVN) ensures synchronized heart contractions by establishing the electrical connection between the atria and ventricles. Dysfunction of the pacemaker cells of the AVN leads to atrioventricular block (AV b…
View article: Single cell transcriptomic analysis of SGLT2 expression supports an indirect or off-target role for the cardioprotective benefits of empagliflozin in heart failure
Single cell transcriptomic analysis of SGLT2 expression supports an indirect or off-target role for the cardioprotective benefits of empagliflozin in heart failure Open
View article: Microvessel co-transplantation improves poor remuscularization by hiPSC-cardiomyocytes in a complex disease model of myocardial infarction and type 2 diabetes
Microvessel co-transplantation improves poor remuscularization by hiPSC-cardiomyocytes in a complex disease model of myocardial infarction and type 2 diabetes Open
View article: BISAP beyond pancreatitis: a new horizon in acute kidney injury prediction
BISAP beyond pancreatitis: a new horizon in acute kidney injury prediction Open
Background: Acute kidney injury (AKI) is a common complication in acute pancreatitis (AP), with a significant impact on mortality. The Bedside Index for Severity in Acute Pancreatitis (BISAP) score is well-established for assessing mortali…
View article: Systemic sclerosis and acute heart failure in prosthetic heart valve patients: A retrospective analysis
Systemic sclerosis and acute heart failure in prosthetic heart valve patients: A retrospective analysis Open
Background: Acute heart failure in patients with prosthetic heart valves is a complex problem with clinical and therapeutic challenges. Systemic sclerosis is a chronic autoimmune disease frequently associated with valvular abnormalities. T…
View article: Outpatient insulin use in type 2 diabetes mellitus and acute respiratory distress syndrome outcomes: A retrospective cohort study
Outpatient insulin use in type 2 diabetes mellitus and acute respiratory distress syndrome outcomes: A retrospective cohort study Open
BACKGROUND The impact of type 2 diabetes mellitus (T2DM) on acute respiratory distress syndrome (ARDS) is debatable. T2DM was suspected to reduce the risk and complications of ARDS. However, during coronavirus disease 2019 (COVID-19), T2DM…
View article: Automatic implantable cardioverter defibrillator (AICD) implantation as secondary prevention of cardiac sarcoidosis-associated ventricular tachycardia
Automatic implantable cardioverter defibrillator (AICD) implantation as secondary prevention of cardiac sarcoidosis-associated ventricular tachycardia Open
Background: Cardiac sarcoidosis can cause a wide range of symptoms, including shortness of breath, chest pain, oedema, and fatal arrhythmias such as ventricular tachycardia (VT). Because the symptoms can be nonspecific, diagnosing cardiac …
View article: Treatment of Gout in Patients with CrCl ≤30 mL/min and/or on Hemodialysis: A Review
Treatment of Gout in Patients with CrCl ≤30 mL/min and/or on Hemodialysis: A Review Open
Gout is highly prevalent in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD), owing to impaired uric acid excretion. However, treating gout in this population is challenging due to concerns about medication saf…
View article: GLP-1 receptor agonists: A novel pharmacotherapy for binge eating (Binge eating disorder and bulimia nervosa)? A systematic review
GLP-1 receptor agonists: A novel pharmacotherapy for binge eating (Binge eating disorder and bulimia nervosa)? A systematic review Open
Early findings suggest promising effects of GLP-1RAs on BEB. However, rigorous clinical trials are needed to firmly establish efficacy, dosing, safety, and comparative effectiveness before considering GLP-1RAs a viable novel approach.
View article: Single Cell Transcriptomic Analysis of SGLT2 Expression Supports an Indirect Role for the Cardioprotective Benefits of Empagliflozin in Heart Failure
Single Cell Transcriptomic Analysis of SGLT2 Expression Supports an Indirect Role for the Cardioprotective Benefits of Empagliflozin in Heart Failure Open
View article: CARDIOVASCULAR OUTCOMES IN SYSTEMIC SCLEROSIS-INDUCED PULMONARY HYPERTENSION
CARDIOVASCULAR OUTCOMES IN SYSTEMIC SCLEROSIS-INDUCED PULMONARY HYPERTENSION Open
View article: SGLT2 transcriptomic expression atlas supports a kidney-centric role for empagliflozin’s benefits in heart failure
SGLT2 transcriptomic expression atlas supports a kidney-centric role for empagliflozin’s benefits in heart failure Open
Sodium-glucose cotransporter 2 inhibitors (SGLT2i), such as empagliflozin, have shown remarkable benefits in reducing cardiovascular events and mortality in patients with heart failure (HF) irrespective of diabetic status. Because of the m…
View article: Antisenescence Therapy Improves Function in a Human Model of Cardiac Fibrosis-on-a-Chip
Antisenescence Therapy Improves Function in a Human Model of Cardiac Fibrosis-on-a-Chip Open
Cardiac fibrosis is a significant contributor to heart failure and is characterized by abnormal ECM deposition and impaired contractile function. We have previously developed a model of cardiac fibrosis via TGF-β treatment of engineered mi…
View article: Perception of Biostatistics by Lebanese Medical Students: A Cross-Sectional Study
Perception of Biostatistics by Lebanese Medical Students: A Cross-Sectional Study Open
Background Inadequate use of statistics in biomedical research might not only affect science but also harm human beings if applied in medical practice. Biostatistics is fundamental to improve understanding and appraising of evidence-based …