Omar K. Sial
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View article: Sex-Specific Regulation of Stress Susceptibility by the Astrocytic Gene<i>Htra1</i>
Sex-Specific Regulation of Stress Susceptibility by the Astrocytic Gene<i>Htra1</i> Open
Major depressive disorder (MDD) is linked to impaired structural and synaptic plasticity in limbic brain regions. Astrocytes, which regulate synapses and are influenced by chronic stress, likely contribute to these changes. We analyzed ast…
View article: RGS4 Actions in Mouse Prefrontal Cortex Modulate Behavioral and Transcriptomic Responses to Chronic Stress and Ketamine
RGS4 Actions in Mouse Prefrontal Cortex Modulate Behavioral and Transcriptomic Responses to Chronic Stress and Ketamine Open
View article: Alprazolam exposure during adolescence induces long-lasting dysregulation in reward sensitivity to morphine and second messenger signaling in the VTA-NAc pathway
Alprazolam exposure during adolescence induces long-lasting dysregulation in reward sensitivity to morphine and second messenger signaling in the VTA-NAc pathway Open
Increased use of benzodiazepines in adolescents have been reported, with alprazolam (ALP) being the most abused. Drug abuse during adolescence can induce changes with lasting consequences. This study investigated the neurobiological conseq…
View article: Ptchd1 mediates opioid tolerance via cholesterol-dependent effects on μ-opioid receptor trafficking
Ptchd1 mediates opioid tolerance via cholesterol-dependent effects on μ-opioid receptor trafficking Open
View article: Social Buffering is Dependent on Mutual Experience in Adolescent Male Mice Exposed to Social Defeat Stress
Social Buffering is Dependent on Mutual Experience in Adolescent Male Mice Exposed to Social Defeat Stress Open
Background Individuals who experience emotional, physical, or sexual abuse as children suffer from higher rates of major depressive disorder, drug abuse, and suicide. Early life interventions such as peer support groups can be beneficial t…
View article: Exposure to Vicarious Social Defeat Stress and Western-Style Diets During Adolescence Leads to Physiological Dysregulation, Decreases in Reward Sensitivity, and Reduced Antidepressant Efficacy in Adulthood
Exposure to Vicarious Social Defeat Stress and Western-Style Diets During Adolescence Leads to Physiological Dysregulation, Decreases in Reward Sensitivity, and Reduced Antidepressant Efficacy in Adulthood Open
A dramatic increase in the prevalence of major depression and diet-related disorders in adolescents has been observed over several decades, yet the mechanisms underlying this comorbidity have only recently begun to be elucidated. Exposure …
View article: The Resilient Phenotype Induced by Prophylactic Ketamine Exposure During Adolescence Is Mediated by the Ventral Tegmental Area–Nucleus Accumbens Pathway
The Resilient Phenotype Induced by Prophylactic Ketamine Exposure During Adolescence Is Mediated by the Ventral Tegmental Area–Nucleus Accumbens Pathway Open
View article: Nicotine treatment buffers negative behavioral consequences induced by exposure to physical and emotional stress in adolescent male mice
Nicotine treatment buffers negative behavioral consequences induced by exposure to physical and emotional stress in adolescent male mice Open
View article: Ketamine: The final frontier or another depressing end?
Ketamine: The final frontier or another depressing end? Open