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View article: Supplementary Figure S2 from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895
Supplementary Figure S2 from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895 Open
Inhibition of OATP1B1 and OATP1B3 by TL-895. Inhibition of EβG transport by OATP1B1 (A) and CCK-8 transport by OATP1B3 (B) in the presence and absence of Varying concentrations of TL-895 in engineered HEK293 cells. Data represent mean valu…
View article: Supplementary Figure S4 from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895
Supplementary Figure S4 from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895 Open
Assessment of DDI liabilities induced by TL-895. Influence of TL-895 (3 mg/kg) on circulating concentrations of CDCA-24G (A), oral (20 mg/kg) pravastatin (B), or oral (30 mg/kg) gilteritinib in C57BL/6 mice (C) and NSG mice (D). Data repre…
View article: Table 1 from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895
Table 1 from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895 Open
Dependence of TL-895 pharmacokinetics on mouse strain, CYP3A genotype, TL-895 dose, and sex
View article: Figure 3 from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895
Figure 3 from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895 Open
Interaction of TL-895 with CYP3A4 and CYP3A4-mediated metabolism. Metabolism of TL-895 by CYP3A4 microsomes (A) and the influence of CYP3A deficiency [CYP(−/−)] on the circulating concentration of oral (3 mg/kg) TL-895 in mice (B; N = 5 pe…
View article: Supplementary Figure S5 from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895
Supplementary Figure S5 from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895 Open
Activity of TL-895 on LYN kinase. KINOMEscan activity of TL-895 and nilotinib, a positive control, against LYN kinase, a post-translational regulator of OATP1B transporter activity. Data represent mean values (symbols) and SD (error bars) …
View article: Figure 1 from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895
Figure 1 from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895 Open
Interaction of TL-895 with protein kinases. A, KINOMEscan of TL-895 (500 nmol/L) against 403 nonmutant kinases to determine a selectivity score S(35) of 0.015. B, Kinase profiling of TL-895 against BTK and BMX revealed EC50 values of 3.02 …
View article: Table 2 from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895
Table 2 from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895 Open
Pharmacokinetic DDIs induced by TL-895 in mice
View article: Supplementary Figure S3 from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895
Supplementary Figure S3 from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895 Open
Pharmacokinetic profile of TL-895 in C57BL/6 and NSG mice. TL-895 plasma concentrations were determined in male and female mice on a C57BL/6 (A) or NSG (B) background strain. Mice received a single oral dose of 3 or 10 mg/kg. Data represen…
View article: Supplementary Figure S1 from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895
Supplementary Figure S1 from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895 Open
Positive control inhibition of BTK and BMX in NanoBRET assay. BRET luciferase response of BTK and BMX in the presence of CTx-0294885 or dasatinib, respectively, in HEK293 cells expressing BTK- and BMX-NanoLuc Fusion Vector showing EC50 val…
View article: Supplementary Methods from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895
Supplementary Methods from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895 Open
Supplementary Methods
View article: Data from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895
Data from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895 Open
TL-895 is an orally administered protein kinase inhibitor in clinical development for the treatment of B-cell malignancies and various other blood and autoimmune disorders. In the early stages of drug development, limited data are availabl…
View article: Figure 2 from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895
Figure 2 from Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895 Open
In vitro transport and transport inhibition by TL-895. Competitive counterflow of [3H]-EβG efflux in the presence or absence of TL-895 or unlabeled EβG in HEK293 cells overexpressing (A) OATP1B1 or (B) OATP1B3. Data represent mean values (…
View article: Wise Leadership And Its Role In Mitigating Workplace Bullying Behaviors: An Exploratory Study Perspectives Of A Sample Of Administrative Leaders At The University of Mosul
Wise Leadership And Its Role In Mitigating Workplace Bullying Behaviors: An Exploratory Study Perspectives Of A Sample Of Administrative Leaders At The University of Mosul Open
This descriptive survey examined the moderating effect of wise leadership on workplace bullying in a sample of administrative heads at the University of Mosul. To fill a notable gap in the literature concerning how wise leadership influenc…
View article: Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895
Drug–Drug Interaction Liabilities with BTK Inhibitor TL-895 Open
TL-895 is an orally administered protein kinase inhibitor in clinical development for the treatment of B-cell malignancies and various other blood and autoimmune disorders. In the early stages of drug development, limited data are availabl…
View article: A Pilot Metabolomic Study for Diagnosing Aspergillus Infection in Immunocompromised Pediatric Cancer Patients
A Pilot Metabolomic Study for Diagnosing Aspergillus Infection in Immunocompromised Pediatric Cancer Patients Open
Fungal infection caused by invasive Aspergillus is a life-threatening complication in immunocompromised pediatric cancer patients. However, the early diagnosis of invasive infection remains a clinical challenge due to the lack of specific,…
View article: Figure S2 from OATP1B-type Transport Function Is a Determinant of Aromatase Inhibitor–Associated Arthralgia Susceptibility
Figure S2 from OATP1B-type Transport Function Is a Determinant of Aromatase Inhibitor–Associated Arthralgia Susceptibility Open
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View article: Supplementary documents from OATP1B-type Transport Function Is a Determinant of Aromatase Inhibitor–Associated Arthralgia Susceptibility
Supplementary documents from OATP1B-type Transport Function Is a Determinant of Aromatase Inhibitor–Associated Arthralgia Susceptibility Open
Supplemental materials
View article: Figure S6 from OATP1B-type Transport Function Is a Determinant of Aromatase Inhibitor–Associated Arthralgia Susceptibility
Figure S6 from OATP1B-type Transport Function Is a Determinant of Aromatase Inhibitor–Associated Arthralgia Susceptibility Open
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View article: Figure S1 from OATP1B-type Transport Function Is a Determinant of Aromatase Inhibitor–Associated Arthralgia Susceptibility
Figure S1 from OATP1B-type Transport Function Is a Determinant of Aromatase Inhibitor–Associated Arthralgia Susceptibility Open
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View article: Figure S4 from OATP1B-type Transport Function Is a Determinant of Aromatase Inhibitor–Associated Arthralgia Susceptibility
Figure S4 from OATP1B-type Transport Function Is a Determinant of Aromatase Inhibitor–Associated Arthralgia Susceptibility Open
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View article: Figure S5 from OATP1B-type Transport Function Is a Determinant of Aromatase Inhibitor–Associated Arthralgia Susceptibility
Figure S5 from OATP1B-type Transport Function Is a Determinant of Aromatase Inhibitor–Associated Arthralgia Susceptibility Open
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View article: Figure S3 from OATP1B-type Transport Function Is a Determinant of Aromatase Inhibitor–Associated Arthralgia Susceptibility
Figure S3 from OATP1B-type Transport Function Is a Determinant of Aromatase Inhibitor–Associated Arthralgia Susceptibility Open
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View article: Modulating Effects of L-Arginine and Tribulus terrestris Extract on Fipronil-Induced Interference in the Male Reproductive System of Rats: Antioxidant Potential, Androgen Receptors, and Nitric Oxide Synthase Interplay
Modulating Effects of L-Arginine and Tribulus terrestris Extract on Fipronil-Induced Interference in the Male Reproductive System of Rats: Antioxidant Potential, Androgen Receptors, and Nitric Oxide Synthase Interplay Open
The protective potentials of Tribulus terrestris (TT) and L-arginine (L-Arg) against reproductive toxicity induced by fipronil (FPN) in male rats were investigated. A total of 36 male rats were allocated into six groups: control, TT, L-Arg…
View article: Role of liver X receptor in multiple sclerosis: A long furtive life behind a barrier
Role of liver X receptor in multiple sclerosis: A long furtive life behind a barrier Open
Liver X receptors (LXRs) are nuclear receptors that function as transcription factors regulating cholesterol metabolism and are implicated in multiple sclerosis (MS) pathogenesis. This mini-review aims to elucidate the potential role of LX…
View article: The Possible Role of Metformin and Fibroblast Growth Factor‐21 in Multiple Sclerosis Neuropathology: Birds of a Feather Flock Together
The Possible Role of Metformin and Fibroblast Growth Factor‐21 in Multiple Sclerosis Neuropathology: Birds of a Feather Flock Together Open
Multiple sclerosis (MS) is a progressive demyelinating disease of the CNS, characterized by inflammation, the formation of CNS plaques, and damage to the neuronal myelin sheath (Graphical abstract). Fibroblast growth factor 21 (FGF21) is i…
View article: Figure S1 from OATP1B-type Transport Function Is a Determinant of Aromatase Inhibitor–Associated Arthralgia Susceptibility
Figure S1 from OATP1B-type Transport Function Is a Determinant of Aromatase Inhibitor–Associated Arthralgia Susceptibility Open
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