Helmi Sulaiman
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Meropenem dosing optimization on day 1 and steady state in critically ill patients without significant renal impairment Open
This study aimed to characterize meropenem pharmacokinetics and optimise dosing for the initial and steady state in critically ill patients. Adult patients receiving meropenem were recruited, with sampling performed on days 1 (Occasion 1) …
Unveiling Novel KRAS G12V Inhibitors: A Comprehensive Study Using Computer-aided Drug Design Approach Open
The KRAS G12V mutation is a formidable oncogenic driver implicated in the pathogenesis of several aggressive cancers, including pancreatic ductal adenocarcinoma, non-small cell lung cancer, and colorectal cancer. Overcoming the historical …
Healing Rates and Dressing Frequency of Silver Foam Dressings in Paediatric Burns: A Systemic Review and Meta-Analysis Open
Silver foam dressings have been extensively used in the management of burn injuries; however, its application in children requires elucidation. A literature search was conducted from database inception to October 2023. Eligible studies rep…
Evaluating governance and the role of international law in protecting natural resources: Space powers and the Moon Agreement Open
The renewed interest in lunar exploration has prompted a critical re-examination of the international legal framework governing the use of outer space resources. This article explores the role of international law, particularly the Moon Ag…
Adjunctive Nebulized Tobramycin versus Intravenous Antibiotics Alone in the Management of Ventilator-associated Pneumonia: A Systematic Review and Meta-Analysis Open
AIM: This study analyzes existing data on the efficacy and safety of adjunctive nebulized tobramycin (ANT) for treating ventilator-associated pneumonia (VAP). Background: VAP presents a significant management challenge in intensive care un…
Pharmacist-Led Interventions for Reducing Polypharmacy and Improving Patient Outcomes: A Systematic Review Open
Objective: This systematic review aims to evaluate the impact of pharmacist-led interventions on reducing polypharmacy and improving patient outcomes. Given the risks associated with polypharmacy, especially among older adults, pharmacist-…
Audit of VTE prophylaxis risk assessment and prescribing for general medical inpatients Open
Venous thromboembolism is a significant cause of morbidity and mortalityamongst hospitalised patients. The aim was to review the current level ofcompleteness of venous thromboembolism (VTE) prophylaxis risk assessmentdocumentation at Surre…
View article: D-PRISM, a global study of diagnostic approaches in severe pneumonia.
D-PRISM, a global study of diagnostic approaches in severe pneumonia. Open
Purpose Pneumonia remains a significant global health concern, particularly among those requiring admission to the intensive care unit (ICU). Despite the availability of international guidelines there remains heterogeneity in clinical mana…
“Real-World” Evidence, Target Trial Emulation, and Randomized Clinical Trials—Which Data Should Clinicians Rely on When Choosing Antibiotics? Open
Sandra Tingsgård, MD; Simone Bastrup Israelsen, MD, PhD; Henrik Løvendahl Jørgensen, MD, PhD; Christian Østergaard, MD, DMSc; Thomas Benfield, MD, DMSc
2810. A synergy test to assess the activity of the Ceftazidime-Avibactam and Aztreonam combination: An experience from a single centre in Malaysia Open
Background Southeast Asia has a high prevalence of metallo-β-lactamase-producing carbapenem-resistant Enterobacterales (CRE). Ceftazidime-avibactam (CZA) and Aztreonam (ATM) combination is one of the preferred therapeutic options against t…
25 Brugada Syndrome – updates from an Irish Inherited Cardiac Conditions centre Open
Background Brugada syndrome (BrS) is usually considered to be an autosomal dominant genetic disorder with typical ECG findings of a pseudo right bundle branch block and ST segment elevation in V1-V3, associated with an increased risk of ar…
View article: ACORN (A Clinically-Oriented Antimicrobial Resistance Surveillance Network) II: protocol for case based antimicrobial resistance surveillance
ACORN (A Clinically-Oriented Antimicrobial Resistance Surveillance Network) II: protocol for case based antimicrobial resistance surveillance Open
Background : Antimicrobial resistance surveillance is essential for empiric antibiotic prescribing, infection prevention and control policies and to drive novel antibiotic discovery. However, most existing surveillance systems are isolate-…
Knowledge and practice survey of clinicians on the management of ventilator-associated pneumonia (VAP) in Malaysia Open
Background: Ventilator associated pneumonia (VAP) is the leading cause of high morbidity and mortality worldwide. Contemporary data suggest both the care bundles in VAP prevention, as well as clinical practice guideline can improve patient…
Knowledge, perception, and antibiotic prescribing practice in the intensive care unit: Findings from the malaysian public setting Open
Malaysian physicians are receptive to use PK/PD approach to optimize antibiotic dosing in ICU patients. Nonetheless, there are still gaps in the knowledge of antibiotic PK/PD as well as its application in the critically ill, especially for…
Is the risk of tenofovir‐induced nephrotoxicity similar in treatment‐naïve compared to treatment‐experienced patients? Open
Background Tenofovir disoproxil fumarate ( TDF ) is the recommended first‐line nucleoside reverse transcriptase inhibitor ( NRTI ) in the management of human immunodeficiency virus ( HIV ); however, its use is associated with nephrotoxicit…
Colistin only sensitive Acinetobacter baumanii infection involving prosthetic joints Open
Purpose: To describe the incidence and treatment response for Colistin only sensitive Acinetobacter Baumanii (CSAb) Prosthetic Joint infections (PJI) in a single tertiary centre. Methods & Materials: A retrospective study was performed. Al…
35 Prevalence of brugada syndrome in high risk irish population – data from cardiac risk in younger persons (CRYP), Tallaght, Dublin Open
Introduction Brugada Syndrome (BrS), first described by 2 Spanish brothers, is a genetic arrhythmogenic disease characterised by appearance of coved-shaped STelevation on electrocardiogram (ECG) in precordial leads V1–V3 in the absence of …
Human papillomavirus 16 (<span>HPV</span>16) and <span>HPV</span>52 E6‐specific immunity in <span>HIV</span>‐infected adults on combination antiretroviral therapy Open
Objectives Human papillomavirus ( HPV )‐associated cancers disproportionately affect those infected with HIV despite effective combination antiretroviral therapy (cART). The primary aim of this study was to quantify HPV 16 and HPV 52 E6‐sp…