Omid Vafa
YOU?
Author Swipe
View article: Perspective: Designing T-Cell Engagers With Better Therapeutic Windows
Perspective: Designing T-Cell Engagers With Better Therapeutic Windows Open
This perspective highlights the history and challenges of developing CD3-based bispecific T-cell engagers (TCEs) as cancer therapeutics as well as considerations and potential strategies for designing the next generation TCE molecules. The…
View article: Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies
Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies Open
T-cell-recruiting bispecific antibodies (T-BsAbs) have shown potent tumor killing activity in humans, but cytokine release-related toxicities have affected their clinical utility. The use of novel anti-CD3 binding domains with more favorab…
View article: Sequence-Based Discovery Demonstrates That Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of Antigen-Specific Antibodies
Sequence-Based Discovery Demonstrates That Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of Antigen-Specific Antibodies Open
We created a novel transgenic rat that expresses human antibodies comprising a diverse repertoire of heavy chains with a single common rearranged kappa light chain (IgKV3-15-JK1). This fixed light chain animal, called OmniFlic, presents a …