Wolfgang Omlor
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View article: Altered white matter microstructure of language pathways and semantic cognition deficiencies in early psychosis
Altered white matter microstructure of language pathways and semantic cognition deficiencies in early psychosis Open
View article: Goal-Directed Control in Schizophrenia: Loss-Biased Engagement of the Anterior Cingulate Relates to Negative-Symptom Outcomes
Goal-Directed Control in Schizophrenia: Loss-Biased Engagement of the Anterior Cingulate Relates to Negative-Symptom Outcomes Open
Background and Hypothesis Individuals with schizophrenia spectrum disorders (SSD) often show diminished reward pursuit, whereas loss avoidance is relatively preserved. The neural mechanisms of this dissociation and its relation to negative…
View article: Mapping the trajectory of psychotic symptoms and their interaction with antipsychotic treatment: a longitudinal network intervention study
Mapping the trajectory of psychotic symptoms and their interaction with antipsychotic treatment: a longitudinal network intervention study Open
Antipsychotic efficacy in schizophrenia spectrum disorders (SSD) is commonly evaluated using static measures that fail to capture the dynamic evolution of symptoms and the unfolding impact of treatment over time. Network Intervention Analy…
View article: Altered white matter microstructure of language pathways and semantic cognition deficiencies in early psychosis
Altered white matter microstructure of language pathways and semantic cognition deficiencies in early psychosis Open
Background Semantic language dysfunction is a hallmark of early psychosis, yet the underlying brain structural correlates are largely unexplored. In particular, it is unclear whether core deficits arise from disruptions to semantic represe…
View article: Thalamocortical Structural Covariation Networks Are Related to Familial Risk for Schizophrenia in the Context of Lower Nuclei Volume Estimates in Patients: An ENIGMA Study
Thalamocortical Structural Covariation Networks Are Related to Familial Risk for Schizophrenia in the Context of Lower Nuclei Volume Estimates in Patients: An ENIGMA Study Open
View article: Genetic susceptibility to schizophrenia through neuroinflammatory pathways associated with retinal thinness
Genetic susceptibility to schizophrenia through neuroinflammatory pathways associated with retinal thinness Open
View article: Exploratory analysis of the relationship between striatal connectivity and apathy during phosphodiesterase 10 inhibition in schizophrenia: findings from a randomized crossover trial
Exploratory analysis of the relationship between striatal connectivity and apathy during phosphodiesterase 10 inhibition in schizophrenia: findings from a randomized crossover trial Open
View article: An exploratory network analysis to investigate schizotypy’s structure using the ‘Multidimensional Schizotypy Scale’ and ‘Oxford-Liverpool Inventory’ in a healthy cohort
An exploratory network analysis to investigate schizotypy’s structure using the ‘Multidimensional Schizotypy Scale’ and ‘Oxford-Liverpool Inventory’ in a healthy cohort Open
View article: Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm
Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm Open
Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations of mental disorders. Here we analyzed cross-sectional brain images from 4,222 individuals with schizophrenia and 7038 healthy …
View article: Investigating the structure of Schizotypy through the “Multidimensional Schizotypy Scale” and “Oxford-Liverpool Inventory”: an Exploratory network analysis approach in the healthy population
Investigating the structure of Schizotypy through the “Multidimensional Schizotypy Scale” and “Oxford-Liverpool Inventory”: an Exploratory network analysis approach in the healthy population Open
Background Schizophrenia spectrum disorders and schizotypy share traits across positive, negative, and disorganized domains. Instruments like MSS and O-LIFE provide insights into these dimensions. Despite challenges posed by cultural varia…
View article: Relationship between Striatal Connectivity and Apathy during Phosphodiesterase 10 Inhibition in Schizophrenia
Relationship between Striatal Connectivity and Apathy during Phosphodiesterase 10 Inhibition in Schizophrenia Open
Negative symptoms in schizophrenia remain a challenge with limited therapeutic strategies. The novel compound RG7203 promotes reward learning via dopamine D1-dependent signaling and therefore holds promise to improve especially the apathy …
View article: Genetic susceptibility to schizophrenia through neuroinflammatory pathways is associated with retinal thinning: Findings from the UK-Biobank
Genetic susceptibility to schizophrenia through neuroinflammatory pathways is associated with retinal thinning: Findings from the UK-Biobank Open
The human retina is part of the central nervous system and can be easily and non-invasively imaged with optical coherence tomography. While imaging the retina may provide insights on central nervous system-related disorders such as schizop…
View article: Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study
Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study Open
Schizophrenia is a prototypical network disorder with widespread brain-morphological alterations, yet it remains unclear whether these distributed alterations robustly reflect the underlying network layout. We tested whether large-scale st…
View article: Two neurostructural subtypes: results of machine learning on brain images from 4,291 individuals with schizophrenia
Two neurostructural subtypes: results of machine learning on brain images from 4,291 individuals with schizophrenia Open
Machine learning can be used to define subtypes of psychiatric conditions based on shared clinical and biological foundations, presenting a crucial step toward establishing biologically based subtypes of mental disorders. With the goal of …
View article: Neural Correlates of Positive and Negative Formal Thought Disorder in Individuals with Schizophrenia: An ENIGMA Schizophrenia Working Group Study
Neural Correlates of Positive and Negative Formal Thought Disorder in Individuals with Schizophrenia: An ENIGMA Schizophrenia Working Group Study Open
View article: Estimating multimodal brain variability in schizophrenia spectrum disorders: A worldwide ENIGMA study
Estimating multimodal brain variability in schizophrenia spectrum disorders: A worldwide ENIGMA study Open
Objective Schizophrenia is a multifaceted disorder associated with structural brain heterogeneity. Despite its relevance for identifying illness subtypes and informative biomarkers, structural brain heterogeneity in schizophrenia remains i…
View article: Neural Correlates of Positive and Negative Formal Thought Disorder in Individuals with Schizophrenia: An ENIGMA Schizophrenia Working Group Study
Neural Correlates of Positive and Negative Formal Thought Disorder in Individuals with Schizophrenia: An ENIGMA Schizophrenia Working Group Study Open
Formal thought disorder (FTD) is a key clinical factor in schizophrenia, but the neurobiological underpinnings remain unclear. In particular, relationship between FTD symptom dimensions and patterns of regional brain volume deficiencies in…
View article: Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study
Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study Open
While schizophrenia is considered a prototypical network disorder characterized by widespread brain-morphological alterations, it still remains unclear whether distributed structural alterations robustly reflect underlying network layout. …
View article: Context-dependent limb movement encoding in neuronal populations of motor cortex
Context-dependent limb movement encoding in neuronal populations of motor cortex Open
View article: Context-dependent limb movement encoding in neuronal populations of motor cortex
Context-dependent limb movement encoding in neuronal populations of motor cortex Open
Neuronal networks of the mammalian motor cortex (M1) are important for dexterous control of limb joints. Yet it remains unclear how encoding of joint movement in M1 networks depends on varying environmental contexts. Using calcium imaging …
View article: Sodium Oxybate for Excessive Daytime Sleepiness and Sleep Disturbance in Parkinson Disease
Sodium Oxybate for Excessive Daytime Sleepiness and Sleep Disturbance in Parkinson Disease Open
clinicaltrials.gov Identifier: NCT02111122.
View article: Motor cortex encodes forelimb joint movements according to contextual relevance
Motor cortex encodes forelimb joint movements according to contextual relevance Open
Primary motor cortex (M1) contributes to the control of limb movements which have to be applied not only in isolation but also within purposeful sequences during everyday life. How the M1 neuronal network encodes motion of individual limb …