Omnia A. M. Abd El‐Ghafar
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View article: Candesartan preserves aortic structure and function in cisplatin-treated rats by upregulating SIRT1/Nrf2/HO-1 signaling and suppressing oxidative stress, TLR-4/NF-κB signaling, and necroptosis
Candesartan preserves aortic structure and function in cisplatin-treated rats by upregulating SIRT1/Nrf2/HO-1 signaling and suppressing oxidative stress, TLR-4/NF-κB signaling, and necroptosis Open
Background Cisplatin (CIS) is widely used in the treatment of several tumors. However, its use is associated with toxicity that contributes to long-term cardiovascular complications in cancer survivors. This study investigated whether the …
View article: S-Carboxymethylcysteine Mitigates Cyclophosphamide-Induced Hepatotoxicity by Modulating TLR-4/NF-κB Signaling and Redox Homeostasis
S-Carboxymethylcysteine Mitigates Cyclophosphamide-Induced Hepatotoxicity by Modulating TLR-4/NF-κB Signaling and Redox Homeostasis Open
View article: Ambroxol mitigates cyclophosphamide-induced liver injury by suppressing TLR-4/NF-κB signaling and oxidative stress and upregulating cytoglobin, TXNRD1 and HMGB1
Ambroxol mitigates cyclophosphamide-induced liver injury by suppressing TLR-4/NF-κB signaling and oxidative stress and upregulating cytoglobin, TXNRD1 and HMGB1 Open
BACKGROUND Cyclophosphamide (CP) is a potent chemotherapeutic and immunosuppressant agent, but its hepatotoxicity remains a significant concern. Ambroxol (ABX) is a mucolytic agent with emerging beneficial effects against oxidative stress …
View article: <i>Plantago boissieri</i>: Phytochemical Assessment, Antioxidant, Anti‐inflammatory and Wound Healing Potential
<i>Plantago boissieri</i>: Phytochemical Assessment, Antioxidant, Anti‐inflammatory and Wound Healing Potential Open
Plantago is a large genus under family Plantaginaceae. Several Plantago species were noted for potent antioxidant, anti‐inflammatory and wound healing activities. The current research investigated the potential bioactivities as well as the…
View article: Diallyl Disulfide Mitigates Cadmium Hepatotoxicity by Attenuating Oxidative Stress and TLR-4/NF-κB Signaling and Upregulating PPARγ
Diallyl Disulfide Mitigates Cadmium Hepatotoxicity by Attenuating Oxidative Stress and TLR-4/NF-κB Signaling and Upregulating PPARγ Open
Background: Heavy metals can cause serious health problems that affect different organs. Cadmium (Cd) is an environmental contaminant known for its toxicological consequences on different organs. Hepatotoxicity is a serious effect of expos…
View article: Nano Methotrexate versus Methotrexate in Targeting Rheumatoid Arthritis
Nano Methotrexate versus Methotrexate in Targeting Rheumatoid Arthritis Open
Nanomedicine has emerged as an important approach for targeting RA medication. Rheumatoid arthritis (RA) is a widespread autoimmune disorder marked by multiple inflamed joints. Gold nanoparticles (GNPs) have been demonstrated as efficaciou…
View article: Azithromycin Mitigates Cisplatin-Induced Lung Oxidative Stress, Inflammation and Necroptosis by Upregulating SIRT1, PPARγ, and Nrf2/HO-1 Signaling
Azithromycin Mitigates Cisplatin-Induced Lung Oxidative Stress, Inflammation and Necroptosis by Upregulating SIRT1, PPARγ, and Nrf2/HO-1 Signaling Open
Acute lung injury (ALI) is one of the adverse effects of the antineoplastic agent cisplatin (CIS). Oxidative stress, inflammation, and necroptosis are linked to the emergence of lung injury in various disorders. This study evaluated the ef…
View article: Correction: Hassanein EHM, Ahmed MA, Sayed AM, Rashwan EK, Abd El‐Ghafar OAM, Mahmoud AM. Edaravone mitigates hemorrhagic cystitis by modulating Nrf2, TLR‐4/NF‐κB, and JAK1/STAT3 signaling in cyclophosphamide‐intoxicated rats. J Biochem Mol Toxicol. 2021 Nov;35(11):E22889
Correction: Hassanein EHM, Ahmed MA, Sayed AM, Rashwan EK, Abd El‐Ghafar OAM, Mahmoud AM. Edaravone mitigates hemorrhagic cystitis by modulating Nrf2, TLR‐4/NF‐κB, and JAK1/STAT3 signaling in cyclophosphamide‐intoxicated rats. J Biochem Mol Toxicol. 2021 Nov;35(11):E22889 Open
Following the publication of this article,[1] it has come to our attention that in Figure 5 Panel D, the image representing the control group was accidentally replaced by the control group image from Figure 3A. The corrected Figure 5 is pr…
View article: Candesartan Attenuates Cisplatin-Induced Lung Injury by Modulating Oxidative Stress, Inflammation, and TLR-4/NF-κB, JAK1/STAT3, and Nrf2/HO-1 Signaling
Candesartan Attenuates Cisplatin-Induced Lung Injury by Modulating Oxidative Stress, Inflammation, and TLR-4/NF-κB, JAK1/STAT3, and Nrf2/HO-1 Signaling Open
Cisplatin (CIS) is an effective chemotherapeutic agent against different cancers. The use of CIS is associated with acute lung injury (ALI) and other adverse effects, and oxidative stress and inflammation were implicated in its toxic effec…
View article: The promising therapeutic potentials of ginsenosides mediated through p38 MAPK signaling inhibition
The promising therapeutic potentials of ginsenosides mediated through p38 MAPK signaling inhibition Open