Omnia El‐Badawy
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View article: The autophagy-regulator gene BECN1, T follicular regulatory and T follicular helper cell harmony in Acute Myeloid Leukemia
The autophagy-regulator gene BECN1, T follicular regulatory and T follicular helper cell harmony in Acute Myeloid Leukemia Open
Background Autophagy is a catabolic pathway with a controversial role regarding tumor suppression and promotion and is accused of suppressing the effect of several chemotherapeutic agents. Autophagy is also involved in regulating T cell fu…
View article: Impact of Sofosbuvir Plus Daclatasvir Therapy on the Frequency of CD200R+ Dendritic Cells in Chronic Hepatitis C Virus Infection
Impact of Sofosbuvir Plus Daclatasvir Therapy on the Frequency of CD200R+ Dendritic Cells in Chronic Hepatitis C Virus Infection Open
Dendritic cells (DCs) play a crucial role in controlling viral infections. Little is known about the changes in frequencies of the DC subsets in patients with chronic hepatitis C (CHC), particularly in the era of interferon-free regimens. …
View article: Memory T Cells Discrepancies in COVID-19 Patients
Memory T Cells Discrepancies in COVID-19 Patients Open
The immune response implicated in Coronavirus disease 2019 (COVID-19) pathogenesis remains to be fully understood. The present study aimed to clarify the alterations in CD4+ and CD8+ memory T cells’ compartments in SARS-CoV-2-infected pati…
View article: Variations in levels of ACE2 and TMPRSS2 receptors among COVID-19
Variations in levels of ACE2 and TMPRSS2 receptors among COVID-19 Open
Background: Key actors in SARS-CoV-2 entrance into host cells include angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2). Our objective was to study gene expression of those key actors in COVID-19 patients…
View article: Could the Crosstalk Between Myeloid-Derived-Suppressor Cells and Regulatory T Cells Have a Role in Beta-Thalassemia?
Could the Crosstalk Between Myeloid-Derived-Suppressor Cells and Regulatory T Cells Have a Role in Beta-Thalassemia? Open
Levels of Tregs and MDSCs increased in TDT and may probably have a role in suppressing the active immune systems of TDT patients.
View article: Genetic Variability, Multivariate and Association Analysis for Agronomic Traits in Different Rice Genotypes
Genetic Variability, Multivariate and Association Analysis for Agronomic Traits in Different Rice Genotypes Open
The current study aimed to evaluate the presence of variability for desired traits and to estimate genetic parameters (phenotypic and genotypic coefficients of variation, broad sense heritability), correlations and principal component anal…
View article: pKpQIL-like plasmid contributes to the dissemination of bla NDM-1 and plasmid mediated quinolone resistance determinants among multi drug resistant Klebsiella pneumoniae in Assiut university hospital, Egypt
pKpQIL-like plasmid contributes to the dissemination of bla NDM-1 and plasmid mediated quinolone resistance determinants among multi drug resistant Klebsiella pneumoniae in Assiut university hospital, Egypt Open
Background and Objectives: Concomitant carriage of bla NDM-1 and plasmid mediated quinolone resistance determinants (PMQRs) by multi drug resistant (MDR) Klebsiella pneumoniae (K. pneumoniae) has increased globally, often related to their …
View article: Imbalance of Follicular Helper and Follicular Regulatory T Cells in Chronic Rhinosinusitis with Nasal Polyps
Imbalance of Follicular Helper and Follicular Regulatory T Cells in Chronic Rhinosinusitis with Nasal Polyps Open
An imbalance in circulating Tfh/Tfr levels was detected in patients having CRSwNP. A significant rise in the levels of Tfh and Tfr was detected in patients proposing a possible role of this imbalance in disease pathogenesis.
View article: The Controversial Role of Autophagy in AML/ Cancer: Review Article
The Controversial Role of Autophagy in AML/ Cancer: Review Article Open
Background: A catabolic process that has been preserved throughout evolution, autophagy sends cytoplasmic proteins, organelles, and bacteria to lysosomes for destruction.Within its subtypes, acute myeloid leukaemia (AML) exhibits a signifi…
View article: Increased percentage of apoptotic and CTLA-4 (CD152) expressing cells in CD4+/CD8+ cells in COVID-19 patients
Increased percentage of apoptotic and CTLA-4 (CD152) expressing cells in CD4+/CD8+ cells in COVID-19 patients Open
Coronavirus infectious disease 2019 (COVID-19) confirmed cases are characterized by T lymphopenia. Total apoptotic and cytotoxic T-lymphocyte antigen-4 (CTLA-4) expressing cells among CD4 + /CD8 + cells were analyzed in 24 COVID-19 patient…
View article: AN OVERVIEW OF B CELL IMMUNOMODULATORY ROLE IN NORMAL PREGNANCY AND PREECLAMPSIA
AN OVERVIEW OF B CELL IMMUNOMODULATORY ROLE IN NORMAL PREGNANCY AND PREECLAMPSIA Open
During pregnancy, the key determinant to pregnancy success is the response of the maternal immune system towards the semi-allogeneic fetus.The pregnant uterus produces numerous cytokines such as interleukin (IL)-10 and transforming growth …
View article: Association of follicular helper T and follicular regulatory T cells with severity and hyperglycemia in hospitalized COVID-19 patients
Association of follicular helper T and follicular regulatory T cells with severity and hyperglycemia in hospitalized COVID-19 patients Open
We aimed to determine the levels of follicular helper T (Tfh) and follicular regulatory T (Tfr) cells in COVID-19 patients and determine whether their levels correlated with disease severity and presence of hyperglycemia. This study was ca…
View article: Overexpression of PD-1 and CD39 in tumor-infiltrating lymphocytes compared with peripheral blood lymphocytes in triple-negative breast cancer
Overexpression of PD-1 and CD39 in tumor-infiltrating lymphocytes compared with peripheral blood lymphocytes in triple-negative breast cancer Open
Background and aim Growing evidence highlighted the primary role of the immune system in the disease course of triple-negative breast cancer (TNBC). The study aim was to investigate the expression of PD-1 and CD39 on CD4 + and CD8 + cells …
View article: COVID-19 Infection in Patients with Comorbidities: Clinical and Immunological Insight
COVID-19 Infection in Patients with Comorbidities: Clinical and Immunological Insight Open
Aim Our study's objectives were to study the clinical and laboratory characteristics that may serve as biomarkers for predicting disease severity, IL-10 levels, and frequencies of different T cell subsets in comorbid COVID-19 patients. Met…
View article: ROLE OF MUCOSAL-ASSOCIATED INVARIANT T CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUS
ROLE OF MUCOSAL-ASSOCIATED INVARIANT T CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUS Open
The etiology of inflammatory and autoimmune diseases is complex and not yet fully understood. Their pathogenesis includes mechanisms in which both innate and adaptive immune cells are involved. Mucosal-associated invariant T (MAIT) cells a…
View article: DIFFERENTIAL CYTOKINE PROFILES IN PATIENTS WITH VIRAL AND NON-VIRAL RELATED LIVER CIRRHOSIS
DIFFERENTIAL CYTOKINE PROFILES IN PATIENTS WITH VIRAL AND NON-VIRAL RELATED LIVER CIRRHOSIS Open
Cytokines are pleiotropic peptides that are produced by nearly every nucleated cell in the human body.The liver is one of the most affected tissues.Hepatic inflammation, apoptosis and necrosis of liver cells, cholestasis, fibrosis, and cir…
View article: Evaluation of antimicrobial and synergistic effects of some medicinal plant extracts on antimicrobial resistant organisms
Evaluation of antimicrobial and synergistic effects of some medicinal plant extracts on antimicrobial resistant organisms Open
Unlike synthetic medications, natural-source compounds have fewer side effects, are less expensive, come from renewable sources, and have a higher level of acceptance due to their long history of use.Many of today's medications are based on
View article: Accumulation of Regulatory T Cells in Triple Negative Breast Cancer Can Boost Immune Disruption
Accumulation of Regulatory T Cells in Triple Negative Breast Cancer Can Boost Immune Disruption Open
The findings of the current study support the possibility that TNBC microenvironment conveys specific characteristics on Tregs distinguishing them from those in normal breast tissue or Tregs in peripheral blood, improving the capabilities …
View article: Role of Mucosal-Associated Invariant T Cells in Systemic Lupus Erythematosus
Role of Mucosal-Associated Invariant T Cells in Systemic Lupus Erythematosus Open
The etiology of inflammatory and autoimmune diseases is complex and not yet fully understood. Their pathogenesis includes mechanisms in which both innate and adaptive immune cells are involved. Mucosal-associated invariant T (MAIT) cells a…
View article: Differential alterations in peripheral lymphocyte subsets in COVID-19 patients: upregulation of double-positive and double-negative T cells
Differential alterations in peripheral lymphocyte subsets in COVID-19 patients: upregulation of double-positive and double-negative T cells Open
Background: Viral infections cause alteration in the total number of lymphocytes and their subset distribution. We aimed to study peripheral blood lymphocyte subsets in COVID-19 patients and to correlate these subsets with clinical and lab…
View article: Circulating microparticles and activated platelets as novel prognostic biomarkers in COVID-19; relation to cancer
Circulating microparticles and activated platelets as novel prognostic biomarkers in COVID-19; relation to cancer Open
Background and aim The study aimed to determine whether the MPs levels and platelet activation are affected by the COVID-19 infection in both malignant and non-malignant patients compared to healthy individuals and define their contributio…
View article: Could the Crosstalk Between Mdscs and Tregs Have a Role in β-thalassemia?
Could the Crosstalk Between Mdscs and Tregs Have a Role in β-thalassemia? Open
Background: Secondary-iron overload, alloimmunization, and increased risk of infections are common complications in β-thalassemia major (BTM) patients. Tregs and myeloid-derived suppressor cells (MDSCs) play an essential role in preventing…
View article: Wheat bran as a natural remedy for COVID-19
Wheat bran as a natural remedy for COVID-19 Open
COVID-19 severity is not only due to the viral infection but also due to the host immune responses.Destructive inflammatory responses are intensely implicated in airway damage.Besides, the massive release of cytokines, including interleuki…
View article: Upregulation of CD146 in Pediatric B‐Cell Acute Lymphocytic Leukemia and Its Implications on Treatment Outcomes
Upregulation of CD146 in Pediatric B‐Cell Acute Lymphocytic Leukemia and Its Implications on Treatment Outcomes Open
Background and Aim . We studied through flow cytometry the expression of CD146 on different T cells, and B‐cell ALL blasts trying to correlate its expression with different prognostic factors of B‐cell ALL and treatment outcomes. Patients …