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View article: Repurposing of FDA-Approved Antiviral Drugs Against Monkeypox Virus: Comparative In Vitro Screening and Structure Based In Silico Studies
Repurposing of FDA-Approved Antiviral Drugs Against Monkeypox Virus: Comparative In Vitro Screening and Structure Based In Silico Studies Open
Background/Objectives: Monkeypox is endemic to the African continent and has recently garnered global attention due to reported outbreaks in non-endemic nations. No approved drug is available for non-severe cases, and some isolates gained …
View article: Genetic Characterization and Pathogenesis of Highly Pathogenic Avian Influenza Virus A (H5N1) Isolated in Egypt During 2021–2023
Genetic Characterization and Pathogenesis of Highly Pathogenic Avian Influenza Virus A (H5N1) Isolated in Egypt During 2021–2023 Open
Highly pathogenic avian influenza (HPAI) viruses have recently had a substantial impact on global poultry production and public health. In Egypt, clade 2.3.4.4b HPAI H5N1 viruses were first isolated from wild birds in 2021 and then became …
View article: Author Correction: Antiviral potential of Melissa officinalis extracts against influenza and emerging coronaviruses
Author Correction: Antiviral potential of Melissa officinalis extracts against influenza and emerging coronaviruses Open
View article: In vitro evaluation of antimicrobial, antitumor, and anti-SARS-cov-2 properties of cellulase enzyme produced by Aspergillus niger
In vitro evaluation of antimicrobial, antitumor, and anti-SARS-cov-2 properties of cellulase enzyme produced by Aspergillus niger Open
Cellulase derived from A. niger presents significant biological potential, including antibiofilm, anticancer, immunomodulatory, and antiviral properties. These findings suggest promising applications of microbial cellulase in therap…
View article: Antiviral potential of Melissa officinalis extracts against influenza and emerging coronaviruses
Antiviral potential of Melissa officinalis extracts against influenza and emerging coronaviruses Open
Melissa officinalis is a perennial medicinal plant traditionally used for its diverse biological activities, including antiviral properties. This study investigates the antiviral efficacy of various extracts, including water, acetone, alka…
View article: Emergence of a novel reassortant highly pathogenic avian influenza clade 2.3.4.4b A(H5N2) Virus, 2024
Emergence of a novel reassortant highly pathogenic avian influenza clade 2.3.4.4b A(H5N2) Virus, 2024 Open
Reassortant highly pathogenic avian influenza A(H5N2) clade 2.3.4.4.b viruses were detected from ducks and environmental samples in Egypt, June 2024. Genomic and phylogenetic analyses revealed a novel genotype produced by the reassortment …
View article: Combating COVID-19 and its co-infection by Aspergillus tamarii SP73-EGY using in vitro and in silico Studies
Combating COVID-19 and its co-infection by Aspergillus tamarii SP73-EGY using in vitro and in silico Studies Open
View article: Triterpene saponins from the halophyte <i>Anabasis setifera</i> exhibit anti-SARS-CoV-2 properties
Triterpene saponins from the halophyte <i>Anabasis setifera</i> exhibit anti-SARS-CoV-2 properties Open
Halophytes are well-known as a rich source of health-promoting phytochemicals.
View article: <b>Newcastle disease virus in Egyptian domestic poultry, 2019–2021: Molecular characterization, phylogenetic analysis, and coinfection with avian influenza A virus</b>
<b>Newcastle disease virus in Egyptian domestic poultry, 2019–2021: Molecular characterization, phylogenetic analysis, and coinfection with avian influenza A virus</b> Open
Background: Newcastle Disease Virus (NDV) is a major viral disease of poultry that causes outbreaks in chickens in Egypt. Aim: The aim of this study was to determine the prevalence and molecular characteristics of NDV and its cocirculation…
View article: Genetic and pathogenic potential of highly pathogenic avian influenza H5N8 viruses from live bird markets in Egypt in avian and mammalian models
Genetic and pathogenic potential of highly pathogenic avian influenza H5N8 viruses from live bird markets in Egypt in avian and mammalian models Open
Since its first isolation from migratory birds in Egypt in 2016, highly pathogenic avian influenza (HPAI) H5N8 has caused several outbreaks among domestic poultry in various areas of the country affecting poultry health and production syst…
View article: Highly pathogenic avian influenza virus H5N1 clade 2.3.4.4b in wild rats in Egypt during 2023
Highly pathogenic avian influenza virus H5N1 clade 2.3.4.4b in wild rats in Egypt during 2023 Open
We detected highly pathogenic avian influenza A(H5N1) virus in wild rats collected from a rural area in Giza, Egypt, near poultry farms, markets, and backyard flocks. Sequence and phylogenetic analyses indicated that the virus from the rat…
View article: Drug repurposing of pyrazolotriazine derivatives as potential anti-SARS-CoV-2 agents: in vitro and in silico studies
Drug repurposing of pyrazolotriazine derivatives as potential anti-SARS-CoV-2 agents: in vitro and in silico studies Open
View article: Comparative metabolomics analysis of Citrus medica var. sarcodactylis Swingle and Limonia acidissima Linn. Fruits and leaves cultivated in Egypt in context to their antiviral effects
Comparative metabolomics analysis of Citrus medica var. sarcodactylis Swingle and Limonia acidissima Linn. Fruits and leaves cultivated in Egypt in context to their antiviral effects Open
A comprehensive study of fruits and leaves extracts of Citrus medica var. sarcodactylis Swingle and Limonia acidissima L. family Rutaceae was accomplished to investigate their antiviral activity along with their zinc o…
View article: Eucalyptus Oils Phytochemical Composition in Correlation with Their Newly Explored Anti-SARS-CoV-2 Potential: in Vitro and in Silico Approaches
Eucalyptus Oils Phytochemical Composition in Correlation with Their Newly Explored Anti-SARS-CoV-2 Potential: in Vitro and in Silico Approaches Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the latest arisen contagious respiratory pathogen related to the global outbreak of atypical pneumonia pandemic (COVID-19). The essential oils (EOs) of Eucalyptus camaldulensi…
View article: Novel Inhalable Nano-Based/Microparticles for Enhanced Sustained Pulmonary Delivery of Remdesivir - a Patient Malleable Treatment for Coronaviruses Infection: In Vitro Aerosolization, Cytotoxicity Assays and Antiviral Activity Studies
Novel Inhalable Nano-Based/Microparticles for Enhanced Sustained Pulmonary Delivery of Remdesivir - a Patient Malleable Treatment for Coronaviruses Infection: In Vitro Aerosolization, Cytotoxicity Assays and Antiviral Activity Studies Open
View article: Biological and computational assessments of thiazole derivative-reinforced bile salt enriched nano carriers: a new gate in targeting SARS-CoV-2 spike protein
Biological and computational assessments of thiazole derivative-reinforced bile salt enriched nano carriers: a new gate in targeting SARS-CoV-2 spike protein Open
Thiazole derivative-reinforced bile salt enriched nano carriers: a new frontier in targeting SARS-CoV-2 spike protein.
View article: Potent Antiviral Activity of Vitamin B12 against Severe Acute Respiratory Syndrome Coronavirus 2, Middle East Respiratory Syndrome Coronavirus, and Human Coronavirus 229E
Potent Antiviral Activity of Vitamin B12 against Severe Acute Respiratory Syndrome Coronavirus 2, Middle East Respiratory Syndrome Coronavirus, and Human Coronavirus 229E Open
Repurposing vitamins as antiviral supporting agents is a rapid approach used to control emerging viral infections. Although there is considerable evidence supporting the use of vitamin supplementation in viral infections, including severe …
View article: Identification of potential antiviral compounds from Egyptian Red Sea soft corals against Middle East respiratory syndrome coronavirus
Identification of potential antiviral compounds from Egyptian Red Sea soft corals against Middle East respiratory syndrome coronavirus Open
The ongoing threat of Middle East respiratory syndrome coronavirus (MERS-CoV) underscores the importance of developing effective antiviral treatments. Current research was conducted to identify potential antiviral compounds from soft coral…
View article: Design and statistical optimisation of emulsomal nanoparticles for improved anti-SARS-CoV-2 activity of <i>N</i> -(5-nitrothiazol-2-yl)-carboxamido candidates: <i>in vitro</i> and <i>in silico</i> studies
Design and statistical optimisation of emulsomal nanoparticles for improved anti-SARS-CoV-2 activity of <i>N</i> -(5-nitrothiazol-2-yl)-carboxamido candidates: <i>in vitro</i> and <i>in silico</i> studies Open
In this article, emulsomes (EMLs) were fabricated to encapsulate the N-(5-nitrothiazol-2-yl)-carboxamido derivatives (3a-3g) in an attempt to improve their biological availability and antiviral activity. Next, both cyt…
View article: Virucidal effect of Moringa oleifera against SARS-CoV-2 and Influenza A/H1N1
Virucidal effect of Moringa oleifera against SARS-CoV-2 and Influenza A/H1N1 Open
In the last two decades, global human health problems and economic disasters have been brought on by many viruses, such as Severe acute respiratory syndrome coronavirus 1(SARS-CoV-1), Severe acute respiratory syndrome coronavirus 2 (SARS-C…
View article: Bio-guided chemical characterization and nano-formulation studies of selected edible volatile oils with potential antibacterial and anti-SARS-CoV-2 activities
Bio-guided chemical characterization and nano-formulation studies of selected edible volatile oils with potential antibacterial and anti-SARS-CoV-2 activities Open
The recent pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has opened the door to potential threats of the respiratory system. The discovery of drugs from natural sources is one of the most important strateg…
View article: Comparative pathogenic potential of avian influenza H7N3 viruses isolated from wild birds in Egypt and their sensitivity to commercial antiviral drugs
Comparative pathogenic potential of avian influenza H7N3 viruses isolated from wild birds in Egypt and their sensitivity to commercial antiviral drugs Open
View article: Active surveillance and genetic evolution of avian influenza viruses in Egypt, 2016–2018
Active surveillance and genetic evolution of avian influenza viruses in Egypt, 2016–2018 Open
Egypt is a hotspot for avian influenza virus (AIV) due to the endemicity of H5N1 and H9N2 viruses. AIVs were isolated from 329 samples collected in 2016–2018; 48% were H9N2, 37.1% were H5N8, 7.6% were H5N1, and 7.3% were co-infections with…
View article: Discovery of novel thioquinazoline-N-aryl-acetamide/N-arylacetohydrazide hybrids as anti-SARS-CoV-2 agents: Synthesis, in vitro biological evaluation, and molecular docking studies
Discovery of novel thioquinazoline-N-aryl-acetamide/N-arylacetohydrazide hybrids as anti-SARS-CoV-2 agents: Synthesis, in vitro biological evaluation, and molecular docking studies Open
View article: Investigating the Potential Anti-SARS-CoV-2 and Anti-MERS-CoV Activities of Yellow Necklacepod among Three Selected Medicinal Plants: Extraction, Isolation, Identification, In Vitro, Modes of Action, and Molecular Docking Studies
Investigating the Potential Anti-SARS-CoV-2 and Anti-MERS-CoV Activities of Yellow Necklacepod among Three Selected Medicinal Plants: Extraction, Isolation, Identification, In Vitro, Modes of Action, and Molecular Docking Studies Open
The anti-MERS-CoV activities of three medicinal plants (Azadirachta indica, Artemisia judaica, and Sophora tomentosa) were evaluated. The highest viral inhibition percentage (96%) was recorded for S. tomentosa. Moreover, the mode of action…
View article: Anticoagulants as Potential SARS-CoV-2 Mpro Inhibitors for COVID-19 Patients: In Vitro, Molecular Docking, Molecular Dynamics, DFT, and SAR Studies
Anticoagulants as Potential SARS-CoV-2 Mpro Inhibitors for COVID-19 Patients: In Vitro, Molecular Docking, Molecular Dynamics, DFT, and SAR Studies Open
In this article, 34 anticoagulant drugs were screened in silico against the main protease (Mpro) of SARS-CoV-2 using molecular docking tools. Idraparinux, fondaparinux, eptifibatide, heparin, and ticagrelor demonstrated the highest binding…
View article: Design, Synthesis and In Vitro Evaluation of Spirooxindole-Based Phenylsulfonyl Moiety as a Candidate Anti-SAR-CoV-2 and MERS-CoV-2 with the Implementation of Combination Studies
Design, Synthesis and In Vitro Evaluation of Spirooxindole-Based Phenylsulfonyl Moiety as a Candidate Anti-SAR-CoV-2 and MERS-CoV-2 with the Implementation of Combination Studies Open
The search for an effective anti-viral to inhibit COVID-19 is a challenge for the specialized scientific research community. This work investigated the anti-coronavirus activity for spirooxindole-based phenylsulfone cycloadducts in a singl…
View article: Anti-SARS-CoV-2 in vitro potential of Castor Oil Plant (Ricinus communis) Leaf Extract: In-Silico Virtual Evidence
Anti-SARS-CoV-2 in vitro potential of Castor Oil Plant (Ricinus communis) Leaf Extract: In-Silico Virtual Evidence Open
Background Ricinus communis L. is a medicinal plant displays valuable pharmacological properties. Diverse phytochemical constituents display valuable pharmacological properties, including antioxidant, antimicrobial, analgesic, antipyretic,…
View article: CCDC 2087292: Experimental Crystal Structure Determination
CCDC 2087292: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2087291: Experimental Crystal Structure Determination
CCDC 2087291: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …