Matthew Lee
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View article: Human-AI Collaboration in Clinical Reasoning: A UK Replication and Interaction Analysis
Human-AI Collaboration in Clinical Reasoning: A UK Replication and Interaction Analysis Open
Objective A paper from Goh et al found that a large language model (LLM) working alone outperformed American clinicians assisted by the same LLM in diagnostic reasoning tests [1]. We aimed to replicate this result in a UK setting and explo…
View article: Negative pressure wound therapy for surgical wounds healing by secondary intention is not cost-effective
Negative pressure wound therapy for surgical wounds healing by secondary intention is not cost-effective Open
Background Negative pressure wound therapy (NPWT) has been used in clinical practice for surgical wounds healing by secondary intention (SWHSI), despite limited evidence regarding its clinical effectiveness and cost-effectiveness. The aim …
View article: Recommendation for Standardized Exam for Nasal Obstruction
Recommendation for Standardized Exam for Nasal Obstruction Open
Introduction Nasal septal deviation, inferior turbinate hypertrophy, and nasal valve compromise are among the most common etiologies of NAO seen by facial plastic surgeons and otolaryngologists. Discussion While both validated and non‐vali…
View article: Smartphone-based digital point-of-care panel assay with enzymatic catalytic reaction
Smartphone-based digital point-of-care panel assay with enzymatic catalytic reaction Open
The recent pandemic improved awareness amongst the public of the need for rapid blood tests for community and home settings. In this work, we evaluated the performance of a digital, lipid panel test in microfluidic assay format which can b…
View article: Step-by-step robotic intracorporeal orthotopic neobladder formation
Step-by-step robotic intracorporeal orthotopic neobladder formation Open
Objective: Radical cystectomy with urinary diversion is the standard of care for management of muscle invasive bladder cancer. In appropriately selected patients, orthotopic neobladder formation may offer benefits including preserved body …
View article: Measurement of Low Energy Nuclear Recoil Events with the phonon-mediated Voltage-Assisted Hybrid Detector for Rare Event Searches
Measurement of Low Energy Nuclear Recoil Events with the phonon-mediated Voltage-Assisted Hybrid Detector for Rare Event Searches Open
The phonon-mediated hybrid detector is made out of a monolithic silicon crystal characterized by two interconnected regions linked through a narrow neck. Operating solely on phonon signal measurements, the hybrid design facilitates the dif…
View article: Cytometry Masked Autoencoder: An Accurate and Interpretable Automated Immunophenotyper
Cytometry Masked Autoencoder: An Accurate and Interpretable Automated Immunophenotyper Open
High-throughput single-cell cytometry data are crucial for understanding involvement of immune system in diseases and responses to treatment. Traditional methods for annotating cytometry data, specifically manual gating and clustering, fac…
View article: Glioblastoma vulnerability to neddylation inhibition is dependent on PTEN status, and dysregulation of the cell cycle and DNA replication
Glioblastoma vulnerability to neddylation inhibition is dependent on PTEN status, and dysregulation of the cell cycle and DNA replication Open
Background Neddylation (NAE) inhibition, affecting posttranslational protein function and turnover, is a promising therapeutic approach to cancer. We report the cytotoxic vulnerability to NAE inhibitors in a subset of glioblastoma (GBM) pr…
View article: FTP5.2 Functional deficits in older patients undergoing major gastrointestinal surgery
FTP5.2 Functional deficits in older patients undergoing major gastrointestinal surgery Open
Aim Gastrointestinal surgeons face an increasingly complex patient population. Patients are older, often with co-morbidities, frailty, nutritional, functional, and cognitive impairments. The aim of this study was to compare functional outc…
View article: Reduction in radioactivity-induced backgrounds using a novel active veto detector for rare event search experiments
Reduction in radioactivity-induced backgrounds using a novel active veto detector for rare event search experiments Open
The results of a newly developed annular cryogenic phonon-mediated active veto detector are discussed which shows a significant reduction of radioactivity-induced backgrounds in rare event search experiments. The veto detector is made up o…
View article: Genetic association study of Alzheimer’s disease through whole genome tiling analysis
Genetic association study of Alzheimer’s disease through whole genome tiling analysis Open
Background Numerous GWAS studies of Alzheimer’s disease (AD) have identified over 70 AD risk variants using SNP‐based genotyping or sequencing data. Recently, a new whole‐genome tiling (WGT) representation of whole‐genome sequencing (WGS) …
View article: DeepCORE: An interpretable multi-view deep neural network model to detect co-operative regulatory elements
DeepCORE: An interpretable multi-view deep neural network model to detect co-operative regulatory elements Open
Gene transcription is an essential process involved in all aspects of cellular functions with significant impact on biological traits and diseases. This process is tightly regulated by multiple elements that co-operate to jointly modulate …
View article: High-flow oxygen <i>via</i> oxygenating mouthguard in short upper gastrointestinal endoscopy: A randomised controlled trial
High-flow oxygen <i>via</i> oxygenating mouthguard in short upper gastrointestinal endoscopy: A randomised controlled trial Open
The use of HFMG offers a novel approach to reducing the incidence of hypoxaemia during short upper gastrointestinal endoscopic procedures in low-risk patients undergoing deep sedation.
View article: Analysis of PyroTamer’s Effect on Current Wildfire Situations
Analysis of PyroTamer’s Effect on Current Wildfire Situations Open
Wildfires have been devastating Earth’s lands since its birth, but only recently have the fires become more rampant and increasing in numbers due to poor human decisions and excruciatingly worsening climate crisis. Our protectors, the fire…
View article: Spontaneous resolution of superficial temporal artery pseudoaneurysm
Spontaneous resolution of superficial temporal artery pseudoaneurysm Open
Superficial temporal artery (STA) pseudoaneurysms are rare vascular lesions that typically present after traumatic head injury. Currently, surgery is the recommended treatment as spontaneous resolution has not been previously reported. Our…
View article: Acute Hernia Repair
Acute Hernia Repair Open
Hernia repair is a common component of the general surgery curriculum, and with good reason.Surgeons will be aware that acute presentations of hernia account for a significant proportion of emergency work.With challenges in accessing routi…
View article: Retracted: PTEN loss drives resistance to the neddylation inhibitor MLN4924 in glioblastoma and can be overcome with TOP2A inhibitors
Retracted: PTEN loss drives resistance to the neddylation inhibitor MLN4924 in glioblastoma and can be overcome with TOP2A inhibitors Open
We show that PTEN status serves as both a novel biomarker for MLN4924 response in GBM and reveals a vulnerability to TOP2A inhibitors in combination with MLN4924.
View article: A Search for Low-mass Dark Matter via Bremsstrahlung Radiation and the Migdal Effect in SuperCDMS
A Search for Low-mass Dark Matter via Bremsstrahlung Radiation and the Migdal Effect in SuperCDMS Open
In this paper, we present a re-analysis of SuperCDMS data using a profile likelihood approach to search for sub-GeV dark matter particles (DM) through two inelastic scattering channels: bremsstrahlung radiation and the Migdal effect. By co…
View article: Saline-polyethylene glycol blends preserve in vitro annulus fibrosus hydration and mechanics: An experimental and finite-element analysis
Saline-polyethylene glycol blends preserve in vitro annulus fibrosus hydration and mechanics: An experimental and finite-element analysis Open
Precise control of tissue water content is essential for ensuring accurate, repeatable, and physiologically relevant measurements of tissue mechanics and biochemical composition. While previous studies have found that saline and polyethyle…
View article: P032 SURGICAL SITE INFECTIONS FOLLOWING EMERGENCY HERNIA REPAIR: A SUB-STUDY FROM THE MASH PROJECT
P032 SURGICAL SITE INFECTIONS FOLLOWING EMERGENCY HERNIA REPAIR: A SUB-STUDY FROM THE MASH PROJECT Open
Aim Acutely symptomatic hernia (ASH) of the abdominal wall and groin are common presentations. Decisions related to repair technique can be driven by contamination and surgical site infection (SSI) risk. The aim of this study is to report …
View article: O35 WHAT HAPPENS TO PATIENTS WITH ACUTELY SYMPTOMATIC HERNIA IN THE UK? FINDINGS FROM THE MASH STUDY
O35 WHAT HAPPENS TO PATIENTS WITH ACUTELY SYMPTOMATIC HERNIA IN THE UK? FINDINGS FROM THE MASH STUDY Open
Aim Acutely symptomatic abdominal wall and groin hernias (ASH) are a common reason for acute surgical admissions in the UK. There is limited data to guide the treatment of such presentations. This study aimed to assess outcomes of emergenc…