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View article: Structural characterization and inhibition of carbonic anhydrase from Candida parapsilosis
Structural characterization and inhibition of carbonic anhydrase from Candida parapsilosis Open
Fungal carbonic anhydrases (CAs) are metalloenzymes that catalyze the reversible hydration of carbon dioxide and play an essential role in fungal adaptation to environments with fluctuating CO2 concentrations. The opportunistic pathogen Ca…
View article: Conformational landscape of the mycobacterial inosine 5′-monophosphate dehydrogenase octamerization interface
Conformational landscape of the mycobacterial inosine 5′-monophosphate dehydrogenase octamerization interface Open
Inosine 5'-monophosphate dehydrogenase (IMPDH), a key enzyme in bacterial purine metabolism, plays an essential role in the biosynthesis of guanine nucleotides and shows promise as a target for antimicrobial drug development. Despite its s…
View article: Deciphering the Allosteric Regulation of Mycobacterial Inosine-5′-Monophosphate Dehydrogenase
Deciphering the Allosteric Regulation of Mycobacterial Inosine-5′-Monophosphate Dehydrogenase Open
Allosteric regulation of inosine 5′-monophosphate dehydrogenase (IMPDH), an essential enzyme of purine metabolism, contributes to the homeostasis of adenine and guanine nucleotides. However, the precise molecular mechanism of IMPDH regulat…
View article: The structure of DarB in complex with Rel <sup>NTD</sup> reveals nonribosomal activation of Rel stringent factors
The structure of DarB in complex with Rel <sup>NTD</sup> reveals nonribosomal activation of Rel stringent factors Open
Rel stringent factors are bifunctional ribosome-associated enzymes that catalyze both synthesis and hydrolysis of the alarmones (p)ppGpp. Besides the allosteric control by starved ribosomes and (p)ppGpp, Rel is regulated by various protein…
View article: Structural basis for HflXr-mediated antibiotic resistance in <i>Listeria monocytogenes</i>
Structural basis for HflXr-mediated antibiotic resistance in <i>Listeria monocytogenes</i> Open
HflX is a ubiquitous bacterial GTPase that splits and recycles stressed ribosomes. In addition to HflX, Listeria monocytogenes contains a second HflX homolog, HflXr. Unlike HflX, HflXr confers resistance to macrolide and lincosamide antibi…
View article: RelA-SpoT Homologue toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis
RelA-SpoT Homologue toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis Open
Summary RelA-SpoT Homolog (RSH) enzymes control bacterial physiology through synthesis and degradation of the nucleotide alarmone (p)ppGpp. We recently discovered multiple families of Small Alarmone Synthetase (SAS) RSH acting as toxins of…