Onur Eskiocak
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View article: Anti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness
Anti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness Open
Intestinal stem cells (ISCs) drive the rapid regeneration of the gut epithelium. However, during aging, their regenerative capacity wanes, possibly through senescence and chronic inflammation, albeit little is known about how aging-associa…
View article: Niche-driven phenotypic plasticity and cis-regulatory dynamics of a revised model for intestinal secretory differentiation
Niche-driven phenotypic plasticity and cis-regulatory dynamics of a revised model for intestinal secretory differentiation Open
Enterocytes and four secretory cell types derive from stem cells located in intestinal crypts. Whereas secretory goblet and Paneth cells have long been considered distinct, we find high overlap in their transcripts and sites of accessible …
View article: Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness
Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness Open
SUMMARY Intestinal stem cells (ISCs) drive the rapid regeneration of the gut epithelium to maintain organismal homeostasis. Aging, however, significantly reduces intestinal regenerative capacity. While cellular senescence is a key feature …
View article: Epigenetic mechanisms of epithelial – immune interactions that shape immune surveillance in the intestinal epithelium
Epigenetic mechanisms of epithelial – immune interactions that shape immune surveillance in the intestinal epithelium Open
Immune surveillance of the intestinal epithelium is regulated by the reciprocal interactions between intestinal epithelial cells, immune system and microbiome. This highly specialized compartment maintains the tolerance against dietary pro…
View article: EXCESS DIETARY SUGAR ALTERS COLONOCYTE METABOLISM AND IMPAIRS THE EARLY PROLIFERATIVE RESPONSE TO DAMAGE
EXCESS DIETARY SUGAR ALTERS COLONOCYTE METABOLISM AND IMPAIRS THE EARLY PROLIFERATIVE RESPONSE TO DAMAGE Open
The colonic epithelium requires continuous renewal by crypt resident intestinal stem cells (ISCs) and transit amplifying (TA) cells to maintain barrier integrity, especially after inflammatory damage. An important regulator of ISC and TA c…
View article: <scp>CRISPR</scp> ‐induced exon skipping of β‐catenin reveals tumorigenic mutants driving distinct subtypes of liver cancer
<span>CRISPR</span> ‐induced exon skipping of β‐catenin reveals tumorigenic mutants driving distinct subtypes of liver cancer Open
CRISPR/Cas9‐driven cancer modeling studies are based on the disruption of tumor suppressor genes by small insertions or deletions (indels) that lead to frame‐shift mutations. In addition, CRISPR/Cas9 is widely used to define the significan…
View article: Excess Dietary Sugar Alters Colonocyte Metabolism and Impairs the Proliferative Response to Damage
Excess Dietary Sugar Alters Colonocyte Metabolism and Impairs the Proliferative Response to Damage Open
View article: Correction: γδ T cell IFNγ production is directly subverted by Yersinia pseudotuberculosis outer protein YopJ in mice and humans
Correction: γδ T cell IFNγ production is directly subverted by Yersinia pseudotuberculosis outer protein YopJ in mice and humans Open
[This corrects the article DOI: 10.1371/journal.ppat.1010103.].
View article: β-Hydroxybutyrate suppresses colorectal cancer
β-Hydroxybutyrate suppresses colorectal cancer Open
View article: IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment
IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment Open
View article: γδ T cell IFNγ production is directly subverted by Yersinia pseudotuberculosis outer protein YopJ in mice and humans
γδ T cell IFNγ production is directly subverted by Yersinia pseudotuberculosis outer protein YopJ in mice and humans Open
Yersinia pseudotuberculosis is a foodborne pathogen that subverts immune function by translocation of Yersinia outer protein (Yop) effectors into host cells. As adaptive γδ T cells protect the intestinal mucosa from pathogen invasion, we a…
View article: γδ T cell IFNγ production is directly subverted by Yersinia pseudotuberculosis outer protein YopJ in mice and humans
γδ T cell IFNγ production is directly subverted by Yersinia pseudotuberculosis outer protein YopJ in mice and humans Open
Yersinia pseudotuberculosis is a foodborne pathogen that subverts immune function by translocation of Yersinia outer protein (Yop) effectors into host cells. As adaptive γδ T cells protect the intestinal mucosa from pathogen invasion, we a…
View article: Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis
Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis Open
Little is known about how interactions of diet, intestinal stem cells (ISCs), and immune cells affect early-stage intestinal tumorigenesis. We show that a high-fat diet (HFD) reduces the expression of the major histocompatibility complex c…
View article: Excess dietary sugar impairs colonic epithelial regeneration in response to damage
Excess dietary sugar impairs colonic epithelial regeneration in response to damage Open
The colonic epithelium requires continuous renewal by intestinal stem cells (ISCs) to restore the barrier after damage and proliferation of epithelial cells is modulated by dietary metabolites. We demonstrate that mice fed a high sugar die…
View article: IL-22 receptor signaling in Paneth cells is critical for their maturation, microbiota colonization, Th17-related immune responses, and anti-Salmonella immunity
IL-22 receptor signaling in Paneth cells is critical for their maturation, microbiota colonization, Th17-related immune responses, and anti-Salmonella immunity Open
Interleukin-22 (IL-22) signaling in the intestines is critical for promoting tissue-protective functions. However, since a diverse array of cell types (absorptive and secretory epithelium as well as stem cells) express IL-22Ra1, a receptor…
View article: Dietary suppression of MHC-II expression in intestinal stem cells enhances intestinal tumorigenesis
Dietary suppression of MHC-II expression in intestinal stem cells enhances intestinal tumorigenesis Open
Little is known about how interactions between diet, immune recognition, and intestinal stem cells (ISCs) impact the early steps of intestinal tumorigenesis. Here, we show that a high fat diet (HFD) reduces the expression of the major hist…