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View article: Plasmid dynamics driving carbapenemase gene dissemination in healthcare environments: a nationwide analysis of closed Enterobacterales genomes
Plasmid dynamics driving carbapenemase gene dissemination in healthcare environments: a nationwide analysis of closed Enterobacterales genomes Open
Plasmid-mediated transmission can account for half of carbapenem-producing Enterobacterales (CPE) dissemination, underscoring the need to identify genetic determinants of plasmid persistence in the hospital setting. From 1,088 CPE isolates…
View article: Protein Malnutrition Facilitates Intestinal Colonization with Highly Resistant <i>Klebsiella pneumoniae</i>
Protein Malnutrition Facilitates Intestinal Colonization with Highly Resistant <i>Klebsiella pneumoniae</i> Open
Pediatric infections with Highly Resistant Enterobacterales (HRE), including Klebsiella pneumoniae resistant to 3 rd -generation cephalosporins and/or carbapenems, disproportionately affect low- and middle-income countries where malnutriti…
View article: Head-to-head comparison of culture-based and direct-from-specimen molecular testing for carbapenemase-producing Gram-negative bacilli: a year-long comparative study in a moderate-prevalence setting
Head-to-head comparison of culture-based and direct-from-specimen molecular testing for carbapenemase-producing Gram-negative bacilli: a year-long comparative study in a moderate-prevalence setting Open
Objectives: An efficient testing and isolation strategy is essential to contain the spread of carbapenemase-producing gram-negative bacilli (CPGNB). We compared the performance of a culture-based strategy utilising chromID CARBA SMART agar…
View article: Impact of standard precautions and unrestricted movements of carbapenemase-producing Enterobacterales (CPE) carriers on CPE transmission in a nursing home in Singapore: a prospective cohort study
Impact of standard precautions and unrestricted movements of carbapenemase-producing Enterobacterales (CPE) carriers on CPE transmission in a nursing home in Singapore: a prospective cohort study Open
Background In 2018, Singapore’s National Infection Prevention & Control Committee (NIPC) recommended standard precautions and unrestricted movements for CPE carriers in nursing homes. Objective This study investigates the short-term impact…
View article: Plastic Waste and COVID-19 Incidence Among Hospital Staff After Deescalation in PPE Use
Plastic Waste and COVID-19 Incidence Among Hospital Staff After Deescalation in PPE Use Open
Importance In September 2023, the Singapore Ministry of Health revised the national personal protective equipment (PPE) guideline for health care personnel (HCP) attending to suspected or confirmed patients with COVID-19, recommending the …
View article: 315. Modeling Strain-Dependent Variability in Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Colonization in the Malnourished Host
315. Modeling Strain-Dependent Variability in Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Colonization in the Malnourished Host Open
Background Particular strains of Carbapenem-resistant Klebsiella pneumoniae (CR-Kp) have achieved global dominance extending to developing countries where malnutrition is a potential risk factor for infection. Bacteria and host properties …
View article: 99. Impact of Covid-19, Divergent Genomic Modes of Transmission and Strain Replacement of Carbapenem-Resistant Organisms in a Single Hospital in Singapore over 12 years
99. Impact of Covid-19, Divergent Genomic Modes of Transmission and Strain Replacement of Carbapenem-Resistant Organisms in a Single Hospital in Singapore over 12 years Open
Background Much remains unknown about the different genomic characteristics of transmission comparing Carbapenem-Resistant Enterobacterales (CREs), Carbapenem-Resistant A. baumannii (CRAB) and Carbapenem-Resistant P. aeruginosa (CRPA). In …
View article: Evaluation of the Xpert Carba-R assay for quantifying carbapenemase-producing bacterial load in stool samples
Evaluation of the Xpert Carba-R assay for quantifying carbapenemase-producing bacterial load in stool samples Open
Background The spread of Carbapenemase-producing Organisms (CPO) remains a major threat globally. Within clinical settings, the existing method of determining gene load involves traditional culture to determine bacterial load and polymeras…
View article: Risk factors for toxoplasmosis in people living with HIV in the Asia-Pacific region
Risk factors for toxoplasmosis in people living with HIV in the Asia-Pacific region Open
Introduction Toxoplasma gondii can cause symptomatic toxoplasmosis in immunodeficient hosts, including in people living with human immunodeficiency virus (PLWH), mainly because of the reactivation of latent infection. We assessed the preva…
View article: Evaluation of NG-Test CARBA 5 version 2, Cepheid Xpert Carba-R, and carbapenem inactivation methods in comparison to whole-genome sequencing for the identification of carbapenemases in non-fermenting Gram-negative bacilli
Evaluation of NG-Test CARBA 5 version 2, Cepheid Xpert Carba-R, and carbapenem inactivation methods in comparison to whole-genome sequencing for the identification of carbapenemases in non-fermenting Gram-negative bacilli Open
NG-Test CARBA 5 (NG-Biotech) is a rapid in vitro multiplex immunoassay for the phenotypic detection and differentiation of the “big five” carbapenemase families (KPC, OXA-48-like, VIM, IMP, and NDM). Version 2 of this assay was evaluated a…
View article: ACORN (A Clinically-Oriented Antimicrobial Resistance Surveillance Network) II: protocol for case based antimicrobial resistance surveillance
ACORN (A Clinically-Oriented Antimicrobial Resistance Surveillance Network) II: protocol for case based antimicrobial resistance surveillance Open
Background : Antimicrobial resistance surveillance is essential for empiric antibiotic prescribing, infection prevention and control policies and to drive novel antibiotic discovery. However, most existing surveillance systems are isolat…
View article: PSEUDOMONAS AERUGINOSA – A HIDDEN RESERVOIR OF CARBAPENEMASE-PRODUCING (CP) GENES
PSEUDOMONAS AERUGINOSA – A HIDDEN RESERVOIR OF CARBAPENEMASE-PRODUCING (CP) GENES Open
Intro: Patients who are at risk of carriage of carbapenem-producing Gram negative bacteria(CPGNB) are screened upon hospitalization as part of infection control and prevention (IPC) strategy. However, non-fermenters such as Pseudomonas aer…
View article: Dissemination of <i>Pseudomonas aeruginosa bla</i> <sub>NDM-1</sub> -Positive ST308 Clone in Singapore
Dissemination of <i>Pseudomonas aeruginosa bla</i> <sub>NDM-1</sub> -Positive ST308 Clone in Singapore Open
P. aeruginosa is a Gram-negative opportunistic pathogen ubiquitously found in the environment and a major cause of nosocomial infections. While the P. aeruginosa ST308 clone has been known to bear bla IMP and bla VIM among global isolates,…
View article: Erratum to “Impact of delta variant and vaccination on SARS-CoV-2 secondary attack rate among household close contacts” [The Lancet Regional Health – Western Pacific 17 (2021) 100299]
Erratum to “Impact of delta variant and vaccination on SARS-CoV-2 secondary attack rate among household close contacts” [The Lancet Regional Health – Western Pacific 17 (2021) 100299] Open
[This corrects the article DOI: 10.1016/j.lanwpc.2021.100299.].
View article: SG-APSIC1097: The impact of COVID-19 on the incidence of carbapenem-resistant Enterobacterales (CRE) in Singapore: An interrupted time-series analysis
SG-APSIC1097: The impact of COVID-19 on the incidence of carbapenem-resistant Enterobacterales (CRE) in Singapore: An interrupted time-series analysis Open
Objectives: Over the past 2 years, many infection prevention and control (IPC) resources have been diverted to manage the COVID-19 pandemic. Its impact on the incidence of antimicrobial-resistant organisms has not been adequately studied. …
View article: SG-APSIC1123: Diagnostic and infection prevention and control (IPC) performance of rapid polymerase chain reaction (PCR) compared to conventional culture PCR methods for detecting carbapenemase-producing organisms (CPOs)
SG-APSIC1123: Diagnostic and infection prevention and control (IPC) performance of rapid polymerase chain reaction (PCR) compared to conventional culture PCR methods for detecting carbapenemase-producing organisms (CPOs) Open
Objectives: In this study, we compared the performance of a rapid polymerase chain reaction (PCR) method in detecting carbapenemase-producing organisms (CPOs) and its impact on infection prevention and control (IPC) measures compared with …
View article: SG-APSIC1118: Introduction of carbapenemase-producing Enterobacterales (CPE) in the aqueous environment of the newly built National Centre for Infectious Diseases (NCID) in Singapore
SG-APSIC1118: Introduction of carbapenemase-producing Enterobacterales (CPE) in the aqueous environment of the newly built National Centre for Infectious Diseases (NCID) in Singapore Open
Objectives: In healthcare facilities, environmental reservoirs of CPE are associated with CPE outbreaks. In the newly built NCID building, we studied the introduction of CPE in the aqueous environment. Methods: We sampled the aqueous envir…
View article: SG-APSIC1095: Acquisition rate of carbapenemase-producing organisms (CPOs) among hospital contacts of CPO patients: An interim subgroup analysis of a cohort study
SG-APSIC1095: Acquisition rate of carbapenemase-producing organisms (CPOs) among hospital contacts of CPO patients: An interim subgroup analysis of a cohort study Open
Objectives: The increase in carbapenemase-producing organism (CPO) transmission among hospitalized patients is a growing concern. Studies investigating the transmission of CPO to epidemiologically linked contacts are scarce. We conducted a…
View article: Whole-genome sequencing to uncover sources of carbapenemase gene transmission evading standard-of-care infection prevention measures
Whole-genome sequencing to uncover sources of carbapenemase gene transmission evading standard-of-care infection prevention measures Open
Carbapenemase-producing Enterobacterales (CPE), with extremely limited safe treatment options, are an increasing threat to human health related to rapid international spread and increased morbidity and mortality. Whole-genome sequencing ha…
View article: Impact of COVID-19 pandemic on carbapenem-resistant Enterobacterales incidence in the South-East Asia region: an observational study
Impact of COVID-19 pandemic on carbapenem-resistant Enterobacterales incidence in the South-East Asia region: an observational study Open
The COVID-19 pandemic led to an initial increase in the incidence of carbapenem-resistant Enterobacterales (CRE) from clinical cultures in South-East Asia hospitals, which was unsustained as the pandemic progressed. Conversely, there was a…
View article: Residual Humoral Immunity Sustained Over Decades in a Cohort of Vaccinia-Vaccinated Individuals
Residual Humoral Immunity Sustained Over Decades in a Cohort of Vaccinia-Vaccinated Individuals Open
Serological testing of Singaporeans who received childhood smallpox vaccination found anti-vaccinia IgG binding and neutralizing activity indicating long-term humoral immunity. There was correlation between IgG and neutralizing titers indi…
View article: Viable Monkeypox virus in the environment of a patient room
Viable Monkeypox virus in the environment of a patient room Open
We conducted a prospective environmental surveillance study to investigate the air, surface, dust and water contamination of a room occupied by a patient infected with Monkeypox virus (MPXV) at various stages of his illness. The patient te…
View article: Analysis of COVID-19 Incidence and Severity Among Adults Vaccinated With 2-Dose mRNA COVID-19 or Inactivated SARS-CoV-2 Vaccines With and Without Boosters in Singapore
Analysis of COVID-19 Incidence and Severity Among Adults Vaccinated With 2-Dose mRNA COVID-19 or Inactivated SARS-CoV-2 Vaccines With and Without Boosters in Singapore Open
Importance Assessing booster effectiveness of COVID-19 mRNA vaccine and inactivated SARS-CoV-2 vaccine over longer time intervals and in response to any further SARS-CoV-2 variants is crucial in determining optimal COVID-19 vaccination str…