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View article: Immune aging impairs muscle regeneration via macrophage-derived anti-oxidant selenoprotein P
Immune aging impairs muscle regeneration via macrophage-derived anti-oxidant selenoprotein P Open
Muscle regeneration is impaired with aging, due to both intrinsic defects of muscle stem cells (MuSCs) and alterations of their niche. Here, we monitor the cells constituting the MuSC niche over time in young and old regenerating mouse mus…
View article: Integrating<i>in silico</i>predictions with an engineered tissue assay identifies Perlecan as an age-perturbed re-quiescence cue for muscle stem cells
Integrating<i>in silico</i>predictions with an engineered tissue assay identifies Perlecan as an age-perturbed re-quiescence cue for muscle stem cells Open
Skeletal muscle regeneration is mediated by resident muscle stem cells that produce progeny to repair or recreate muscle. Critical to this function is the ability to transition between states of proliferation and quiescence. This balancing…