Explanipedia

Editorial: Role of extracellular vesicles in promoting cancer stem cell properties, tumor aggressiveness and metastasis formation in solid tumors Open

Giulia Bertolini, Orazio Fortunato, Serena Lucotti · 2024

Enhancing neovascularization post-myocardial infarction through injectable hydrogel functionalized with endothelial-derived EVs Open

Fabio Maiullari, Marika Milan, Maila Chirivì, Maria Grazia Ceraolo, Salma Bousselmi , et al. · 2024

Over the past three decades, cell therapy development has fallen short of expectations, with many cellular sources demonstrating a ‘Janus effect’ and raising safety concerns. Extracellular vesicles (EVs), supported by advanced technologies…

Extracellular vesicles from subjects with COPD modulate cancer initiating cells phenotype through HIF-1α shuttling Open

Ilaria Petraroia, Patrizia Ghidotti, Giulia Bertolini, Francesca Pontis, Luca Roz , et al. · 2023

The metastatic niche formation: focus on extracellular vesicle-mediated dialogue between lung cancer cells and the microenvironment Open

Francesca Pontis, Luca Roz, Orazio Fortunato, Giulia Bertolini · 2023

Lung cancer is the deadliest cancer in the world, with the majority of patients presenting with advanced or metastatic disease at first diagnosis. The lungs are also one of the most common sites of metastasis from lung cancer and other tum…

Immunomodulatory role of EV-derived non-coding RNA in lung cancer Open

Patrizia Ghidotti, Ilaria Petraroia, Orazio Fortunato, Francesca Pontis · 2023

Lung cancer is the deadliest cancer worldwide, primarily because of its metastatic spread. Extracellular vesicles (EVs) are small lipid-bilayer particles released by almost all types of cells. EVs play fundamental roles in cell-cell commun…

MiR-223 Exclusively Impairs In Vitro Tumor Growth through IGF1R Modulation in Rhabdomyosarcoma of Adolescents and Young Adults Open

Michela Casanova, Francesca Pontis, Patrizia Ghidotti, Ilaria Petraroia, Lara Veronica Venturini , et al. · 2022

Adolescents and young adults (AYA) with rhabdomyosarcoma (RMS) form a subgroup of patients whose optimal clinical management and best possible access to care remain a challenge and whose survival rates lag behind that of children diagnosed…

Results of a prospective observational study of autologous peripheral blood mononuclear cell therapy for no-option critical limb-threatening ischemia and severe diabetic foot ulcers Open

Andrea Panunzi, Fabiana Madotto, Elena Sangalli, Federica Riccio, Adriana Sganzaroli , et al. · 2022

Circulating CD81-expressing extracellular vesicles as biomarkers of response for immune-checkpoint inhibitors in advanced NSCLC Open

Diego Signorelli, Patrizia Ghidotti, Claudia Proto, Marta Brambilla, Alessandro De Toma , et al. · 2022

PD-L1 in tumor cells is the only used biomarker for anti PD1/PD-L1 immune-checkpoints inhibitors (ICI) in Non Small Cell Lung Cancer (NSCLC) patients. However, this parameter is inaccurate to predict response, especially in patients with l…

Development of a Molecular Blood-Based Immune Signature Classifier as Biomarker for Risks Assessment in Lung Cancer Screening Open

Orazio Fortunato, Veronica Huber, Miriam Segale, Agata Cova, Viviana Vallacchi , et al. · 2022

Background: Low-dose CT (LDCT) screening trials have shown that lung cancer early detection saves lives. However, a better stratification of the screening population is still needed. In this respect, we generated and prospectively validate…

Human platelet lysate‐derived extracellular vesicles enhance angiogenesis through <span>miR</span> ‐126 Open

Antonella Bordin, Maila Chirivì, Francesca Pagano, Marika Milan, Marco Iuliano , et al. · 2022

Objectives Extracellular vesicles (EVs) are key biological mediators of several physiological functions within the cell microenvironment. Platelets are the most abundant source of EVs in the blood. Similarly, platelet lysate (PL), the best…

“Human platelet lysate derived extracellular vesicles enhance angiogenesis through miR-126” Open

Antonella Bordin, Maila Chirivì, Francesca Pagano, Marika Milan, Marco Iuliano , et al. · 2022

Objectives extracellular vesicles (EVs) are key biological mediators of several physiological functions within the cell microenvironment. Platelets are the most abundant source of EVs in the blood. Similarly, platelet lysate (PL), the best…

MiR-486-5p Targets CD133+ Lung Cancer Stem Cells through the p85/AKT Pathway Open

Massimo Moro, Orazio Fortunato, Giulia Bertolini, Mavis Mensah, Cristina Borzi , et al. · 2022

Despite improvements in therapies and screening strategies, lung cancer prognosis still remains dismal, especially for metastatic tumors. Cancer stem cells (CSCs) are endowed with properties such as chemoresistance, dissemination, and stem…

Single-Cell Phenotypic and Molecular Characterization of Circulating Tumor Cells Isolated from Cryopreserved Peripheral Blood Mononuclear Cells of Patients with Lung Cancer and Sarcoma Open

Marta Vismara, Carolina Reduzzi, Marco Silvestri, Fabio Murianni, Giuseppe Lo Russo , et al. · 2022

Background The isolation of circulating tumor cells (CTCs) requires rapid processing of the collected blood due to their inherent fragility. The ability to recover CTCs from peripheral blood mononuclear cells (PBMCs) preserved from cancer …

Circulating extracellular vesicles from individuals at high-risk of lung cancer induce pro-tumorigenic conversion of stromal cells through transfer of miR-126 and miR-320 Open

Francesca Pontis, Luca Roz, Mavis Mensah, Miriam Segale, Massimo Moro , et al. · 2021

Background Extracellular vesicles (EVs) containing specific subsets of functional biomolecules are released by all cell types and analysis of circulating EVs can provide diagnostic and prognostic information. To date, little is known regar…

Cotargeting of miR‐126‐3p and miR‐221‐3p inhibits PIK3R2 and PTEN, reducing lung cancer growth and metastasis by blocking AKT and CXCR4 signalling Open

Daniela Di Paolo, Francesca Pontis, Massimo Moro, Giovanni Centonze, Giulia Bertolini , et al. · 2021

Lung cancer is the leading cause of cancer‐related death worldwide. Late diagnosis and metastatic dissemination contribute to its low survival rate. Since microRNA (miRNA) deregulation triggers lung carcinogenesis, miRNAs might represent a…

A novel CXCR4 antagonist counteracts paradoxical generation of cisplatin-induced pro-metastatic niches in lung cancer Open

Giulia Bertolini, Valeria Cancila, Massimo Milione, Giuseppe Lo Russo, Orazio Fortunato , et al. · 2021

Platinum-based chemotherapy remains widely used in advanced non-small cell lung cancer (NSCLC) despite experimental evidence of its potential to induce long-term detrimental effects, including the promotion of pro-metastatic microenvironme…

Author response for "Co‐targeting of miR‐126‐3p and miR‐221‐3p inhibits PIK3R2 and PTEN, reducing lung cancer growth and metastasis by blocking AKT and CXCR4 signaling" Open

Daniela Di Paolo, Francesca Pontis, Massimo Moro, Giovanni Centonze, Giulia Bertolini , et al. · 2021

In vivo organized neovascularization induced by 3D bioprinted endothelial-derived extracellular vesicles Open

Fabio Maiullari, Maila Chirivì, Marco Costantini, Anna Maria Ferretti, Sandro Recchia , et al. · 2021

Extracellular vesicles (EVs) have become a key tool in the biotechnological landscape due to their well-documented ability to mediate intercellular communication. This feature has been explored and is under constant investigation by resear…

The Therapeutic Potential of MicroRNAs in Cancer: Illusion or Opportunity? Open

Orazio Fortunato, Marilena V. Iorio · 2020

The functional involvement of microRNAs in human neoplasia has raised in the last years an increasing interest in the scientific community toward the potential application in clinics as therapeutic tools. Indeed, the possibility to modulat…

SDF-1/CXCR4 inhibition prevents paradoxical generation of cisplatin-induced pro-metastatic niches Open

Giulia Bertolini, Valeria Cancila, Massimo Milione, Giuseppe Lo Russo, Orazio Fortunato , et al. · 2020

Platinum-based chemotherapy remains widely used in advanced non-small cell lung cancer (NSCLC) despite its ineffectiveness in long-term control of metastasis. Here, we uncover the interconnected pathways subtending cisplatin-induced metast…

CXCR4 Inhibition Counteracts Immunosuppressive Properties of Metastatic NSCLC Stem Cells Open

Orazio Fortunato, Dimas Carolina Belisario, Mara Compagno, Francesca Giovinazzo, Cristiano Bracci , et al. · 2020

Cancer stem cells (CSCs) are functionally defined as the cell subset with greater potential to initiate and propagate tumors. Within the heterogeneous population of lung CSCs, we previously identified highly disseminating CD133+CXCR4+ cell…

Anticancer innovative therapy: Highlights from the ninth annual meeting Open

Tatiana Volpari, Francesca De Santis, Adrian P. Bracken, Serenella M. Pupa, Marcus Buschbeck , et al. · 2019

MiRNAs as Players in Rhabdomyosarcoma Development Open

Patrizia Gasparini, Andrea Ferrari, Michela Casanova, Francesca Limido, Maura Massimino , et al. · 2019

Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma of childhood and adolescence, is a rare but aggressive malignancy that originates from immature mesenchymal cells committed to skeletal muscle differentiation. Although RMS is, ge…

c-Myc shuttled by tumour-derived extracellular vesicles promotes lung bronchial cell proliferation through miR-19b and miR-92a Open

Cristina Borzi, Linda Calzolari, Anna Maria Ferretti, Laura Caleca, Ugo Pastorino , et al. · 2019

MA13.09 Cisplatin Sustains Lung Cancer Metastasis Through the Systemic Activation of SDF-1/CXCR4 Axis Open

Giulia Bertolini, Valeria Cancila, Claudio Tripodo, Gabriella Sozzi, Giuseppe Lo Russo , et al. · 2019

Age-Related Alterations in Immune Contexture Are Associated with Aggressiveness in Rhabdomyosarcoma Open

Patrizia Gasparini, Orazio Fortunato, Loris De Cecco, Michela Casanova, Maria Federica Iannò , et al. · 2019

Adolescents and young adults (AYA) with rhabdomyosarcoma (RMS) form a subgroup of patients whose optimal clinical management and access to care remain a challenge and whose survival lacks behind that of children diagnosed with histological…

Coated cationic lipid-nanoparticles entrapping miR-660 inhibit tumor growth in patient-derived xenografts lung cancer models Open

Massimo Moro, Daniela Di Paolo, Massimo Milione, Giovanni Centonze, Viviana Bornaghi , et al. · 2019

Exo-miRNAs as a New Tool for Liquid Biopsy in Lung Cancer Open

Orazio Fortunato, Patrizia Gasparini, Mattia Boeri, Gabriella Sozzi · 2019

Lung cancer is the predominant cause of cancer-related deaths. The high mortality rates are mainly due to the lack of diagnosis before the cancer is at a late stage. Liquid biopsy is a promising technique that could allow early diagnosis o…

Circulating mir‐320a promotes immunosuppressive macrophages M2 phenotype associated with lung cancer risk Open

Orazio Fortunato, Cristina Borzi, Massimo Milione, Giovanni Centonze, Davide Conte , et al. · 2018

miRNAs play a central role in the complex signaling network of cancer cells with the tumor microenvironment. Little is known on the origin of circulating miRNAs and their relationship with the tumor microenvironment in lung cancer. Here, w…

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening Open

Mavis Mensah, Cristina Borzi, Carla Verri, Paola Suatoni, Davide Conte , et al. · 2017

The development of a minimally invasive test, such as liquid biopsy, for early lung cancer detection in its preclinical phase is crucial to improve the outcome of this deadly disease. MicroRNAs (miRNAs) are tissue specific, small, non-codi…

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