Explanipedia

KIF5A binds RNA to orchestrate synaptic mRNA localization and stress granules in ALS Open

Phuong Le, Neeraj Lal, Shuhao Xu, Sara Mumford, Megan Huang , et al. · 2025

Neuronal health depends on the precise transport and local translation of mRNAs to maintain synaptic function across highly polarized cellular architecture. While kinesin motor proteins are known to mediate mRNA transport, the specificity …

RNA triggers chronic stress during neuronal aging Open

Kevin Rhine, Edward Epstein, Natasha M. Carlson, Xiaoqin Ge, Orel Mizrahi , et al. · 2025

Neurodegenerative diseases are linked with dysregulation of the integrated stress response (ISR), which coordinates cellular homeostasis during and after stress events. Cellular stress can arise from several sources, but there is significa…

Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress Open

Kevin Rhine, Rachel Li, Hema Kopalle, Katherine Rothamel, Xiaoqin Ge , et al. · 2025

Aging is one of the most prominent risk factors for neurodegeneration, yet the molecular mechanisms underlying the deterioration of old neurons are mostly unknown. To efficiently study neurodegeneration in the context of aging, we transdif…

Integrative CRISPR Screens and RNA-Omics Discover an Essential Role for PUF60-3’ Splice Site Interactions in Cancer Progression Open

Alexandra Tankka, Jaclyn M. Einstein, Cindy Ke Zhou, Vivian N. Pham, Yuhan Zhang , et al. · 2025

RNA-binding proteins (RBPs) are important regulators of post-transcriptional gene expression. Understanding which and how RBPs promote cancer progression is crucial for cancers that lack effective targeted therapies such as triple negative…

LARP6 regulates the mRNA translation of fibrogenic genes in liver fibrosis Open

Hyun Young Kim, Orel Mizrahi, Wonseok Lee, Sara Brin Rosenthal, Cuijuan Han , et al. · 2025

Summary Metabolic syndrome and excessive alcohol consumption result in liver injury and fibrosis, which is characterized by increased collagen production by activated Hepatic Stellate Cells (HSCs). LARP6, an RNA-binding protein, was shown …

Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes Open

Norah Al-Azzam, Jenny H To, Vaishali Gautam, Lena Annika Street, Chloe Nguyen , et al. · 2024

Amyotrophic lateral sclerosis (ALS) is linked to the reduction of certain nucleoporins in neurons. Increased nuclear localization of charged multivesicular body protein 7 (CHMP7), a protein involved in nuclear pore surveillance, has been i…

Large-scale map of RNA-binding protein interactomes across the mRNA life cycle Open

Lena Annika Street, Katherine Rothamel, Kristopher W. Brannan, Wenhao Jin, Benjamin J. Bokor , et al. · 2024

mRNAs interact with RNA-binding proteins (RBPs) throughout their processing and maturation. While efforts have assigned RBPs to RNA substrates, less exploration has leveraged protein-protein interactions (PPIs) to study proteins in mRNA li…

LARP4 is an RNA-binding protein that binds nuclear-encoded mitochondrial mRNAs to promote mitochondrial function Open

Benjamin M. Lewis, Chae Yun Cho, Hsuan-Lin Her, Orel Mizrahi, Tony Hunter , et al. · 2023

Mitochondria-associated RNA-binding proteins (RBPs) have emerged as key contributors to mitochondrial biogenesis and homeostasis. With few examples known, we set out to identify RBPs that regulate nuclear-encoded mitochondrial mRNAs (NEMmR…

DAP5 drives translation of specific mRNA targets with upstream ORFs in human embryonic stem cells Open

Maya David, Tsviya Olender, Orel Mizrahi, Shira Weingarten-Gabbay, Gilgi Friedlander , et al. · 2022

Death associated protein 5 (DAP5/eIF4G2/NAT1) is a member of the eIF4G translation initiation factors that has been shown to mediate noncanonical and/or cap-independent translation. It is essential for embryonic development and for differe…

Dynamic changes in tRNA modifications and abundance during T cell activation Open

Roni Rak, Michal Polonsky, Inbal Eizenberg-Magar, Yufeng Mo, Yuriko Sakaguchi , et al. · 2021

The tRNA pool determines the efficiency, throughput, and accuracy of translation. Previous studies have identified dynamic changes in the tRNA (transfer RNA) supply and mRNA (messenger RNA) demand during cancerous proliferation. Yet dynami…

SARS-CoV-2 uses a multipronged strategy to impede host protein synthesis Open

Yaara Finkel, Avi Gluck, Aharon Nachshon, Roni Winkler, Tal Fisher , et al. · 2021

Anti-tumour immunity induces aberrant peptide presentation in melanoma Open

Osnat Bartok, Abhijeet Pataskar, Remco Nagel, Maarja Laos, Eden Goldfarb , et al. · 2020

SARS-CoV-2 utilizes a multipronged strategy to suppress host protein synthesis Open

Yaara Finkel, Avi Gluck, Roni Winkler, Aharon Nachshon, Orel Mizrahi , et al. · 2020

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing coronavirus disease 19 (COVID-19) pandemic. Despite the urgent need, we still do not fully understand the molecular basis of SARS-CoV-2 pathogenesis a…

Context-dependent functional compensation between Ythdf m<sup>6</sup>A reader proteins Open

Lior Lasman, Vladislav Krupalnik, Sergey Viukov, Nofar Mor, Alejandro Aguilera-Castrejon , et al. · 2020

The N6-methyladenosine (m 6 A) modification is the most prevalent post-transcriptional mRNA modification, regulating mRNA decay and splicing. It plays a major role during normal development, differentiation, and disease progression. The mo…

The coding capacity of SARS-CoV-2 Open

Yaara Finkel, Orel Mizrahi, Aharon Nachshon, Shira Weingarten-Gabbay, David Morgenstern , et al. · 2020

Context-dependent functional compensation between Ythdf m6A readers Open

Lior Lasman, Vladislav Krupalnik, Shay Geula, Mirie Zerbib, Sergey Viukov , et al. · 2020

The N6-methyladenosine (m 6 A) modification is the most prevalent post-transcriptional mRNA modification, regulating mRNA decay, translation and splicing. It plays a major role during normal development, differentiation, and disease progre…

The coding capacity of SARS-CoV-2 Open

Yaara Finkel, Orel Mizrahi, Aharon Nachshon, Shira Weingarten-Gabbay, David Morgenstern , et al. · 2020

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing Coronavirus disease 19 (COVID-19) pandemic 1,2 . In order to understand SARS-CoV-2 pathogenicity and antigenic potential, and to develop diagnostic an…

Dynamic changes in tRNA modifications and abundance during T-cell activation Open

Roni Rak, Michal Polonsky, Inbal Eizenberg-Magar, Yufeng Mo, Yuriko Sakaguchi , et al. · 2020

The tRNA pool determines the efficiency, throughput, and accuracy of translation. Previous studies have identified dynamic changes in the tRNA supply and mRNA demand during cancerous proliferation. Yet, dynamic changes may occur also durin…

A study of Virus-induced changes in mRNA secondary structure uncover cis-regulatory elements that directly control gene expression. Mizrahi et al. Open

Orel Mizrahi · 2018

Unraveling cis-regulatory elements by mapping changes in mRNA structure for that reason, we measure the changes in mRNA structure using DMS-MaPseq libraries between uninfected and HCMV infected cells, and found dozens of regions in mRNAs t…

RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure Open

Oz Solomon, Ayelet Di Segni, Karen Cesarkas, Hagit T. Porath, Victoria Marcu‐Malina , et al. · 2017

Global mRNA polarization regulates translation efficiency in the intestinal epithelium Open

Andreas E. Moor, Matan Golan, Efi E. Massasa, Doron Lemze, Tomer Weizman , et al. · 2017

Location, location, location The distribution of RNA in cells is important for efficient translation into proteins. Asymmetric RNA localization is known in several cell types but is poorly understood in gut epithelial cells. Moor et al. fo…

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