Ori D. Rotstein
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View article: A Multimodal Evaluation of Transcranial Photobiomodulation in Mild Cognitive Impairment: Cognitive, Metabolic, and Neuroimaging Outcomes of a Pilot Randomized Control Trial
A Multimodal Evaluation of Transcranial Photobiomodulation in Mild Cognitive Impairment: Cognitive, Metabolic, and Neuroimaging Outcomes of a Pilot Randomized Control Trial Open
INTRODUCTION: Mild cognitive impairment (MCI), a prodromal stage of Alzheimer's disease and related dementias (ADRD), offers a critical window for early intervention. Mitochondrial dysfunction is increasingly recognized as a driver of neur…
View article: Phenotypic screening in influenza-infected zebrafish identifies Nrf2-mediated compound protective against ischemia-reperfusion injury
Phenotypic screening in influenza-infected zebrafish identifies Nrf2-mediated compound protective against ischemia-reperfusion injury Open
View article: Predicting mortality risk following major lower extremity amputation using machine learning
Predicting mortality risk following major lower extremity amputation using machine learning Open
View article: Predicting 1-year Successful Clinical Use of an Arteriovenous Access for Hemodialysis Using Machine Learning
Predicting 1-year Successful Clinical Use of an Arteriovenous Access for Hemodialysis Using Machine Learning Open
View article: Using Machine Learning to Predict Outcomes Following Thoracic and Complex Endovascular Aortic Aneurysm Repair
Using Machine Learning to Predict Outcomes Following Thoracic and Complex Endovascular Aortic Aneurysm Repair Open
Background Thoracic endovascular aortic repair (TEVAR) and complex endovascular aneurysm repair (EVAR) are complex procedures that carry a significant risk of complications. While risk prediction tools can aid in clinical decision making, …
View article: Predicting lack of clinical improvement following varicose vein ablation using machine learning
Predicting lack of clinical improvement following varicose vein ablation using machine learning Open
View article: Using Machine Learning to Predict Outcomes Following Transfemoral Carotid Artery Stenting
Using Machine Learning to Predict Outcomes Following Transfemoral Carotid Artery Stenting Open
Background Transfemoral carotid artery stenting (TFCAS) carries important perioperative risks. Outcome prediction tools may help guide clinical decision‐making but remain limited. We developed machine learning algorithms that predict 1‐yea…
View article: Predicting inferior vena cava filter complications using machine learning
Predicting inferior vena cava filter complications using machine learning Open
View article: Comprehensive review of virtual assistants in vascular surgery
Comprehensive review of virtual assistants in vascular surgery Open
Virtual assistants, broadly defined as digital services designed to simulate human conversation and provide personalized responses based on user input, have the potential to improve health care by supporting clinicians and patients in term…
View article: Bridging the gap between in vitro and in vivo models: a way forward to clinical translation of mitochondrial transplantation in acute disease states
Bridging the gap between in vitro and in vivo models: a way forward to clinical translation of mitochondrial transplantation in acute disease states Open
View article: Using Machine Learning to Predict Outcomes Following Carotid Artery Stenting
Using Machine Learning to Predict Outcomes Following Carotid Artery Stenting Open
View article: Machine Learning to Predict Outcomes of Endovascular Intervention for Patients With PAD
Machine Learning to Predict Outcomes of Endovascular Intervention for Patients With PAD Open
Importance Endovascular intervention for peripheral artery disease (PAD) carries nonnegligible perioperative risks; however, outcome prediction tools are limited. Objective To develop machine learning (ML) algorithms that can predict outco…
View article: Restoration of blood vessel regeneration in the era of combination SGLT2i and GLP-1RA therapy for diabetes and obesity
Restoration of blood vessel regeneration in the era of combination SGLT2i and GLP-1RA therapy for diabetes and obesity Open
Ischaemic cardiovascular diseases, including peripheral and coronary artery disease, myocardial infarction, and stroke, remain major comorbidities for individuals with type 2 diabetes (T2D) and obesity. During cardiometabolic chronic disea…
View article: South Asian adults with ASCVD exhibit a reduction in circulating vascular regenerative cell content compared to White European adults: a sub-analysis of the ORIGINS-RCE CardioLink-13 study
South Asian adults with ASCVD exhibit a reduction in circulating vascular regenerative cell content compared to White European adults: a sub-analysis of the ORIGINS-RCE CardioLink-13 study Open
Background Compared to people of other races and ethnicities, South Asian (SA) adults are disproportionately affected by a higher burden of type 2 diabetes (T2D) and atherosclerotic cardiovascular disease (ASCVD). We previously found that …
View article: Inhalation of ACE2 as a therapeutic target on sex-bias differences in SARS-CoV-2 infection and variant of concern
Inhalation of ACE2 as a therapeutic target on sex-bias differences in SARS-CoV-2 infection and variant of concern Open
View article: Effect of remote ischemic conditioning on the immune-inflammatory profile in patients with traumatic hemorrhagic shock in a randomized controlled trial
Effect of remote ischemic conditioning on the immune-inflammatory profile in patients with traumatic hemorrhagic shock in a randomized controlled trial Open
Resuscitation induced ischemia/reperfusion predisposes trauma patients to systemic inflammation and organ dysfunction. We investigated the effect of remote ischemic conditioning (RIC), a treatment shown to prevent ischemia/reperfusion inju…
View article: Augmented Parkin-dependent mitophagy underlies the hepatoprotective effect of remote ischemic conditioning used prior to hemorrhagic shock
Augmented Parkin-dependent mitophagy underlies the hepatoprotective effect of remote ischemic conditioning used prior to hemorrhagic shock Open
RIPC was hepatoprotective in WT mice following HSR but not in parkin-/- mice. Loss of protection in parkin-/- mice corresponded with the failure of RIPC plus HSR to upregulate the mitophagic process. Improving mitocho…
View article: Key Role of Mesenchymal Stromal Cell Interaction with Macrophages in Promoting Repair of Lung Injury
Key Role of Mesenchymal Stromal Cell Interaction with Macrophages in Promoting Repair of Lung Injury Open
Lung macrophages (Mφs) are essential for pulmonary innate immunity and host defense due to their dynamic polarization and phenotype shifts. Mesenchymal stromal cells (MSCs) have secretory, immunomodulatory, and tissue-reparative properties…
View article: SARS-CoV-2 RBD and Its Variants Can Induce Platelet Activation and Clearance: Implications for Antibody Therapy and Vaccinations against COVID-19
SARS-CoV-2 RBD and Its Variants Can Induce Platelet Activation and Clearance: Implications for Antibody Therapy and Vaccinations against COVID-19 Open
The COVID-19 pandemic caused by SARS-CoV-2 virus is an ongoing global health burden. Severe cases of COVID-19 and the rare cases of COVID-19 vaccine-induced-thrombotic-thrombocytopenia (VITT) are both associated with thrombosis and thrombo…
View article: Validating fatty acid binding protein 3 as a diagnostic and prognostic biomarker for peripheral arterial disease: a three-year prospective follow-up study
Validating fatty acid binding protein 3 as a diagnostic and prognostic biomarker for peripheral arterial disease: a three-year prospective follow-up study Open
View article: ACTIVATION OF THE MITOCHONDRIAL ANTIVIRAL SIGNALING PROTEIN (MAVS) FOLLOWING LIVER ISCHEMIA/REPERFUSION AND ITS EFFECT ON INFLAMMATION AND INJURY
ACTIVATION OF THE MITOCHONDRIAL ANTIVIRAL SIGNALING PROTEIN (MAVS) FOLLOWING LIVER ISCHEMIA/REPERFUSION AND ITS EFFECT ON INFLAMMATION AND INJURY Open
Resuscitation of trauma patients after hemorrhagic shock causes global I/R, which may contribute to organ dysfunction. Oxidative stress resulting from I/R is known to induce signaling pathways leading to the production of inflammatory mole…
View article: History of the Department of Surgery at the University of Toronto: celebrating a centennial of progress and innovation
History of the Department of Surgery at the University of Toronto: celebrating a centennial of progress and innovation Open
Now in its centennial year since inauguration, the Department of Surgery at the University of Toronto lays claim to more than 500 faculty, 270 residents, and 250 clinical fellows. There are 7 direct entry residency training programs, and 4…
View article: STOP Signs: A Population-based Interrupted Time Series Analysis of Antibiotic Duration for Complicated Intraabdominal Infection Before and After the Publication of a Landmark RCT
STOP Signs: A Population-based Interrupted Time Series Analysis of Antibiotic Duration for Complicated Intraabdominal Infection Before and After the Publication of a Landmark RCT Open
Objective: To determine if the STOP-IT randomized controlled trial changed antibiotic prescribing in patients with Complicated Intraabdominal Infection (CIAI). Summary of Background Data: CIAI is common and causes significant morbidity. In…
View article: Perceived Challenges to Routine Uptake of the Ankle Brachial Index within Primary Care Practice
Perceived Challenges to Routine Uptake of the Ankle Brachial Index within Primary Care Practice Open
(1) Introduction: The ankle-brachial index (ABI) is the most widely used method of diagnosing peripheral arterial disease (PAD). However, the uptake of ABIs has been reported to be low in primary care settings across different various heal…
View article: Vapourized hydrogen peroxide decontamination in a hospital setting inactivates SARS-CoV-2 and HCoV-229E without compromising filtration efficiency of unexpired N95 respirators
Vapourized hydrogen peroxide decontamination in a hospital setting inactivates SARS-CoV-2 and HCoV-229E without compromising filtration efficiency of unexpired N95 respirators Open
View article: Myeloid Cell Caspase-8 Contributes to Inflammatory Acute Lung Injury in Clinical and Experimental Sepsis
Myeloid Cell Caspase-8 Contributes to Inflammatory Acute Lung Injury in Clinical and Experimental Sepsis Open
View article: Fatty Acid Binding Protein 4—A Circulating Protein Associated with Peripheral Arterial Disease in Diabetic Patients
Fatty Acid Binding Protein 4—A Circulating Protein Associated with Peripheral Arterial Disease in Diabetic Patients Open
Diabetic patients with peripheral arterial disease (PAD) often suffer from poor clinical outcomes such as limb-loss. Fatty acid binding protein 4 (FABP4) is mainly expressed by adipocytes and is known to play a significant role in the deve…
View article: Burnout and Career Satisfaction Among Canadian Vascular Surgeons
Burnout and Career Satisfaction Among Canadian Vascular Surgeons Open
View article: Transmission of aerosols through pristine and reprocessed N95 respirators
Transmission of aerosols through pristine and reprocessed N95 respirators Open
During the Covid-19 pandemic, pristine and reprocessed N95 respirators are crucial equipment towards limiting nosocomial infections. The NIOSH test certifying the N95 rating, however, poorly simulates aerosols in healthcare settings, limit…