Ori Green
YOU?
Author Swipe
View article: Sensing molecular carbon dioxide: a translational focus for respiratory disease
Sensing molecular carbon dioxide: a translational focus for respiratory disease Open
The last two decades of research on carbon dioxide have demonstrated that CO 2 is far more than a waste product of aerobic metabolism leading to acidosis and that it elicits biological responses directly via non-pH-dependent molecular inte…
View article: Carbon-to-nitrogen atom swap enables direct access to benzimidazoles from drug-like indoles
Carbon-to-nitrogen atom swap enables direct access to benzimidazoles from drug-like indoles Open
The ability to selectively edit organic molecules at the atomic level has the potential to streamline lead discovery and optimization in the pharmaceutical and agrochemical industry. While numerous atom insertion and deletion reactions hav…
View article: Regiodivergent Ring-Expansion of Oxindoles to Quinolinones
Regiodivergent Ring-Expansion of Oxindoles to Quinolinones Open
The development of divergent methods to expedite structure-activity relationship studies is crucial to streamline discovery processes. We developed a rare example of regiodivergent ring expansion to access two regioisomers from a common st…
View article: CCDC 2266361: Experimental Crystal Structure Determination
CCDC 2266361: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2285027: Experimental Crystal Structure Determination
CCDC 2285027: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2285025: Experimental Crystal Structure Determination
CCDC 2285025: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2285026: Experimental Crystal Structure Determination
CCDC 2285026: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Late-Stage Molecular Editing Enabled by Ketone Chain-Walking Isomerization
Late-Stage Molecular Editing Enabled by Ketone Chain-Walking Isomerization Open
Herein, a method for the isomerization of ketones in a manner akin to the chain-walking reaction of alkenes is described. Widely available and inexpensive pyrrolidine and elemental sulfur are deployed as catalysts to achieve this reversibl…
View article: CCDC 2221960: Experimental Crystal Structure Determination
CCDC 2221960: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2221959: Experimental Crystal Structure Determination
CCDC 2221959: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Nitrogen atom insertion into indenes to access isoquinolines
Nitrogen atom insertion into indenes to access isoquinolines Open
We report a convenient protocol for a nitrogen atom insertion into indenes to afford isoquinolines. The strategy further enables the synthesis of pyridines from cyclopentadienes and a facile access to 15 N labelled isoquinolines.
View article: Nitrogen atom insertion into indenes to access isoquinolines
Nitrogen atom insertion into indenes to access isoquinolines Open
We report a convenient protocol for a nitrogen atom insertion into indenes to afford isoquinolines. The reaction uses a combination of commercially available (diacetoxy¬iodo)benzene (PIDA) and ammonium carbamate to furnish a wide range of …
View article: Late-stage diversification of indole skeletons through nitrogen atom insertion
Late-stage diversification of indole skeletons through nitrogen atom insertion Open
Compared with peripheral late-stage transformations mainly focusing on carbon–hydrogen functionalizations, reliable strategies to directly edit the core skeleton of pharmaceutical lead compounds still remain scarce despite the recent flurr…
View article: CCDC 2173003: Experimental Crystal Structure Determination
CCDC 2173003: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2172005: Experimental Crystal Structure Determination
CCDC 2172005: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2172251: Experimental Crystal Structure Determination
CCDC 2172251: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2172008: Experimental Crystal Structure Determination
CCDC 2172008: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2171881: Experimental Crystal Structure Determination
CCDC 2171881: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2171882: Experimental Crystal Structure Determination
CCDC 2171882: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2173004: Experimental Crystal Structure Determination
CCDC 2173004: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2171863: Experimental Crystal Structure Determination
CCDC 2171863: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2174296: Experimental Crystal Structure Determination
CCDC 2174296: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Late-stage diversification of indole skeletons through nitrogen atom insertion
Late-stage diversification of indole skeletons through nitrogen atom insertion Open
Advances in the field of late-stage functionalization have expedited lead-structure discovery and established new opportunities to access valuable molecules. Although many peripheral late-stage transformations, mainly focusing on C–H funct…
View article: Activity-Based Approach for Selective Molecular CO<sub>2</sub> Sensing
Activity-Based Approach for Selective Molecular CO<sub>2</sub> Sensing Open
Carbon dioxide (CO2) impacts every aspect of life, and numerous sensing technologies have been established to detect and monitor this ubiquitous molecule. However, its selective sensing at the molecular level remains an unmet challenge, de…
View article: Enzyme‐Activated, Chemiluminescent Siderophore‐Dioxetane Probes Enable the Selective and Highly Sensitive Detection of Bacterial Pathogens
Enzyme‐Activated, Chemiluminescent Siderophore‐Dioxetane Probes Enable the Selective and Highly Sensitive Detection of Bacterial Pathogens Open
The sensitive detection of bacterial infections is a prerequisite for their successful treatment. The use of a chemiluminescent readout was so far hampered by an insufficient probe enrichment at the pathogens. We coupled siderophore moieti…
View article: Modular Access to Diverse Chemiluminescent Dioxetane‐Luminophores through Convergent Synthesis
Modular Access to Diverse Chemiluminescent Dioxetane‐Luminophores through Convergent Synthesis Open
Adamantyl‐dioxetane luminophores are an important class of chemiluminescent molecular probes for diagnostics and imaging. We have developed a new efficient synthetic route for preparation of adamantyl‐enolether as precursors for dioxetane …
View article: Modular Access to Diverse Chemiluminescent Dioxetane‐Luminophores through Convergent Synthesis
Modular Access to Diverse Chemiluminescent Dioxetane‐Luminophores through Convergent Synthesis Open
Adamantyl‐dioxetane luminophores are an important class of chemiluminescent molecular probes for diagnostics and imaging. We have developed a new efficient synthetic route for preparation of adamantyl‐enolether as precursors for dioxetane …
View article: Injectable Nanocomposite Implants Reduce ROS Accumulation and Improve Heart Function after Infarction
Injectable Nanocomposite Implants Reduce ROS Accumulation and Improve Heart Function after Infarction Open
In a myocardial infarction, blood supply to the left ventricle is abrogated due to blockage of one of the coronary arteries, leading to ischemia, which further triggers the generation of reactive oxygen species (ROS). These sequential proc…
View article: Universal Access to Protease Chemiluminescent Probes through Solid-Phase Synthesis
Universal Access to Protease Chemiluminescent Probes through Solid-Phase Synthesis Open
Protease chemiluminescent probes exhibit extremely high detection sensitivity for monitoring activity of various proteolytic enzymes. However, their synthesis, performed in solution, involves multiple synthetic and purification steps, ther…