Oriana Hoi Yun Yu
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View article: Sodium glucose co‐transporter 2 inhibitors versus dipeptidyl peptidase‐4 inhibitors and the risk of ventricular arrhythmia among patients with type 2 diabetes: A population‐based cohort study
Sodium glucose co‐transporter 2 inhibitors versus dipeptidyl peptidase‐4 inhibitors and the risk of ventricular arrhythmia among patients with type 2 diabetes: A population‐based cohort study Open
Aims To determine whether sodium glucose co‐transporter 2 inhibitors (SGLT2i) use, compared with dipeptidyl peptidase‐4 inhibitors (DPP4i) use, is associated with the risk of ventricular arrhythmias (VA) among patients with type 2 diabetes…
View article: Levothyroxine treatment for subclinical hypothyroidism and risk of adverse renal outcomes: a population-based cohort study
Levothyroxine treatment for subclinical hypothyroidism and risk of adverse renal outcomes: a population-based cohort study Open
In this population-based cohort study, there was no evidence that levothyroxine treatment of subclinical hypothyroidism reduced the risk of adverse renal outcomes. Future studies in different populations and with longer duration of follow-…
View article: The expanding role of GLP-1 receptor agonists: a narrative review of current evidence and future directions
The expanding role of GLP-1 receptor agonists: a narrative review of current evidence and future directions Open
K.B.F. is supported by a William Dawson Scholar award from McGill University. T.M.P. is a Fond de Recherche du Québec-Santé (FRQS) research scholar. M.J.E. holds a James McGill Professor award from McGill University. The funding sources ha…
View article: Target trial emulation of cardiovascular outcome trials of medications used to treat type 2 diabetes using real-world data: a systematic review of observational studies
Target trial emulation of cardiovascular outcome trials of medications used to treat type 2 diabetes using real-world data: a systematic review of observational studies Open
These results suggest that, while RCTs and RWD are concordant in their estimates, the trials lack representativeness. More research is needed on the emulation of cardiovascular outcome trials using RWD to understand how different emulation…
View article: Glucagon-like peptide-1 receptor agonists and risk of suicidality among patients with type 2 diabetes: active comparator, new user cohort study
Glucagon-like peptide-1 receptor agonists and risk of suicidality among patients with type 2 diabetes: active comparator, new user cohort study Open
Objective To determine whether the use of glucagon-like peptide-1 (GLP-1) receptor agonists is associated with an increased risk of suicidal ideation, self-harm, and suicide among patients with type 2 diabetes compared with the use of dipe…
View article: <b>Glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors and the prevention of cirrhosis among patients with type 2 diabetes</b>
<b>Glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors and the prevention of cirrhosis among patients with type 2 diabetes</b> Open
OBJECTIVE: To determine whether glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium-glucose cotransporter-2 (SGLT-2) inhibitors, separately compared with dipeptidyl peptidase-4 (DPP-4) inhibitors, are associated with a …
View article: <b>Glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors and the prevention of cirrhosis among patients with type 2 diabetes</b>
<b>Glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors and the prevention of cirrhosis among patients with type 2 diabetes</b> Open
OBJECTIVE: To determine whether glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium-glucose cotransporter-2 (SGLT-2) inhibitors, separately compared with dipeptidyl peptidase-4 (DPP-4) inhibitors, are associated with a …
View article: Association between use of sodium-glucose co-transporter-2 inhibitor and the risk of incident dementia: a population-based cohort study
Association between use of sodium-glucose co-transporter-2 inhibitor and the risk of incident dementia: a population-based cohort study Open
Objectives To assess the association between sodium-glucose co-transporter-2 inhibitor (SGLT-2i) use and the risk of incident dementia compared with dipeptidyl peptidase-4 inhibitors (DPP-4i) use among individuals with type 2 diabetes. Des…
View article: Metformin and risk of adverse pregnancy outcomes among pregnant women with gestational diabetes in the United Kingdom: A population‐based cohort study
Metformin and risk of adverse pregnancy outcomes among pregnant women with gestational diabetes in the United Kingdom: A population‐based cohort study Open
Aims Metformin is increasingly used off‐label as the treatment of gestational diabetes (GDM). Our objective was to determine if metformin versus insulin initiation is associated with the adverse pregnancy outcomes. Materials and Methods We…
View article: The Prevalent New‐User Design to Study Drug–Drug Interactions: The Example of Sulfonylureas and Warfarin Interaction on the Risk of Severe Hypoglycemia
The Prevalent New‐User Design to Study Drug–Drug Interactions: The Example of Sulfonylureas and Warfarin Interaction on the Risk of Severe Hypoglycemia Open
Purpose The optimal design for pharmacoepidemiologic drug–drug interactions (DDIs) studies is unclear. Using the association between concomitant use of sulfonylureas and warfarin and the risk of severe hypoglycemia as a case study, a DDI w…
View article: A systematic review and meta-analysis comparing outcomes between using subcutaneous insulin and continuous insulin infusion in managing adult patients with diabetic ketoacidosis
A systematic review and meta-analysis comparing outcomes between using subcutaneous insulin and continuous insulin infusion in managing adult patients with diabetic ketoacidosis Open
Treatment of DKA with subcutaneous insulin may be a safe and effective alternative to IV insulin in selected patients. The limited available evidence underscores the need for further studies to explore optimal dosing, patient selection cri…
View article: Effect of combination treatment with glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors on incidence of cardiovascular and serious renal events: population based cohort study
Effect of combination treatment with glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors on incidence of cardiovascular and serious renal events: population based cohort study Open
Objective To determine whether the combined use of glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose cotransporter-2 (SGLT-2) inhibitors is associated with a decreased risk of major adverse cardiovascular events and seri…
View article: Sodium‐glucose cotransporter‐2 inhibitors and the risk of lung cancer among patients with type 2 diabetes
Sodium‐glucose cotransporter‐2 inhibitors and the risk of lung cancer among patients with type 2 diabetes Open
We sought to determine whether the use of sodium‐glucose cotransporter‐2 (SGLT‐2) inhibitors is associated with a decreased risk of incident lung cancers among patients with type 2 diabetes. We assembled a new‐user, active comparator cohor…
View article: Levothyroxine initiation and the risk of pregnancy loss among pregnant women with subclinical hypothyroidism: An observational study emulating a target trial
Levothyroxine initiation and the risk of pregnancy loss among pregnant women with subclinical hypothyroidism: An observational study emulating a target trial Open
Background While the benefits of levothyroxine are well‐established for overt hypothyroidism, they are unclear for subclinical hypothyroidism (SCH) among pregnant women. Objective To estimate the effect of initiation of levothyroxine on pr…
View article: Dipeptidyl peptidase-4 inhibitors and the risk of skin cancer among patients with type 2 diabetes: a UK population-based cohort study
Dipeptidyl peptidase-4 inhibitors and the risk of skin cancer among patients with type 2 diabetes: a UK population-based cohort study Open
Introduction The dipeptidyl peptidase-4 (DPP-4) enzyme significantly influences carcinogenic pathways in the skin. The objective of this study was to determine whether DPP-4 inhibitors are associated with the incidence of melanoma and nonm…
View article: Long‐acting insulin analogues and the risk of diabetic retinopathy among patients with type 2 diabetes: A population‐based cohort study
Long‐acting insulin analogues and the risk of diabetic retinopathy among patients with type 2 diabetes: A population‐based cohort study Open
Aim To determine whether the use of long‐acting insulin analogues is associated with an increased risk of incident diabetic retinopathy (DR) among patients with type 2 diabetes. Methods Using data from the Clinical Practice Research Datali…
View article: Metformin and Cancer: Solutions to a Real-World Evidence Failure
Metformin and Cancer: Solutions to a Real-World Evidence Failure Open
The quest to repurpose metformin, an antidiabetes drug, as an agent for cancer prevention and treatment, which began in 2005 with an observational study that reported a reduction in cancer incidence among metformin users, generated extensi…
View article: Études de cas Virilisation causée par une hyperthécose nodulaire ovarienne chez une femme postménopausée
Études de cas Virilisation causée par une hyperthécose nodulaire ovarienne chez une femme postménopausée Open
[Voir la version anglaise de l’article ici : www.cmaj.ca/lookup/doi/10.1503/cmaj.220685][1] Points clés Une femme de 55 ans (nullipare) a été dirigée vers la clinique d’endocrinologie pour des problèmes de pilosité faciale croissante néces…
View article: Use of metformin and insulin among pregnant women with gestation diabetes in the United Kingdom: A <scp>population‐based</scp> cohort study
Use of metformin and insulin among pregnant women with gestation diabetes in the United Kingdom: A <span>population‐based</span> cohort study Open
Aims The contemporary prescription patterns of antidiabetic drugs following guideline changes recommending metformin as first‐line gestational diabetes (GDM) pharmacotherapy is underexplored. We aimed to examined use of metformin and insul…
View article: Association of adverse respiratory events with sodium-glucose cotransporter 2 inhibitors versus dipeptidyl peptidase 4 inhibitors among patients with type 2 diabetes in South Korea: a nationwide cohort study
Association of adverse respiratory events with sodium-glucose cotransporter 2 inhibitors versus dipeptidyl peptidase 4 inhibitors among patients with type 2 diabetes in South Korea: a nationwide cohort study Open
View article: Sulphonylureas versus metformin and the risk of ventricular arrhythmias among people with type 2 diabetes: A population‐based cohort study
Sulphonylureas versus metformin and the risk of ventricular arrhythmias among people with type 2 diabetes: A population‐based cohort study Open
Aim To determine whether the use of sulphonylurea monotherapy, compared with metformin monotherapy, is associated with an increased risk of ventricular arrhythmia (VA) among patients initiating pharmacotherapy for type 2 diabetes. Research…
View article: Occupation as a gendered-role and outcome in systemic sclerosis
Occupation as a gendered-role and outcome in systemic sclerosis Open
Objective: Sex and gender are of growing scientific interest in disease onset and course. While sex differences have been shown to exist in systemic sclerosis, there is a paucity of data on gender. Our objective was to examine the associat…
View article: Virilization caused by ovarian nodular hyperthecosis in a postmenopausal woman
Virilization caused by ovarian nodular hyperthecosis in a postmenopausal woman Open
KEY POINTS A 55-year-old woman (gravida 0) was referred to the endocrine clinic with increasing facial hair necessitating laser removal, acne, deepening of voice and increased libido for more than 1 year. Although menopause had occurred 5 …
View article: Treating type 2 diabetes: moving towards precision medicine
Treating type 2 diabetes: moving towards precision medicine Open
Type 2 diabetes is a prevalent condition with a rate of 6059 cases per 100 000 globally reported in 2017, and forecasted to increase to 7079 individuals per 100 000 by 2030.1 Several glucose-lowering medications have been developed to trea…
View article: Novel antihyperglycaemic drugs and prevention of chronic obstructive pulmonary disease exacerbations among patients with type 2 diabetes: population based cohort study
Novel antihyperglycaemic drugs and prevention of chronic obstructive pulmonary disease exacerbations among patients with type 2 diabetes: population based cohort study Open
Objective To determine whether the use of glucagon-like peptide 1 (GLP-1) receptor agonists, dipeptidyl peptidase 4 (DPP-4) inhibitors, and sodium-glucose co-transporter-2 (SGLT-2) inhibitors, separately, is associated with a decreased ris…
View article: Characteristics of new users of recent antidiabetic drugs in Canada and the United Kingdom
Characteristics of new users of recent antidiabetic drugs in Canada and the United Kingdom Open
Background Characteristics of patients using newer 2 nd and 3 rd line antidiabetic drugs in a real-world setting are poorly understood. We described the characteristics of new users of sodium-glucose co-transporter-2 inhibitors (SGLT-2i), …
View article: Sodium-Glucose Co-Transporter 2 inhibitors and the Short-term Risk of Bladder Cancer: An International Multi-Site Cohort Study
Sodium-Glucose Co-Transporter 2 inhibitors and the Short-term Risk of Bladder Cancer: An International Multi-Site Cohort Study Open
Objective: To determine whether sodium-glucose co-transporter 2 (SGLT2) inhibitors, compared with glucagon-like peptide-receptor agonists (GLP-1RAs) or dipeptidyl peptidase-4 (DPP4) inhibitors are associated with an incr…
View article: Sodium–Glucose Cotransporter 2 Inhibitors and the Short-term Risk of Bladder Cancer: An International Multisite Cohort Study
Sodium–Glucose Cotransporter 2 Inhibitors and the Short-term Risk of Bladder Cancer: An International Multisite Cohort Study Open
OBJECTIVE To determine whether sodium–glucose cotransporter 2 (SGLT2) inhibitors, compared with glucagon-like peptide 1 receptor agonists (GLP-1RAs) or dipeptidyl peptidase 4 (DPP-4) inhibitors, are associated with an increased risk of ear…
View article: Sodium-Glucose Co-Transporter 2 inhibitors and the Short-term Risk of Bladder Cancer: An International Multi-Site Cohort Study
Sodium-Glucose Co-Transporter 2 inhibitors and the Short-term Risk of Bladder Cancer: An International Multi-Site Cohort Study Open
Objective: To determine whether sodium-glucose co-transporter 2 (SGLT2) inhibitors, compared with glucagon-like peptide-receptor agonists (GLP-1RAs) or dipeptidyl peptidase-4 (DPP4) inhibitors are associated with an incr…
View article: Atorvastatin lowers serum calcium levels in lithium-users: results from a randomized controlled trial
Atorvastatin lowers serum calcium levels in lithium-users: results from a randomized controlled trial Open