Oriane Cédile
YOU?
Author Swipe
View article: Ixazomib treatment has a dual effect on bone remodeling in patients with multiple myeloma: follow-up results from a phase 2 clinical study
Ixazomib treatment has a dual effect on bone remodeling in patients with multiple myeloma: follow-up results from a phase 2 clinical study Open
Myeloma bone disease (MBD), a common complication in multiple myeloma (MM), causes increased risk of fractures leading to morbidity and impaired quality of life for patients. Proteasome inhibitors, a cancer-targeting therapy for MM, have b…
View article: Performance of Rapid Clonotyping of Chronic Lymphocytic Leukemia Using Flongle Flow‐Cell Nanopore Sequencing of <scp>IGH</scp> Rearrangements
Performance of Rapid Clonotyping of Chronic Lymphocytic Leukemia Using Flongle Flow‐Cell Nanopore Sequencing of <span>IGH</span> Rearrangements Open
Background Clonotyping of immunoglobulin heavy chain (IGH) gene rearrangements is critical for diagnosis, prognostication, and measurable residual disease monitoring in chronic lymphocytic leukemia (CLL). Although short‐read next‐generatio…
View article: Monitoring ctDNA in aggressive B-cell lymphoma: a prospective correlative study of ctDNA kinetics and PET-CT metrics
Monitoring ctDNA in aggressive B-cell lymphoma: a prospective correlative study of ctDNA kinetics and PET-CT metrics Open
Positron emission tomography–computed tomography (PET-CT) is recommended for response evaluation in aggressive large B-cell lymphoma (LBCL) but cannot detect minimal residual disease (MRD). Circulating tumor DNA (ctDNA) has emerged as a pr…
View article: Liquid Biopsy for Enhanced Specificity in Identifying Somatic Mutations in Aggressive Non‐Hodgkin Large B‐Cell Lymphoma: A Comparative Study of Cell‐Free <scp>DNA</scp> and Formalin‐Fixed Paraffin‐Embedded Tissue
Liquid Biopsy for Enhanced Specificity in Identifying Somatic Mutations in Aggressive Non‐Hodgkin Large B‐Cell Lymphoma: A Comparative Study of Cell‐Free <span>DNA</span> and Formalin‐Fixed Paraffin‐Embedded Tissue Open
Introduction Formalin‐fixed paraffin‐embedded (FFPE) tumor biopsy is the current mainstay of genotyping, but is limited by its invasiveness and tumor heterogeneity. Plasma cell‐free DNA (cfDNA) constitutes a minimally invasive alternative …
View article: A Case‐Driven Multi‐Omics Analysis for Longitudinal Ibrutinib Response Evaluation of Patients With Chronic Lymphocytic Leukemia
A Case‐Driven Multi‐Omics Analysis for Longitudinal Ibrutinib Response Evaluation of Patients With Chronic Lymphocytic Leukemia Open
Patients with chronic lymphocytic leukemia (CLL) undergoing ibrutinib treatment often experience incomplete response, yet the molecular level underlying clonal inertia remains to be explored. We investigated the molecular and clinical dyna…
View article: Ixazomib Treatment Has a Dual Effect on Bone Remodeling in Patients with Multiple Myeloma: Follow-Up Results from a Phase 2 Clinical Study
Ixazomib Treatment Has a Dual Effect on Bone Remodeling in Patients with Multiple Myeloma: Follow-Up Results from a Phase 2 Clinical Study Open
View article: Molecular Composition and Kinetics of B Cells During Ibrutinib Treatment in Patients with Chronic Lymphocytic Leukemia
Molecular Composition and Kinetics of B Cells During Ibrutinib Treatment in Patients with Chronic Lymphocytic Leukemia Open
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of B cells due to constitutive B-cell receptor (BCR) signaling, leading to apoptosis resistance and increased proliferation. This study evaluates the effects of the Br…
View article: Correction: Chimeric Antigen Receptor T Cells Targeting CD79b Show Efficacy in Lymphoma with or without Cotargeting CD19
Correction: Chimeric Antigen Receptor T Cells Targeting CD79b Show Efficacy in Lymphoma with or without Cotargeting CD19 Open
View article: SWIGH-SCORE: A translational light-weight approach in computational detection of rearranged immunoglobulin heavy chain to be used in monoclonal lymphoproliferative disorders
SWIGH-SCORE: A translational light-weight approach in computational detection of rearranged immunoglobulin heavy chain to be used in monoclonal lymphoproliferative disorders Open
We present a lightweight tool for clonotyping and measurable residual disease (MRD) assessment in monoclonal lymphoproliferative disorders. It is a translational method that enables computational detection of rearranged immunoglobulin heav…
View article: The potential of 3rd‐generation nanopore sequencing for B‐cell clonotyping in lymphoproliferative disorders
The potential of 3rd‐generation nanopore sequencing for B‐cell clonotyping in lymphoproliferative disorders Open
Lymphoid malignancies are characterized by clonal cell expansion, often identifiable by unique immunoglobulin rearrangements. Heavy (IGH) and light‐chain gene usage offers diagnostic insights and enables sensitive residual disease detectio…
View article: Toward Cytogenomics
Toward Cytogenomics Open
View article: PB2386: ASSESSMENT OF NANOPORE LONG-READ WHOLE-GENOME SEQUENCING FOR THE DETECTION OF LARGE CHROMOSOMAL STRUCTURAL VARIANTS IN MANTLE CELL LYMPHOMA
PB2386: ASSESSMENT OF NANOPORE LONG-READ WHOLE-GENOME SEQUENCING FOR THE DETECTION OF LARGE CHROMOSOMAL STRUCTURAL VARIANTS IN MANTLE CELL LYMPHOMA Open
Topic: 20. Lymphoma Biology & Translational Research Background: Detection of t(11;14)(q13;q32), a hallmark of mantle cell lymphoma (MCL), remains challenging when relying on next-generation sequencing (NGS) in contrast to fluorescence in-…
View article: PB2394: PTPRJ AS A ROBUST DIFFERENTIATING MARKER IN MANTLE CELL LYMPHOMA
PB2394: PTPRJ AS A ROBUST DIFFERENTIATING MARKER IN MANTLE CELL LYMPHOMA Open
Topic: 20. Lymphoma Biology & Translational Research Background: Mantle cell lymphoma (MCL) is an often aggressive B-cell neoplasm, usually characterized by translocation t(11;14)(q13:q32) juxtapositioning the cyclin D1 locus to the immuno…
View article: Cell‐free <scp>DNA</scp> for detection of clonal B cells in diffuse large B cell lymphoma by sequencing
Cell‐free <span>DNA</span> for detection of clonal B cells in diffuse large B cell lymphoma by sequencing Open
Introduction Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma in the western world. It is highly heterogeneous with a variable clinical course, but curable with chemo‐immunotherapy in up to 70% of all cases. The lymphoma p…
View article: Data from Chimeric Antigen Receptor T Cells Targeting CD79b Show Efficacy in Lymphoma with or without Cotargeting CD19
Data from Chimeric Antigen Receptor T Cells Targeting CD79b Show Efficacy in Lymphoma with or without Cotargeting CD19 Open
Purpose:T cells engineered to express a chimeric antigen receptor (CAR) against CD19 have recently been FDA approved for the treatment of relapsed or refractory large B-cell lymphoma. Despite the success and curative potential of CD19 CAR …
View article: Data from Chimeric Antigen Receptor T Cells Targeting CD79b Show Efficacy in Lymphoma with or without Cotargeting CD19
Data from Chimeric Antigen Receptor T Cells Targeting CD79b Show Efficacy in Lymphoma with or without Cotargeting CD19 Open
Purpose:T cells engineered to express a chimeric antigen receptor (CAR) against CD19 have recently been FDA approved for the treatment of relapsed or refractory large B-cell lymphoma. Despite the success and curative potential of CD19 CAR …
View article: Supplementary Data from Chimeric Antigen Receptor T Cells Targeting CD79b Show Efficacy in Lymphoma with or without Cotargeting CD19
Supplementary Data from Chimeric Antigen Receptor T Cells Targeting CD79b Show Efficacy in Lymphoma with or without Cotargeting CD19 Open
Supplementary Materials and Data
View article: Supplementary Data from Chimeric Antigen Receptor T Cells Targeting CD79b Show Efficacy in Lymphoma with or without Cotargeting CD19
Supplementary Data from Chimeric Antigen Receptor T Cells Targeting CD79b Show Efficacy in Lymphoma with or without Cotargeting CD19 Open
Supplementary Materials and Data
View article: Reproducibility of low-level residual myeloma immunoglobulin detection using ultra-deep sequencing
Reproducibility of low-level residual myeloma immunoglobulin detection using ultra-deep sequencing Open
Multiple myeloma, a mature B-cell neoplasm, is the second most common hematologic malignancy. Despite advancements in treatment, the disease remains incurable, with more than 100,000 annual deaths worldwide. As recommended by the Internati…
View article: Methylation microarray-based detection of clinical copy-number aberrations in CLL benchmarked to standard FISH analysis
Methylation microarray-based detection of clinical copy-number aberrations in CLL benchmarked to standard FISH analysis Open
Copy-number aberrations (CNAs) are assessed using FISH analysis in diagnostics of chronic lymphocytic leukemia (CLL), but CNAs can also be extrapolated from Illumina BeadChips developed for genome-wide methylation microarray screening. Inc…
View article: PB2158: EXPLORING THE BIOLOGICAL ROLE OF LILRA4 IN MANTLE CELL LYMPHOMA
PB2158: EXPLORING THE BIOLOGICAL ROLE OF LILRA4 IN MANTLE CELL LYMPHOMA Open
Background: Mantle cell lymphoma (MCL) is a heterogeneous, rare, and aggressive subtype of B cell non-Hodgkin’s lymphomas, with a generally poor prognosis. In a previous study, we found the leukocyte-immunoglobulin-like receptor subfamily …
View article: Impact of Molecular Heterogeneity in B cell Malignancies
Impact of Molecular Heterogeneity in B cell Malignancies Open
View article: Exploration of residual disease in stem cell products from mantle cell lymphoma using next-generation sequencing
Exploration of residual disease in stem cell products from mantle cell lymphoma using next-generation sequencing Open
View article: Surgical resection of glioblastomas induces pleiotrophin-mediated self-renewal of glioblastoma stem cells in recurrent tumors
Surgical resection of glioblastomas induces pleiotrophin-mediated self-renewal of glioblastoma stem cells in recurrent tumors Open
Background Glioblastomas are highly resistant to therapy, and virtually all patients experience tumor recurrence after standard-of-care treatment. Surgical tumor resection is a cornerstone in glioblastoma therapy, but its impact on cellula…
View article: Investigation of Circulating DNA Integrity After Blood Collection
Investigation of Circulating DNA Integrity After Blood Collection Open
Concentrations of circulating DNA in blood plasma were compared using NanoDrop, Qubit, quantitative PCR and Bioanalyzer, and DNA integrity was evaluated with the Bioanalyzer according to the time of plasma preparation.
View article: Detailed characterization of the transcriptome of single B cells in mantle cell lymphoma suggesting a potential use for SOX4
Detailed characterization of the transcriptome of single B cells in mantle cell lymphoma suggesting a potential use for SOX4 Open
View article: Perspective: sensitive detection of residual lymphoproliferative disease by NGS and clonal rearrangements—how low can you go?
Perspective: sensitive detection of residual lymphoproliferative disease by NGS and clonal rearrangements—how low can you go? Open
Malignant lymphoproliferative disorders collectively constitute a large fraction of the hematological cancers, ranging from indolent to highly aggressive neoplasms. Being a diagnostically important hallmark, clonal gene rearrangements of t…
View article: 10x Cell Ranger output, 8 samples
10x Cell Ranger output, 8 samples Open
10x Cell Ranger output from 8 patients with mantle cell lymphoma.
View article: 10x Cell Ranger output, 8 samples
10x Cell Ranger output, 8 samples Open
10x Cell Ranger output from 8 patients with mantle cell lymphoma.
View article: Distal chromosome 1q aberrations and initial response to ibrutinib in central nervous system relapsed mantle cell lymphoma
Distal chromosome 1q aberrations and initial response to ibrutinib in central nervous system relapsed mantle cell lymphoma Open