Explanipedia

Syntaxin-1 is necessary for UNC5A-C/Netrin-1-dependent macropinocytosis and chemorepulsion Open

Ramón Martínez‐Mármol, Ashraf Muhaisen, Tiziana Cotrufo, Cristina Roselló-Busquets, Oriol Ros , et al. · 2023

Introduction Brain connectivity requires correct axonal guidance to drive axons to their appropriate targets. This process is orchestrated by guidance cues that exert attraction or repulsion to developing axons. However, the intricacies of…

Subcellular second messenger networks drive distinct repellent-induced axon behaviors Open

Sarah Baudet, Yvrick Zagar, F. Hoffmann-La Roche, Claudia Gomez-Bravo, Sandrine Couvet , et al. · 2023

Second messengers, including cAMP, cGMP and Ca 2+ are often placed in an integrating position to combine the extracellular cues that orient growing axons in the developing brain. This view suggests that axon repellents share the same set o…

Subcellular second messenger networks drive distinct repellent-induced axon behaviors Open

Sarah Baudet, Yvrick Zagar, Frédéric Roche, C Gomez Bravo, Sandrine Couvet , et al. · 2023

A bstract Second messengers, including cAMP, cGMP and Ca 2+ are often placed in an integrating position to combine the extracellular cues that orient growing axons in the developing brain. This view suggests that axon repellents share the …

Axon pathfinding and targeting: (R)evolution of insights from in vitro assays Open

Oriol Ros, Xavier Nicol · 2022

Syntaxin-1 is necessary for UNC5/Netrin-1-dependent macropinocytosis and chemorepulsion Open

Ramón Martínez‐Mármol, Ashraf Muhaisen, Tiziana Cotrufo, Cristina Roselló-Busquets, Marc Hernaiz-Llorens , et al. · 2021

Brain connectivity requires correct axonal guidance to drive axons to their appropriate targets. This process is orchestrated by guidance cues that exert attraction or repulsion to developing axons. However, the intricacies of the cellular…

SpiCee: A Genetic Tool for Subcellular and Cell-Specific Calcium Manipulation Open

Oriol Ros, Sarah Baudet, Yvrick Zagar, Karine Loulier, F. Hoffmann-La Roche , et al. · 2020

SponGee: A Genetic Tool for Subcellular and Cell-Specific cGMP Manipulation Open

Oriol Ros, Yvrick Zagar, Solène Ribes, Sarah Baudet, Karine Loulier , et al. · 2019

SpiCee: A Genetic Tool for Subcellular and Cell-Specific Calcium Manipulation Open

Oriol Ros, Yvrick Zagar, Karine Loulier, Sandrine Couvet, Asadollah Aghaie , et al. · 2019

Spongee: A Genetic Tool for Subcellular and Cell-Specific cGMP Manipulation Open

Oriol Ros, Solène Ribes, Karine Loulier, Sandrine Couvet, Yvrick Zagar , et al. · 2019

Syntaxin-1/TI-VAMP SNAREs interact with Trk receptors and are required for neurotrophin-dependent outgrowth Open

Giulia Fuschini, Tiziana Cotrufo, Oriol Ros, Ashraf Muhaisen, Rosa Andrés , et al. · 2018

SNARE proteins are essential components of the machinery that regulates vesicle trafficking and exocytosis. Their role is critical for the membrane-fusion processes that occur during neurotransmitter release. However, research in the last …

A conserved role for Syntaxin-1 in pre- and post-commissural midline axonal guidance in fly, chick, and mouse Open

Oriol Ros, Pablo José Barrecheguren, Tiziana Cotrufo, Martina Schaettin, Cristina Roselló-Busquets , et al. · 2018

Axonal growth and guidance rely on correct growth cone responses to guidance cues. Unlike the signaling cascades that link axonal growth to cytoskeletal dynamics, little is known about the crosstalk mechanisms between guidance and membrane…

Linking activity‐dependent control of axon initial segment structure to the cytoskeleton (Commentary on Evans <i>et al</i>. (2017)) Open

Oriol Ros, Xavier Nicol · 2017

International audience

A plasma membrane microdomain compartmentalizes ephrin-generated cAMP signals to prune developing retinal axon arbors Open

Stefania Averaimo, Ahlem Assali, Oriol Ros, Sandrine Couvet, Yvrick Zagar , et al. · 2016

The development of neuronal circuits is controlled by guidance molecules that are hypothesized to interact with the cholesterol-enriched domains of the plasma membrane termed lipid rafts. Whether such domains enable local intracellular sig…

Regulation of Patterned Dynamics of Local Exocytosis in Growth Cones by Netrin-1 Open

Oriol Ros, Tiziana Cotrufo, Ramón Martínez‐Mármol, Eduardo Soriano · 2015

Axonal guidance and synaptic specification depends on specific signaling mechanisms that occur in growth cones. While several signaling pathways implicated in cone navigation have been identified, membrane dynamics in growth cones remains …

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