Orlagh Carroll
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View article: In Utero Exposure to Chikungunya and Child Morbimortality: A Population-Based Longitudinal Study
In Utero Exposure to Chikungunya and Child Morbimortality: A Population-Based Longitudinal Study Open
Background: Chikungunya is a growing public health threat linked to climate change. Vertical transmission is reported, but the long-term effect of in-utero Chikungunya exposure is not known. Methods: This was a matched cohort study of chil…
View article: Non-invasive respiratory support in paediatric critical care: protocol for a cohort study emulating the FIRST-line support for Assistance in Breathing in Children (FIRST-ABC) step-up randomised clinical trial using routinely collected data from the Paediatric Intensive Care Audit Network (PICANet) database
Non-invasive respiratory support in paediatric critical care: protocol for a cohort study emulating the FIRST-line support for Assistance in Breathing in Children (FIRST-ABC) step-up randomised clinical trial using routinely collected data from the Paediatric Intensive Care Audit Network (PICANet) database Open
Introduction The development of the target trial emulation (TTE) methodology has enhanced the conduct of non-randomised studies. By leveraging readily available routinely collected data, TTEs offer opportunities for complementing randomise…
View article: Long‐term outcomes following alternative second‐line oral glucose‐lowering treatments: Results from the real‐world progression in type 2 diabetes mellitus United Kingdom ( <scp>RAPIDS</scp> ‐ <scp>UK</scp> ) model
Long‐term outcomes following alternative second‐line oral glucose‐lowering treatments: Results from the real‐world progression in type 2 diabetes mellitus United Kingdom ( <span>RAPIDS</span> ‐ <span>UK</span> ) model Open
Aims To compare long‐term complications for people with type 2 diabetes mellitus (T2DM) following second‐line treatment in routine practice with sulphonylureas (SU), dipeptidyl peptidase‐4 inhibitors (DPP4i), or sodium‐glucose co‐transport…
View article: Syphilis Exposure During Pregnancy and Childhood Hospital Admissions in Brazil
Syphilis Exposure During Pregnancy and Childhood Hospital Admissions in Brazil Open
Importance While the short-term impacts of congenital syphilis are well documented, the long-term outcomes and effects on children exposed to syphilis during pregnancy but without congenital infection detected at birth remain unclear. Obje…
View article: A nationwide longitudinal investigation on the role of prenatal exposure to infectious diseases on the onset of chronic conditions in children and adolescents in Brazil
A nationwide longitudinal investigation on the role of prenatal exposure to infectious diseases on the onset of chronic conditions in children and adolescents in Brazil Open
Background In utero exposure to infections might set the stage for a chain of events leading to a wide spectrum of long-term health outcomes observed in children and adolescents. This proposal aims to investigate whether syphilis, zika, de…
View article: Going beyond randomised controlled trials to assess treatment effect heterogeneity across target populations
Going beyond randomised controlled trials to assess treatment effect heterogeneity across target populations Open
Methods have been developed for transporting evidence from randomised controlled trials (RCTs) to target populations. However, these approaches allow only for differences in characteristics observed in the RCT and real‐world data (overt he…
View article: A nationwide longitudinal investigation on the role of prenatal exposure to infectious diseases on the onset of chronic conditions in children and adolescents in Brazil
A nationwide longitudinal investigation on the role of prenatal exposure to infectious diseases on the onset of chronic conditions in children and adolescents in Brazil Open
Background In utero exposure to infections might set the stage for a chain of events leading to a wide spectrum of long-term health outcomes observed in children and adolescents. This proposal aims to investigate whether syphilis, zika, de…
View article: Comparative effectiveness of second line oral antidiabetic treatments among people with type 2 diabetes mellitus: emulation of a target trial using routinely collected health data
Comparative effectiveness of second line oral antidiabetic treatments among people with type 2 diabetes mellitus: emulation of a target trial using routinely collected health data Open
Objective To compare the effectiveness of three commonly prescribed oral antidiabetic drugs added to metformin for people with type 2 diabetes mellitus requiring second line treatment in routine clinical practice. Design Cohort study emula…
View article: Using automated text classification to explore uncertainty in NICE appraisals for drugs for rare diseases
Using automated text classification to explore uncertainty in NICE appraisals for drugs for rare diseases Open
Objective This study examined the application, feasibility, and validity of supervised learning models for text classification in appraisals for rare disease treatments (RDTs) in relation to uncertainty, and analyzed differences between ap…
View article: Can the application of machine learning to electronic health records guide antibiotic prescribing decisions for suspected urinary tract infection in the Emergency Department?
Can the application of machine learning to electronic health records guide antibiotic prescribing decisions for suspected urinary tract infection in the Emergency Department? Open
Urinary tract infections (UTIs) are a major cause of emergency hospital admissions, but it remains challenging to diagnose them reliably. Application of machine learning (ML) to routine patient data could support clinical decision-making. …
View article: Can the application of machine learning to electronic health records guide antibiotic prescribing decisions for suspected urinary tract infection in the Emergency Department?
Can the application of machine learning to electronic health records guide antibiotic prescribing decisions for suspected urinary tract infection in the Emergency Department? Open
Background Urinary tract infections (UTIs) are a major cause of emergency hospital admissions, but it remains challenging to diagnose them reliably. Application of machine learning (ML) to routine patient data could support clinical decisi…
View article: Development of risk prediction models to predict urine culture growth for adults with suspected urinary tract infection in the emergency department: protocol for an electronic health record study from a single UK university hospital
Development of risk prediction models to predict urine culture growth for adults with suspected urinary tract infection in the emergency department: protocol for an electronic health record study from a single UK university hospital Open
Background:Urinary tract infection (UTI) is a leading cause of hospital admissions and is diagnosed based on urinary symptoms and microbiological cultures. Due to lags in the availability of culture results of up to 72 hours, and the limit…
View article: Development of risk prediction models to predict urine culture growth for adults with suspected urinary tract infection in the emergency department: protocol for an electronic health record study from a single UK university hospital
Development of risk prediction models to predict urine culture growth for adults with suspected urinary tract infection in the emergency department: protocol for an electronic health record study from a single UK university hospital Open
Background: Urinary tract infection (UTI) is a leading cause of hospital admissions and is diagnosed based on urinary symptoms and microbiological cultures. Due to lags in the availability of culture results of up to 72 hours, and the limi…
View article: Development of risk prediction models to predict urine culture growth for patients with suspected urinary tract infection in the emergency department: protocol for an electronic health record study from a single UK hospital
Development of risk prediction models to predict urine culture growth for patients with suspected urinary tract infection in the emergency department: protocol for an electronic health record study from a single UK hospital Open
Background: Urinary tract infection (UTI) is a leading cause of hospital admissions and is diagnosed based on urinary symptoms and microbiological cultures. Due to lags in the availability of culture results of up to 72 hours, and the limi…
View article: Additional file 2 of How are missing data in covariates handled in observational time-to-event studies in oncology? A systematic review
Additional file 2 of How are missing data in covariates handled in observational time-to-event studies in oncology? A systematic review Open
Additional file 2 This contains the data extraction spreadsheet, stored as a.xls file.