Ian M. Orme
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View article: Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis
Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis Open
The inhibition of apoptosis of infected host cells is a well-known but poorly understood function of pathogenic mycobacteria. We show that inactivation of the secA2 gene in Mycobacterium tuberculosis, which encodes a component of a virulen…
View article: Vaccination of guinea pigs with BCGΔBCG1419c transiently reduces hematogenous spread of<i>M. tuberculosis</i>to the spleen
Vaccination of guinea pigs with BCGΔBCG1419c transiently reduces hematogenous spread of<i>M. tuberculosis</i>to the spleen Open
The guinea pig has proven to be a reliable model for testing vaccine candidates against tuberculosis (TB) because of its capacity to produce human-like disease associated to primary TB, thus providing a more stringent test of the ability o…
View article: Trying to See the Forest through the Trees: Deciphering the Nature of Memory Immunity to Mycobacterium tuberculosis
Trying to See the Forest through the Trees: Deciphering the Nature of Memory Immunity to Mycobacterium tuberculosis Open
The purpose of vaccination against tuberculosis and other diseases is to establish a heightened state of acquired specific resistance in which the memory immune response is capable of mediating an accelerated and magnified expression of pr…
View article: Biology of clinical strains of Mycobacterium tuberculosis with varying levels of transmission
Biology of clinical strains of Mycobacterium tuberculosis with varying levels of transmission Open
Transmission of Mycobacterium tuberculosis bacilli from one individual to another is the basis of the disease process. While considerable emphasis has been placed on the role of host mechanisms of resistance in establishing or preventing n…
View article: GI-19007, a Novel Saccharomyces cerevisiae-Based Therapeutic Vaccine against Tuberculosis
GI-19007, a Novel Saccharomyces cerevisiae-Based Therapeutic Vaccine against Tuberculosis Open
As yet, very few vaccine candidates with activity in animals against Mycobacterium tuberculosis infection have been tested as therapeutic postexposure vaccines. We recently described two pools of mycobacterial proteins with this activity, …
View article: Effect of bacillus Calmette-Guérin vaccination on CD4+Foxp3+ T cells during acquired immune response to <i>Mycobacterium tuberculosis</i> infection
Effect of bacillus Calmette-Guérin vaccination on CD4+Foxp3+ T cells during acquired immune response to <i>Mycobacterium tuberculosis</i> infection Open
Increasing information has shown that many newly emerging strains of Mycobacterium tuberculosis, including the highly prevalent and troublesome Beijing family of strains, can potently induce the emergence of Foxp3+ CD4 Tregs. Although the …
View article: The Efficacy of the BCG Vaccine against Newly Emerging Clinical Strains of Mycobacterium tuberculosis
The Efficacy of the BCG Vaccine against Newly Emerging Clinical Strains of Mycobacterium tuberculosis Open
To date, most new vaccines against Mycobacterium tuberculosis, including new recombinant versions of the current BCG vaccine, have usually been screened against the laboratory strains H37Rv or Erdman. In this study we took advantage of our…
View article: Human IL-32 expression protects mice against a hypervirulent strain of <i>Mycobacterium tuberculosis</i>
Human IL-32 expression protects mice against a hypervirulent strain of <i>Mycobacterium tuberculosis</i> Open
Significance Interleukin-32 (IL-32) is induced by IL-1β, Toll-like receptor agonists, and nucleotide oligomerization domain as well as by Mycobacterium tuberculosis ( MTB ). Expression of human IL-32γ in the lungs of mice reduced the burde…