Orr-El Weizman
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View article: Developing synthetic tools to decipher the tumor–immune interactome
Developing synthetic tools to decipher the tumor–immune interactome Open
The ability of immune cells to directly interact with transformed cells is an essential component of immune surveillance and critical for optimal tissue function. The tumor–immune interactome (the collective cellular interactions between o…
View article: Type 2 Dendritic Cells Orchestrate a Local Immune Circuit to Confer Antimetastatic Immunity
Type 2 Dendritic Cells Orchestrate a Local Immune Circuit to Confer Antimetastatic Immunity Open
The progression of transformed primary tumors to metastatic colonization is a lethal determinant of disease outcome. Although circulating adaptive and innate lymphocyte effector responses are required for effective antimetastatic immunity,…
View article: IL-18BP mediates the balance between protective and pathological immune responses to Toxoplasma gondii
IL-18BP mediates the balance between protective and pathological immune responses to Toxoplasma gondii Open
View article: Infection induces tissue-resident memory NK cells that safeguard tissue health
Infection induces tissue-resident memory NK cells that safeguard tissue health Open
View article: Neuroinvasion of SARS-CoV-2 in human and mouse brain
Neuroinvasion of SARS-CoV-2 in human and mouse brain Open
Although COVID-19 is considered to be primarily a respiratory disease, SARS-CoV-2 affects multiple organ systems including the central nervous system (CNS). Yet, there is no consensus on the consequences of CNS infections. Here, we used th…
View article: Saliva or Nasopharyngeal Swab Specimens for Detection of SARS-CoV-2
Saliva or Nasopharyngeal Swab Specimens for Detection of SARS-CoV-2 Open
In this letter, the investigators report that saliva specimens and nasopharyngeal swab specimens had similar sensitivity in the detection of SARS-CoV-2 RNA in both symptomatic and asymptomatic persons.
View article: Analytical sensitivity and efficiency comparisons of SARS-CoV-2 RT–qPCR primer–probe sets
Analytical sensitivity and efficiency comparisons of SARS-CoV-2 RT–qPCR primer–probe sets Open
View article: Neuroinvasion of SARS-CoV-2 in human and mouse brain
Neuroinvasion of SARS-CoV-2 in human and mouse brain Open
Summary Although COVID-19 is considered to be primarily a respiratory disease, SARS-CoV-2 affects multiple organ systems including the central nervous system (CNS). Yet, there is no consensus whether the virus can infect the brain, or what…
View article: IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy
IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy Open
View article: Saliva is more sensitive for SARS-CoV-2 detection in COVID-19 patients than nasopharyngeal swabs
Saliva is more sensitive for SARS-CoV-2 detection in COVID-19 patients than nasopharyngeal swabs Open
Rapid and accurate SARS-CoV-2 diagnostic testing is essential for controlling the ongoing COVID-19 pandemic. The current gold standard for COVID-19 diagnosis is real-time RT-PCR detection of SARS-CoV-2 from nasopharyngeal swabs. Low sensit…
View article: Analytical sensitivity and efficiency comparisons of SARS-COV-2 qRT-PCR primer-probe sets
Analytical sensitivity and efficiency comparisons of SARS-COV-2 qRT-PCR primer-probe sets Open
The recent spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exemplifies the critical need for accurate and rapid diagnostic assays to prompt clinical and public health interventions. Currently, several quantitative re…
View article: Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12
Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12 Open
View article: Cytomegalovirus Infection Drives Avidity Selection of Natural Killer Cells
Cytomegalovirus Infection Drives Avidity Selection of Natural Killer Cells Open
View article: Epigenetic control of innate and adaptive immune memory
Epigenetic control of innate and adaptive immune memory Open
View article: Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer Cell Response
Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer Cell Response Open
View article: Core-binding factor β and Runx transcription factors promote adaptive natural killer cell responses
Core-binding factor β and Runx transcription factors promote adaptive natural killer cell responses Open
Runx1 and Runx3 play nonredundant roles in promoting the clonal expansion of NK cells during viral infection.
View article: ILC1 Confer Early Host Protection at Initial Sites of Viral Infection
ILC1 Confer Early Host Protection at Initial Sites of Viral Infection Open
View article: Epitope-Specific Vaccination Limits Clonal Expansion of Heterologous Naive T Cells during Viral Challenge
Epitope-Specific Vaccination Limits Clonal Expansion of Heterologous Naive T Cells during Viral Challenge Open
Despite robust secondary T cell expansion primed by vaccination, the impact on primary immune responses to heterotypic antigens remains undefined. Here we show that secondary expansion of epitope-specific memory CD8+ T cells primed by prio…
View article: Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance
Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance Open
View article: Atg5 Is Essential for the Development and Survival of Innate Lymphocytes
Atg5 Is Essential for the Development and Survival of Innate Lymphocytes Open
Autophagy is an essential cellular survival mechanism that is required for adaptive lymphocyte development; however, its role in innate lymphoid cell (ILC) development remains unknown. Furthermore, the conditions that promote lymphocyte au…