Osama Hasan Mustafa Hasan Abdalla
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View article: Cuticular hydrocarbons promote desiccation resistance by preventing transpiration in <i>Drosophila melanogaster</i>
Cuticular hydrocarbons promote desiccation resistance by preventing transpiration in <i>Drosophila melanogaster</i> Open
Desiccation is a fundamental challenge confronted by all terrestrial organisms, particularly insects. With a relatively small body size and large surface-to-volume ratio, insects are susceptible to rapid evaporative water loss and dehydrat…
View article: Mitochondrial dysfunction reactivates α-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models
Mitochondrial dysfunction reactivates α-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models Open
Signaling circuits crucial to systemic physiology are widespread, yet uncovering their molecular underpinnings remains a barrier to understanding the etiology of many metabolic disorders. Here, we identified a copper-linked signaling circu…
View article: Death of a Protein: The Role of E3 Ubiquitin Ligases in Circadian Rhythms of Mice and Flies
Death of a Protein: The Role of E3 Ubiquitin Ligases in Circadian Rhythms of Mice and Flies Open
Circadian clocks evolved to enable organisms to anticipate and prepare for periodic environmental changes driven by the day–night cycle. This internal timekeeping mechanism is built on autoregulatory transcription–translation feedback loop…
View article: SOX2 Regulates Neuronal Differentiation of the Suprachiasmatic Nucleus
SOX2 Regulates Neuronal Differentiation of the Suprachiasmatic Nucleus Open
In mammals, the hypothalamic suprachiasmatic nucleus (SCN) functions as the central circadian pacemaker, orchestrating behavioral and physiological rhythms in alignment to the environmental light/dark cycle. The neurons that comprise the S…