Osama Saher
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View article: Revolutionary hyaluronic acid-modified edge-activated spanlastics as a novel approach to boost Hepatoprotective activity of Curcumin: Optimization, biochemical analysis and in-vivo assessment
Revolutionary hyaluronic acid-modified edge-activated spanlastics as a novel approach to boost Hepatoprotective activity of Curcumin: Optimization, biochemical analysis and in-vivo assessment Open
View article: Novel hybrid tri-polymer hyalurosomes: unlocking next-generation trans-tympanic therapeutics through multi-Scale evaluations
Novel hybrid tri-polymer hyalurosomes: unlocking next-generation trans-tympanic therapeutics through multi-Scale evaluations Open
View article: Advanced peptide nanoparticles enable robust and efficient delivery of gene editors across cell types
Advanced peptide nanoparticles enable robust and efficient delivery of gene editors across cell types Open
Efficient delivery of the CRISPR/Cas9 system and its larger derivatives, base editors, and prime editors remain a major challenge, particularly in tissue-specific stem cells and induced pluripotent stem cells (iPSCs). This study optimized …
View article: Development and characterization of fenticonazole nitrate-loaded cubogel for the management of vaginal candidiasis
Development and characterization of fenticonazole nitrate-loaded cubogel for the management of vaginal candidiasis Open
Vaginal candidiasis is a medical condition that affects large majority of the women at least once in their lifetime. The condition manifests with itching, irritation, and discharges which is troublesome for women during mundane activities.…
View article: Anti-gene oligonucleotides targeting Friedreich’s ataxia expanded GAA⋅TTC repeats increase Frataxin expression
Anti-gene oligonucleotides targeting Friedreich’s ataxia expanded GAA⋅TTC repeats increase Frataxin expression Open
View article: Advanced Peptide Nanoparticles Enable Robust and Efficient delivery of gene editors across cell types
Advanced Peptide Nanoparticles Enable Robust and Efficient delivery of gene editors across cell types Open
Efficient delivery of the CRISPR/Cas9 system and its larger derivatives, base editors, and prime editors remain a significant challenge, particularly in tissue-specific stem cells and induced pluripotent stem cells (iPSCs). This study opti…
View article: Augmented glycerosomes as a promising approach against fungal ear infection: Optimization and microbiological, ex vivo and in vivo assessments
Augmented glycerosomes as a promising approach against fungal ear infection: Optimization and microbiological, ex vivo and in vivo assessments Open
In the current study, voriconazole (VCZ) augmented glycerosomes were optimized for topical otomycosis management according to a 23 factorial design, employing a thin film hydration method. By optimizing Glycerol volume, limonene…
View article: Tumor cell derived osteopontin and prostaglandin E2 synergistically promote the expansion of myeloid derived suppressor cells during the tumor immune escape phase
Tumor cell derived osteopontin and prostaglandin E2 synergistically promote the expansion of myeloid derived suppressor cells during the tumor immune escape phase Open
The immune escape stage in cancer immunoediting is a pivotal feature, transitioning immune-controlled tumor dormancy to progression, and augmenting invasion and metastasis. Tumors employ diverse mechanisms for immune escape, with generatin…
View article: Anti-gene oligonucleotides targeting Friedreich’s ataxia expanded GAA•TTC repeats increase Frataxin expression
Anti-gene oligonucleotides targeting Friedreich’s ataxia expanded GAA•TTC repeats increase Frataxin expression Open
Friedreich’s ataxia (FRDA) is a progressive, autosomal recessive ataxia caused, in the majority of cases, by homozygous expansion of GAA•TTC triplet-repeats in the first intron of the frataxin ( FXN ) gene. GAA•TTC repeat expansion results…
View article: The cellular response to extracellular vesicles is dependent on their cell source and dose
The cellular response to extracellular vesicles is dependent on their cell source and dose Open
Extracellular vesicles (EVs) have been established to play important roles in cell-cell communication and shown promise as therapeutic agents. However, we still lack a basic understanding of how cells respond upon exposure to EVs from diff…
View article: Chemical Modifications and Design Influence the Potency of <i>Huntingtin</i> Anti-Gene Oligonucleotides
Chemical Modifications and Design Influence the Potency of <i>Huntingtin</i> Anti-Gene Oligonucleotides Open
Huntington's disease is a neurodegenerative, trinucleotide repeat (TNR) disorder affecting both males and females. It is caused by an abnormal increase in the length of CAG•CTG TNR in exon 1 of the Huntingtin gene (HTT). The …
View article: SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion
SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion Open
The corona virus (SARS-CoV-2) pandemic and the resulting long-term neurological complications in patients, known as long COVID, have renewed the interest in the correlation between viral infections and neurodegenerative brain disorders. Wh…
View article: Novel endosomolytic compounds enable highly potent delivery of antisense oligonucleotides
Novel endosomolytic compounds enable highly potent delivery of antisense oligonucleotides Open
The therapeutic and research potentials of oligonucleotides (ONs) have been hampered in part by their inability to effectively escape endosomal compartments to reach their cytosolic and nuclear targets. Splice-switching ONs (SSOs) can be u…
View article: Growth Media Conditions Influence the Secretion Route and Release Levels of Engineered Extracellular Vesicles
Growth Media Conditions Influence the Secretion Route and Release Levels of Engineered Extracellular Vesicles Open
Extracellular vesicles (EVs) are nanosized cell‐derived vesicles produced by all cells, which provide a route of intercellular communication by transmitting biological cargo. While EVs offer promise as therapeutic agents, the molecular mec…
View article: Oligonucleotides Targeting DNA Repeats Downregulate <i>Huntingtin</i> Gene Expression in Huntington's Patient-Derived Neural Model System
Oligonucleotides Targeting DNA Repeats Downregulate <i>Huntingtin</i> Gene Expression in Huntington's Patient-Derived Neural Model System Open
Huntington's disease (HD) is one of the most common, dominantly inherited neurodegenerative disorders. It affects the striatum, cerebral cortex, and other subcortical structures leading to involuntary movement abnormalities, emotional dist…
View article: Novel Orthogonally Hydrocarbon-Modified Cell-Penetrating Peptide Nanoparticles Mediate Efficient Delivery of Splice-Switching Antisense Oligonucleotides In Vitro and In Vivo
Novel Orthogonally Hydrocarbon-Modified Cell-Penetrating Peptide Nanoparticles Mediate Efficient Delivery of Splice-Switching Antisense Oligonucleotides In Vitro and In Vivo Open
Splice-switching therapy with splice-switching oligonucleotides (SSOs) has recently proven to be a clinically applicable strategy for the treatment of several mis-splice disorders. Despite this, wider application of SSOs is severely limite…
View article: Lipophilic Peptide Dendrimers for Delivery of Splice-Switching Oligonucleotides
Lipophilic Peptide Dendrimers for Delivery of Splice-Switching Oligonucleotides Open
Non-viral transfection reagents are continuously being developed in attempt to replace viral vectors. Among those non-viral vectors, dendrimers have gained increasing interest due to their unique molecular structure and multivalency. Howev…
View article: Quantification of extracellular vesicles <i>in vitro</i> and <i>in vivo</i> using sensitive bioluminescence imaging
Quantification of extracellular vesicles <i>in vitro</i> and <i>in vivo</i> using sensitive bioluminescence imaging Open
Extracellular vesicles (EVs) are naturally occurring nano-sized carriers that are secreted by cells and facilitate cell-to-cell communication by their unique ability to transfer biologically active cargo. Despite the pronounced increase in…
View article: Novel mouse model resistant to irreversible BTK inhibitors: a tool identifying new therapeutic targets and side effects
Novel mouse model resistant to irreversible BTK inhibitors: a tool identifying new therapeutic targets and side effects Open
Pharmacological inhibitors of Bruton tyrosine kinase (BTK) have revolutionized treatment of B-lymphocyte malignancies and show great promise for dampening autoimmunity. The predominant BTK inhibitors tether irreversibly by covalently bindi…
View article: Sugar and Polymer Excipients Enhance Uptake and Splice-Switching Activity of Peptide-Dendrimer/Lipid/Oligonucleotide Formulations
Sugar and Polymer Excipients Enhance Uptake and Splice-Switching Activity of Peptide-Dendrimer/Lipid/Oligonucleotide Formulations Open
Non-viral transfection vectors are commonly used for oligonucleotide (ON) delivery but face many challenges before reaching the desired compartments inside cells. With the support of additional compounds, it might be more feasible for a ve…
View article: The viral protein corona directs viral pathogenesis and amyloid aggregation
The viral protein corona directs viral pathogenesis and amyloid aggregation Open
View article: Oligonucleotide–Palladacycle Conjugates as Splice-Correcting Agents
Oligonucleotide–Palladacycle Conjugates as Splice-Correcting Agents Open
2’-O-Methylribo phosphorothioate oligonucleotides incorporating cyclopalladated benzylamine conjugate groups at their 5’-termini have been prepared and their ability to hybridize with a designated target sequence was assessed by convention…
View article: Novel peptide-dendrimer/lipid/oligonucleotide ternary complexes for efficient cellular uptake and improved splice-switching activity
Novel peptide-dendrimer/lipid/oligonucleotide ternary complexes for efficient cellular uptake and improved splice-switching activity Open
View article: The Viral Protein Corona Directs Viral Pathogenesis and Amyloid Aggregation
The Viral Protein Corona Directs Viral Pathogenesis and Amyloid Aggregation Open
Artificial nanoparticles accumulate a protein corona layer in biological fluids, which significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses share many biophysical properties with artificial nan…