Muhammad Osama
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View article: Cumulative Hepatoprotective, Antihyperlipidemic and Antioxidant Effects of Methanolic Seeds Extract of <scp> <i>Citrullus lanatus</i> </scp> , <scp> <i>Cucumis melo</i> </scp> , <scp> <i>Cucumis sativus</i> </scp> , and <scp> <i>Cucurbita maxima</i> </scp> With <scp>GC</scp> – <scp>MS</scp> Profile
Cumulative Hepatoprotective, Antihyperlipidemic and Antioxidant Effects of Methanolic Seeds Extract of <span> <i>Citrullus lanatus</i> </span> , <span> <i>Cucumis melo</i> </span> , <span> <i>Cucumis sativus</i> </span> , and <span> <i>Cucurbita maxima</i> </span> With <span>GC</span> – <span>MS</span> Profile Open
The complex pathophysiological mechanism of nonalcoholic fatty liver (NAFLD) disease has made the prevention and treatment of the disease problematic. The aim of the current study is to evaluate the cumulative hepatoprotective, antihyperli…
View article: Analysis of Demographic Associations and Survival Outcomes in Patients With Colorectal Cancer at a Tertiary Care Hospital in Pakistan. A Retrospective Cross-Sectional Study
Analysis of Demographic Associations and Survival Outcomes in Patients With Colorectal Cancer at a Tertiary Care Hospital in Pakistan. A Retrospective Cross-Sectional Study Open
Introduction Colorectal cancer (CRC) is the third most common cancer worldwide, with higher rates in industrialized countries. By 2030, the number of CRC cases may rise by 60%, reaching 2.2 million new cases and 1.1 million deaths. In 2020…
View article: Real world efficacy of omalizumab in reducing surgical intervention for nasal polyps in Samter’s triad
Real world efficacy of omalizumab in reducing surgical intervention for nasal polyps in Samter’s triad Open
The advancements in the field of medicine, particularly in the field of drug application, has told us that Omalizumab has a significant impact on the management of nasal polyps, especially in the context of Samter’s triad. Our letter highl…
View article: Hypoplastic Internal Carotid Artery in a Young Stroke Patient
Hypoplastic Internal Carotid Artery in a Young Stroke Patient Open
Background: Hypoplastic internal carotid artery (HICA) is a rare congenital vascular anomaly, typically asymptomatic due to collateral circulation. However, in certain cases, it may present with ischemic stroke. Case Presentation: We repor…
View article: Unearthing novel PPAR-γ activators: In silico design of eucalyptolanalogues for ulcerative colitis
Unearthing novel PPAR-γ activators: In silico design of eucalyptolanalogues for ulcerative colitis Open
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with rising prevalence, necessitating novel therapeutics. The peroxisome proliferator-activated receptor gamma (PPAR-γ) is a promising target for UC management. This study aim…
View article: Microbiological Spectrum and Antibiotics Sensitivity Pattern of Chronic Suppurative Otitis Media (CSOM) Patients: A prospective study from a Tertiary Care Hospital in Peshawar
Microbiological Spectrum and Antibiotics Sensitivity Pattern of Chronic Suppurative Otitis Media (CSOM) Patients: A prospective study from a Tertiary Care Hospital in Peshawar Open
Background & Objective: Chronic suppurative otitis media is a fatal condition owing to its propensity for intracranial extension. The inadvertent use of antibiotics has led to resistance among causative organisms. The objectives of this st…
View article: Urinary Tract Microbiome Association with Diseases and Autoimmunity: Plausible Potential for Therapeutics and Accompanying Challenges
Urinary Tract Microbiome Association with Diseases and Autoimmunity: Plausible Potential for Therapeutics and Accompanying Challenges Open
The urinary tract, once considered sterile, is now understood to host a diverse community of microorganisms known as the urinary microbiome. This microbiome, which is made up of bacteria, fungi, and viruses, is important for preserving uro…
View article: BARRIERS TO INITIATE INSULIN THERAPY AND ITS ASSOCIATION WITH DURATION OF DIABETES MELITIS AND DEMOGRAPHIC FACTORS IN UNCONTROLLED TYPE 2 DIABETIC PATIENTS, A CROSS SECTIONAL STUDY
BARRIERS TO INITIATE INSULIN THERAPY AND ITS ASSOCIATION WITH DURATION OF DIABETES MELITIS AND DEMOGRAPHIC FACTORS IN UNCONTROLLED TYPE 2 DIABETIC PATIENTS, A CROSS SECTIONAL STUDY Open
Objectives: To determine different barriers to initiate insulin therapy and association of duration of diabetes mellitus and demographic factors with barriers in initiation of insulin therapy in Uncontrolled type 2 diabetic patients.Materi…
View article: AN UPDATE ON CURRENT STATUS OF ANTIBIOTIC RESISTANCE IN SALMONELLA TYPHI: A RETROSPECTIVE ANALYSIS OF BLOOD CULTURE REPORTS FROM A TERTIARY CARE HOSPITAL
AN UPDATE ON CURRENT STATUS OF ANTIBIOTIC RESISTANCE IN SALMONELLA TYPHI: A RETROSPECTIVE ANALYSIS OF BLOOD CULTURE REPORTS FROM A TERTIARY CARE HOSPITAL Open
Background: Pakistan bears most of the burden of drug-resistant typhoid, challenging its healthcare systems with substantial cost. This study’s purpose is to investigate resistance in community-acquired salmonella typhi to guide its eviden…
View article: Stream-K++: Adaptive GPU GEMM Kernel Scheduling and Selection using Bloom Filters
Stream-K++: Adaptive GPU GEMM Kernel Scheduling and Selection using Bloom Filters Open
General matrix multiplication (GEMM) operations are the fundamental building blocks of computational domains including artificial intelligence (AI). As GPU architectures evolve and high-performance AI becomes increasingly important, optimi…
View article: Estimation of Anxiolytic Efficacy of Carica Papaya L. Seeds using Experimental Animal Models of Anxiety
Estimation of Anxiolytic Efficacy of Carica Papaya L. Seeds using Experimental Animal Models of Anxiety Open
Background: Natural remedies have garnered global recognition for their therapeutic applications, supported by their unique nutritional and bioactive compositions. Among these, Carica papaya L., commonly known as papaya, has been historica…
View article: Emerging antibiotic resistance profiles in urinary tract infections among the elderly
Emerging antibiotic resistance profiles in urinary tract infections among the elderly Open
Antibiotic resistance is an increasing danger to treating UTIs in aging patients. These assessments found a regarding raise in multidrug-resistant bacteria those making old-style antibiotics less effective. The weakened immune systems, num…
View article: Mitigation of Organ Specific Toxicity FollowingAcute Dinotefuran Exposure throughVitamin C Supplementation
Mitigation of Organ Specific Toxicity FollowingAcute Dinotefuran Exposure throughVitamin C Supplementation Open
The objective of this research was to assess the impact of 2-methyl-2-nitro-3-guanidine on mammalian species, otherwise not the intended targets, followed by one-time exposure and its adverse effects.Thirty-five Sprague Dawley rats of eith…
View article: A Systematic Review To Unveil Therapeutic Potential Of Some Common Green Seaweeds
A Systematic Review To Unveil Therapeutic Potential Of Some Common Green Seaweeds Open
The increasing demand of mankind for a healthier life and increased longevity has led humans to consume functional foods with plenteous sources of biochemical compounds and other nutraceuticals. Among these famous natural resources, seawee…
View article: Prevalence Of Measles In Vaccinated And Unvaccinated Children In QHAMC, Nowshera.
Prevalence Of Measles In Vaccinated And Unvaccinated Children In QHAMC, Nowshera. Open
Objective: Measles is an infectious disease that is a prodigious threat to mortality under 5. This cross-sectional study was conducted to determine the prevalence of measles vaccination and its effectiveness. Study design: A Cross-Sectiona…
View article: Long Term Outcome of Percutaneous Coronary Intervention in Patients with Unprotected Left Main Disease
Long Term Outcome of Percutaneous Coronary Intervention in Patients with Unprotected Left Main Disease Open
Background: The management of unprotected left main coronary artery disease (LM CAD) poses a significant clinical challenge. Percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) have been extensively compared…
View article: Prevalence of Oral Allergy Syndrome among Adults with Prevalence and Linkages with Various Factors
Prevalence of Oral Allergy Syndrome among Adults with Prevalence and Linkages with Various Factors Open
Background: Oral allergy syndrome is the most common manifestation of food allergies in adults. However, population-based studies assessing its prevalence and associated factors remain limited in Pakistan. Objective: To determine the preva…
View article: Comparative IgG Antibody Titers Following Second Dose of Sinopharm and Pfizer Vaccination
Comparative IgG Antibody Titers Following Second Dose of Sinopharm and Pfizer Vaccination Open
Background and Objective: The vaccines Sinopharm and Pfizer account for more than 7.3 billion vaccinations across the globe. Study data shows that the protection offered by these vaccines wanes with time, which is why the third dose of a d…
View article: Supplementary (MD): Repurposing Alzheimer's Therapeutics: A Computational Approach to Identifying Potential SARS-CoV-2 Mpro Inhibitors
Supplementary (MD): Repurposing Alzheimer's Therapeutics: A Computational Approach to Identifying Potential SARS-CoV-2 Mpro Inhibitors Open
100 ns Molecular Dynamic Simulation Trajectories for Compound 2, 3, 6, 7, and 8
View article: Supplementary (MD): Repurposing Alzheimer's Therapeutics: A Computational Approach to Identifying Potential SARS-CoV-2 Mpro Inhibitors
Supplementary (MD): Repurposing Alzheimer's Therapeutics: A Computational Approach to Identifying Potential SARS-CoV-2 Mpro Inhibitors Open
100 ns Molecular Dynamic Simulation Trajectories for Compound 2, 3, 6, 7, and 8
View article: MINOCA - A Rarity Of It's Own And The Importance Of Cardiac MRI
MINOCA - A Rarity Of It's Own And The Importance Of Cardiac MRI Open
Myocardial infarction with non-obstructive coronary arteries (MINOCA) disease is a diagnostic dilemma with clinical evidence of acute myocardial infarction (AMI) with normal coronary arteries. MINOCA is a complex issue; the management of t…
View article: A COMPREHENSIVE REVIEW OF UTERINE FIBROIDS: PATHOGENESIS, DIAGNOSIS, TREATMENT, AND FUTURE PERSPECTIVES
A COMPREHENSIVE REVIEW OF UTERINE FIBROIDS: PATHOGENESIS, DIAGNOSIS, TREATMENT, AND FUTURE PERSPECTIVES Open
Fibroid, myoma, and leiomyoma are interchangeable terms used to describe the most common gynecological tumors, which are benign neoplasms originating in the smooth muscles of the uterus. These tumors are a leading cause of hysterectomies. …
View article: REVISITING THE SARS-COV-2 MAIN PROTEASE: A 2023 IN SILICO ODYSSEY IN SEARCH OF POTENTIAL INHIBITORS
REVISITING THE SARS-COV-2 MAIN PROTEASE: A 2023 IN SILICO ODYSSEY IN SEARCH OF POTENTIAL INHIBITORS Open
The novel coronavirus disease or Covid-19 is a global pandemic caused by the SARS-CoV-2 virus originated from Wuhan, China in December 2019. A rapidly spreading, contagious virus that caused more than 6.7 million deaths worldwide. The main…
View article: Hydroxychloroquine Induced Cardiomyopathy
Hydroxychloroquine Induced Cardiomyopathy Open
Hydroxychloroquine (HCQ) is one of the immunomodulatory medications used in treatment of autoimmune diseases. Rarely, HCQ can cause serious complications, such as cardiotoxicity. We present a rare case of HCQ-induced cardiomyopathy. 60-yea…
View article: Implications of different irrigation water qualities on crop production: A case study of Sharkia Governorate
Implications of different irrigation water qualities on crop production: A case study of Sharkia Governorate Open
This work aims to study the invasion of environmental pollutants from the irrigation water to the soil. To achieve this goal, three irrigated areas (at the same Zane) were selected. The first area is irrigated with fresh water; the second …
View article: ASSESSMENT OF MORPHOLOGICAL TRAITS IN TOMATO HYBRIDS FOR IMPROVED CULTIVATION PRACTICES
ASSESSMENT OF MORPHOLOGICAL TRAITS IN TOMATO HYBRIDS FOR IMPROVED CULTIVATION PRACTICES Open
Tomato is widely used as a vegetable and plays an important role in the diet for its health benefits. The present research was carried out at the vegetable section of Barani Agricultural Research Institute (BARI), Chakwal, Pakistan, during…
View article: B-3 | Cardiovascular Outcomes of Redo-Coronary Artery Bypass Graft Versus Percutaneous Coronary Intervention of Index Bypass Grafts Among Acute Coronary Syndrome: Regression Matched National Cohort Study
B-3 | Cardiovascular Outcomes of Redo-Coronary Artery Bypass Graft Versus Percutaneous Coronary Intervention of Index Bypass Grafts Among Acute Coronary Syndrome: Regression Matched National Cohort Study Open
Procedural and hospital outcomes of PCI versus CABG among ACS patients with prior history of CABG remains understudied. Percutaneous coronary intervention (PCI) and Coronary artery bypass grafting (CABG) formed the two comparison cohorts. …