Osamu Morinaga
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View article: Locomotor-Reducing, Sedative, and Antidepressant-Like Effects of Confectionery Flavours Coumarin and Vanillin
Locomotor-Reducing, Sedative, and Antidepressant-Like Effects of Confectionery Flavours Coumarin and Vanillin Open
Coumarin and vanillin are compounds with comforting scents and are often used for flavouring confectionery. The locomotor-reducing, sedative, and antidepressant-like effects of coumarin and vanillin vapours administered via inhalation were…
View article: Corrigendum: Identification of an alternative glycyrrhizin metabolite causing liquorice-induced pseudohyperaldosteronism and the development of ELISA system to detect the predictive biomarker
Corrigendum: Identification of an alternative glycyrrhizin metabolite causing liquorice-induced pseudohyperaldosteronism and the development of ELISA system to detect the predictive biomarker Open
[This corrects the article DOI: 10.3389/fphar.2021.688508.].
View article: Evaluation of the Amounts of Sennosides A and B in Rhubarb-containing Kampo Medicines to Create a Ranking of Kampo Medicines for Appropriate Selection of Laxatives
Evaluation of the Amounts of Sennosides A and B in Rhubarb-containing Kampo Medicines to Create a Ranking of Kampo Medicines for Appropriate Selection of Laxatives Open
These results suggest that the differences in amounts of sennosides are caused by the quality of the rhubarb used. Kampo medicines containing laxatives other than rhubarb, including disodium sulphate and hemp seed, had synergistic laxative…
View article: Identification of an Alternative Glycyrrhizin Metabolite Causing Liquorice-Induced Pseudohyperaldosteronism and the Development of ELISA System to Detect the Predictive Biomarker
Identification of an Alternative Glycyrrhizin Metabolite Causing Liquorice-Induced Pseudohyperaldosteronism and the Development of ELISA System to Detect the Predictive Biomarker Open
Liquorice is usually used as crude drug in traditional Japanese Kampo medicine and traditional Chinese medicine. Liquorice-containing glycyrrhizin (GL) can cause pseudohyperaldosteronism as a side effect. Previously, we identified 18 β -gl…
View article: Non-surgical Treatment of Anal Fissures: Standard and State-of-the-art Treatment
Non-surgical Treatment of Anal Fissures: Standard and State-of-the-art Treatment Open
裂肛の治療には保存的（＝非手術的）治療と手術的治療がある．保存的治療には，生活指導，外用薬物治療，排便コントロール，局所用硝酸塩，カルシウムチャネルブロッカー，ボツリヌス毒素によるものがある．本稿ではこれらについて概説する．最先端の治療としては，新機序の慢性便秘症治療薬によるもの，カルシウムチャネルブロッカーによる化学的括約筋切開について，本邦の動きも含めて記載する．保存的治療は手術的治療の前段階として考えられがちであるが，手術的治療後の状態維持，再発予防にも関係するので，…
View article: Scientific Evaluation of Crude Drugs and Kampo Medicines Using the Eastern Blotting Method and Its Application to Biological Metabolic Studies
Scientific Evaluation of Crude Drugs and Kampo Medicines Using the Eastern Blotting Method and Its Application to Biological Metabolic Studies Open
The scientific evaluation of crude drugs and kampo medicines (KMs) was demonstrated using the eastern blotting method with monoclonal antibodies (MAbs) against bioactive natural compounds. Scutellariae radix is one of the most important cr…
View article: Ophiocordyceps pulvinata Induces Caspase-Dependent Apoptosis through Mitochondrial Impairment in Human Leukemia Cells
Ophiocordyceps pulvinata Induces Caspase-Dependent Apoptosis through Mitochondrial Impairment in Human Leukemia Cells Open
Cordyceps is a genus of fungi from the Cordycipitaceae family that grows using host insects as the nutritional source. This genus comprises approximately 500 species worldwide. In the present study, culturing 16 species from 3 genuses of C…
View article: In vitro anti-Leishmania activity of tetracyclic iridoids from Morinda lucida, benth
In vitro anti-Leishmania activity of tetracyclic iridoids from Morinda lucida, benth Open
Leishmaniasis is an infectious disease transmitted by the sand fly. It is caused by over 20 different species of Leishmania and has affected over 14 million people worldwide. One of the main forms of control of leishmaniasis is chemotherap…
View article: Antitrypanosomal Activities and Mechanisms of Action of Novel Tetracyclic Iridoids from Morinda lucida Benth
Antitrypanosomal Activities and Mechanisms of Action of Novel Tetracyclic Iridoids from Morinda lucida Benth Open
Trypanosoma brucei parasites are kinetoplastid protozoa that devastate the health and economic well-being of millions of people in Africa through the disease human African trypanosomiasis (HAT). New chemotherapy has been eagerly awaited du…
View article: <b>Triterpenes suppress octanoylated ghrelin production in ghrelin-expressing human gastric carcinoma </b><b>cells </b>
<b>Triterpenes suppress octanoylated ghrelin production in ghrelin-expressing human gastric carcinoma </b><b>cells </b> Open
Ghrelin is an appetite-stimulating peptide hormone with an octanoyl modification at serine 3 that is essential for its orexigenic effect. Ghrelin O-acyltransferase (GOAT) is the enzyme that catalyzes ghrelin acylation using fatty acyl-coen…