Oscar Delaney
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View article: In Which Areas of Technical AI Safety Could Geopolitical Rivals Cooperate?
In Which Areas of Technical AI Safety Could Geopolitical Rivals Cooperate? Open
View article: Optimal antimicrobial dosing combinations when drug-resistance mutation rates differ
Optimal antimicrobial dosing combinations when drug-resistance mutation rates differ Open
Given the ongoing antimicrobial resistance crisis, it is imperative to develop dosing regimens optimized to avoid the evolution of resistance. The rate at which bacteria acquire resistance-conferring mutations to different antimicrobial dr…
View article: Optimal antimicrobial dosing combinations when drug-resistance mutation rates differ
Optimal antimicrobial dosing combinations when drug-resistance mutation rates differ Open
Given the ongoing antimicrobial resistance crisis, it is imperative to develop dosing regimens optimised to avoid the evolution of resistance. The rate at which bacteria acquire resistance-conferring mutations to different antimicrobial dr…
View article: Drug mode of action and resource constraints modulate antimicrobial resistance evolution
Drug mode of action and resource constraints modulate antimicrobial resistance evolution Open
One of the key characteristics of an antibiotic drug is its mode of action: bacteriostatic or bactericidal. The effect of drug mode of action on the evolution of resistance has been surprisingly underinvestigated to date. We present a theo…
View article: Frequent, infinitesimal bottlenecks maximize the rate of microbial adaptation
Frequent, infinitesimal bottlenecks maximize the rate of microbial adaptation Open
Serial passaging is a fundamental technique in experimental evolution. The choice of bottleneck severity and frequency poses a dilemma: longer growth periods allow beneficial mutants to arise and grow over more generations, but simultaneou…
View article: Deploying Digital Detection of Dangerous DNA
Deploying Digital Detection of Dangerous DNA Open
Ready access to synthetic DNA has enabled vast progress in health and biotechnology in recent decades. However, it also makes it easier for malicious actors to develop biological weapons that threaten public health. Thus, it is crucial to …
View article: Multimedia design for learning: An overview of reviews with meta-meta-analysis
Multimedia design for learning: An overview of reviews with meta-meta-analysis Open
Multimedia is ubiquitous in 21st-century education. Cognitive Load Theory and the Cognitive Theory of Multimedia Learning both postulate that the quality of multimedia design heavily influences learning. We sought to identify how to best d…
View article: Video improves learning in higher education: A systematic review
Video improves learning in higher education: A systematic review Open
Universities around the world are incorporating online learning, often relying upon videos (asynchronous multimedia). We systematically reviewed the effects of video on learning in higher education. We searched five databases using 27 keyw…