Óscar Medina‐Contreras
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View article: Sea Cucumber (Isostichopus badionotus): Bioactivity and Wound Healing Capacity In Vitro of Small Peptide Isolates from Digests of Whole-Body Wall or Purified Collagen
Sea Cucumber (Isostichopus badionotus): Bioactivity and Wound Healing Capacity In Vitro of Small Peptide Isolates from Digests of Whole-Body Wall or Purified Collagen Open
Low-molecular-weight peptides derived from the digestion of body wall proteins in some sea cucumber species have wound-healing and health-promoting properties, but their potency varies widely by species, growth environment, age, and season…
View article: The Role of Inflammasomes in LPS and Gram-Negative Bacterial Sepsis
The Role of Inflammasomes in LPS and Gram-Negative Bacterial Sepsis Open
Background/Objectives: Sepsis is a life-threatening condition characterized by an uncontrolled immune response due to systemic infections. It is responsible for millions of deaths worldwide. Although inflammasomes play an important role in…
View article: Sea Cucumber (<em>Isostichopus badionotus</em>): Bioactivity and Wound Healing Capacity In Vitro of Small Peptide Isolates from Digests of Whole-Body Wall or Purified Collagen
Sea Cucumber (<em>Isostichopus badionotus</em>): Bioactivity and Wound Healing Capacity In Vitro of Small Peptide Isolates from Digests of Whole-Body Wall or Purified Collagen Open
Low-molecular-weight peptides derived by digestion of body wall proteins from some sea cucumber species have wound-healing and health-promoting properties. Sea cucumber body composition varies widely by species, growth environment, age and…
View article: HPV vaccination improves immune response in children with respiratory papillomatosis
HPV vaccination improves immune response in children with respiratory papillomatosis Open
View article: Isthmin1 Upregulation in the Intestinal Microenvironment During Salmonella Typhimurium Infection: Identification and Characterization of Isthmin1-Producing Cells
Isthmin1 Upregulation in the Intestinal Microenvironment During Salmonella Typhimurium Infection: Identification and Characterization of Isthmin1-Producing Cells Open
Isthmin1 (ISM1) is a constitutively secreted cytokine produced by barrier tissues and different immune cell types. Importantly, ISM1 is also expressed by cells with a hematopoietic stem cell phenotype in the lung and plays a role during he…
View article: A Lambda-evo (λevo) phage platform for Zika virus EDIII protein display
A Lambda-evo (λevo) phage platform for Zika virus EDIII protein display Open
One of the most significant bacteriophage technologies is phage display, in which heterologous peptides are exhibited on the virion surface. This work describes the display of λ decorative protein D λ linked to the E protein domain III of …
View article: Editorial: Cervical cancer: updates from the Mexican national consensus
Editorial: Cervical cancer: updates from the Mexican national consensus Open
View article: UNAM-HIMFG Bacterial Lysate Activates the Immune Response and Inhibits Colonization of Bladder of Balb/c Mice Infected with the Uropathogenic CFT073 Escherichia coli Strain
UNAM-HIMFG Bacterial Lysate Activates the Immune Response and Inhibits Colonization of Bladder of Balb/c Mice Infected with the Uropathogenic CFT073 Escherichia coli Strain Open
Urinary tract infections (UTIs) represent a clinical and epidemiological problem of worldwide impact that affects the economy and the emotional state of the patient. Control of the condition is complicated due to multidrug resistance of pa…
View article: Tumor-Suppressive Cross-Linking of Anti-T. cruzi Antibodies in Acute Lymphoblastic Leukemia
Tumor-Suppressive Cross-Linking of Anti-T. cruzi Antibodies in Acute Lymphoblastic Leukemia Open
Parasites have been associated with possible anticancer activity, including Trypanosoma cruzi, which has been linked to inhibiting the growth of solid tumors. To better understand this antitumor effect, we investigated the association of a…
View article: IFN‐γ stimulates Paneth cell secretion through necroptosis mTORC1 dependent
IFN‐γ stimulates Paneth cell secretion through necroptosis mTORC1 dependent Open
Immune mediators affect multiple biological functions of intestinal epithelial cells (IECs) and, like Paneth and Paneth‐like cells, play an important role in intestinal epithelial homeostasis. IFN‐γ a prototypical proinflammatory cytokine …
View article: Polyvalent Bacterial Lysate with Potential Use to Treatment and Control of Recurrent Urinary Tract Infections
Polyvalent Bacterial Lysate with Potential Use to Treatment and Control of Recurrent Urinary Tract Infections Open
Overuse of antimicrobials has greatly contributed to the increase in the emergence of multidrug-resistant bacteria, a situation that hinders the control and treatment of infectious diseases. This is the case with urinary tract infections (…
View article: Screening of Leptin-LepR modulators using molecular docking and binding assay
Screening of Leptin-LepR modulators using molecular docking and binding assay Open
Leptin is a pleiotropic hormone which, upon binding to its cognate leptin receptor (LepR), induces the activation of the JAK2/ERK, /STAT3, /STAT5 and IRS/PI3 kinase signaling cascades. Hence, we used molecular docking and a chemical librar…
View article: Molecular aspects of cervical cancer: a pathogenesis update
Molecular aspects of cervical cancer: a pathogenesis update Open
Cervical cancer (CC) is a significant health problem, especially in low-income countries. Functional studies on the human papillomavirus have generated essential advances in the knowledge of CC. However, many unanswered questions remain. T…
View article: Differences in Biofilm Formation by Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Strains
Differences in Biofilm Formation by Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Strains Open
Staphylococcus aureus (S. aureus) is a common pathogen involved in community- and hospital-acquired infections. Its biofilm formation ability predisposes it to device-related infections. Methicillin-resistant S. aureus (MRSA) strains are a…
View article: Editorial: Women in mucosal immunity
Editorial: Women in mucosal immunity Open
EDITORIAL article Front. Immunol., 03 October 2023Sec. Mucosal Immunity Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1282709
View article: A trabecular micro-bypass stent combined with phacoemulsification efficiently reduces intraocular pressure in open angle glaucoma in Mexican population
A trabecular micro-bypass stent combined with phacoemulsification efficiently reduces intraocular pressure in open angle glaucoma in Mexican population Open
BACKGROUND: Glaucoma is the second most common cause of irreversible blindness worldwide. First choice treatment is the use of topical hypotensives, and surgery is the gold standard. However, there are several associated complications. Min…
View article: Paneth and Paneth-like cells undergoing necroptosis fuel intestinal epithelial cell proliferation following IFN-γ stimulation
Paneth and Paneth-like cells undergoing necroptosis fuel intestinal epithelial cell proliferation following IFN-γ stimulation Open
The quality of life in patients with inflammatory bowel diseases (IBD) is strongly impaired. Alterations of intestinal epithelial homeostasis contribute to the development and establishment of IBD. Intestinal Paneth and Paneth-like cells p…
View article: T cell activation, immune synapse formation, and organ infiltration by leukemic T cells require cortactin
T cell activation, immune synapse formation, and organ infiltration by leukemic T cells require cortactin Open
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy that is still fatal in many cases. T cell blasts are characterized by hyperactivation and strong proliferative and migratory capacities. The chemokine re…
View article: IL-36γ is secreted through an unconventional pathway using the Gasdermin D and P2X7R membrane pores
IL-36γ is secreted through an unconventional pathway using the Gasdermin D and P2X7R membrane pores Open
Mucosal innate immunity functions as the first line of defense against invading pathogens. Members of the IL-1 family are key cytokines upregulated in the inflamed mucosa. Inflammatory cytokines are regulated by limiting their function and…
View article: Isthmin 1 is Expressed by Progenitor-Like Cells in the Lung: Phenotypical Analysis of Isthmin 1+ Hematopoietic Stem-Like Cells in Homeostasis and during Infection
Isthmin 1 is Expressed by Progenitor-Like Cells in the Lung: Phenotypical Analysis of Isthmin 1+ Hematopoietic Stem-Like Cells in Homeostasis and during Infection Open
The process by which blood cells are generated has been widely studied in homeostasis and during pathogen-triggered inflammatory response. Recently, murine lungs have been shown to be a significant source of hematopoietic progenitors in a …
View article: Differentially expressed proteins in platelets derived from patients with hypertension
Differentially expressed proteins in platelets derived from patients with hypertension Open
View article: Comparative Transcriptomes of the Body Wall of Wild and Farmed Sea Cucumber Isostichopus badionotus
Comparative Transcriptomes of the Body Wall of Wild and Farmed Sea Cucumber Isostichopus badionotus Open
Overfishing of sea cucumber Isostichopus badionotus from Yucatan has led to a major population decline. They are being captured as an alternative to traditional species despite a paucity of information about their health-promoting properti…
View article: IL-36R signaling integrates innate and adaptive immune-mediated protection against enteropathogenic bacteria
IL-36R signaling integrates innate and adaptive immune-mediated protection against enteropathogenic bacteria Open
Significance Upon enteropathogenic bacterial infection, cytokines orchestrate innate and adaptive immune activation that promotes barrier protection and pathogen control. Using Citrobacter rodentium , we defined a critical role for IL-36R …
View article: Molecular Epidemiology of Acinetobacter calcoaceticus-Acinetobacter baumannii Complex Isolated From Children at the Hospital Infantil de México Federico Gómez
Molecular Epidemiology of Acinetobacter calcoaceticus-Acinetobacter baumannii Complex Isolated From Children at the Hospital Infantil de México Federico Gómez Open
The Acinetobacter calcoaceticus-baumannii (Acb) complex is regarded as a group of phenotypically indistinguishable opportunistic pathogens responsible for mainly causing hospital-acquired pneumonia and bacteremia. The …
View article: Immunonutrition in Cervical Cancer: Immune Response Modulation by Diet
Immunonutrition in Cervical Cancer: Immune Response Modulation by Diet Open
View article: Nucleoredoxin interaction with flightless‐I/actin complex is differentially altered in alcoholic liver disease
Nucleoredoxin interaction with flightless‐I/actin complex is differentially altered in alcoholic liver disease Open
Alcoholic liver disease (ALD) may be attributed to multiple hits driving several alterations. The aim of this work was to determine whether nucleoredoxin (NXN) interacts with flightless‐I (FLII)/actin complex and how this ternary complex i…
View article: A Glycosaminoglycan-Rich Fraction from Sea Cucumber Isostichopus badionotus Has Potent Anti-Inflammatory Properties In Vitro and In Vivo
A Glycosaminoglycan-Rich Fraction from Sea Cucumber Isostichopus badionotus Has Potent Anti-Inflammatory Properties In Vitro and In Vivo Open
Sea cucumber body wall contains several naturally occurring bioactive components that possess health-promoting properties. Isostichopus badionotus from Yucatan, Mexico is heavily fished, but little is known about its bioactive constituents…
View article: Immunoendocrine Peripheral Effects Induced by Atypical Antipsychotics
Immunoendocrine Peripheral Effects Induced by Atypical Antipsychotics Open
Atypical antipsychotics (AAP) or second-generation antipsychotics are the clinical option for schizophrenia treatment during acute psychoses, but they are also indicated for maintenance during lifetime, even though they are being used for …
View article: Intestinal response to dietary manganese depletion in <i>Drosophila</i>
Intestinal response to dietary manganese depletion in <i>Drosophila</i> Open
Manganese is considered essential for animal growth. Manganese ions serve as cofactors to three mitochondrial enzymes: superoxide dismutase (Sod2), arginase and glutamine synthase, and to glycosyltransferases residing in the Golgi. In Dros…
View article: Incidence and risk factors of retinopathy of prematurity in the Lic. Adolfo López Mateos Regional Hospital, ISSSTE
Incidence and risk factors of retinopathy of prematurity in the Lic. Adolfo López Mateos Regional Hospital, ISSSTE Open