Oskar Engberg
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View article: Molecules in the Serotonin-Melatonin Synthesis Pathway Have Distinct Interactions with Lipid Membranes
Molecules in the Serotonin-Melatonin Synthesis Pathway Have Distinct Interactions with Lipid Membranes Open
The neurotransmitter serotonin is involved in physiological processes such as appetite, sleep, and mood and diseases such as anxiety and depression. Traditionally, the effects of serotonin were thought to be initiated by binding to its tar…
View article: Characterization of lipid chain order and dynamics in asymmetric membranes by solid-state NMR spectroscopy
Characterization of lipid chain order and dynamics in asymmetric membranes by solid-state NMR spectroscopy Open
We studied the structure and dynamics of asymmetric POPC out /(POPE/POPG) in and POPS out /(POPE/POPG) in lipid membranes.
View article: Evaluating the impact of the membrane thickness on the function of the intramembrane protease GlpG
Evaluating the impact of the membrane thickness on the function of the intramembrane protease GlpG Open
Cellular membranes exhibit a huge diversity of lipids and membrane proteins that differ in their properties and chemical structure. Cells organize these molecules into distinct membrane compartments characterized by specific lipid profiles…
View article: The intriguing molecular dynamics of Cer[EOS] in rigid skin barrier lipid layers requires improvement of the model
The intriguing molecular dynamics of Cer[EOS] in rigid skin barrier lipid layers requires improvement of the model Open
Omega-O-acyl ceramides such as 32-linoleoyloxydotriacontanoyl sphingosine (Cer[EOS]) are essential components of the lipid skin barrier, which protects our body from excessive water loss and the penetration of unwanted substances. These ce…
View article: Rhomboid-catalyzed intramembrane proteolysis requires hydrophobic matching with the surrounding lipid bilayer
Rhomboid-catalyzed intramembrane proteolysis requires hydrophobic matching with the surrounding lipid bilayer Open
Membrane thinning by rhomboid proteins has been proposed to reduce hydrophobic mismatch, providing a unique environment for important functions ranging from intramembrane proteolysis to retrotranslocation in protein degradation. We show by…
View article: Different membrane order measurement techniques are not mutually consistent
Different membrane order measurement techniques are not mutually consistent Open
View article: Cholesterol sulfate fluidizes the sterol fraction of the stratum corneum lipid phase and increases its permeability
Cholesterol sulfate fluidizes the sterol fraction of the stratum corneum lipid phase and increases its permeability Open
View article: A method to construct the dynamic landscape of a bio-membrane with experiment and simulation
A method to construct the dynamic landscape of a bio-membrane with experiment and simulation Open
View article: A method to construct the dynamic landscape of a bio-membrane with experiment and simulation
A method to construct the dynamic landscape of a bio-membrane with experiment and simulation Open
MD simulations of palmitoyl-oleoyl-phosphatidylcholine (POPC) bilayers are provided (3 simulations). Simulation 1: 256 POPC molecules, 10.2 μs Simulation 2: 1024 POPC molecules, 9.5 μs Simulation 1: 4096 POPC molecules, 2.0 μs All simulati…
View article: A method to construct the dynamic landscape of a bio-membrane with experiment and simulation
A method to construct the dynamic landscape of a bio-membrane with experiment and simulation Open
Biomolecular function is based on a complex hierarchy of molecular motions. While biophysical methods can reveal details of specific motions, a concept for the comprehensive description of molecular dynamics over a wide range of correlatio…
View article: Probing the Unique Role of Ultralong-Chain Omega-Acylceramide Cer[EOS] in a Stratum Corneum Lipid Model Matrix using 2H NMR
Probing the Unique Role of Ultralong-Chain Omega-Acylceramide Cer[EOS] in a Stratum Corneum Lipid Model Matrix using 2H NMR Open
View article: Altered Membrane Mechanics Provides a Receptor‐Independent Pathway for Serotonin Action
Altered Membrane Mechanics Provides a Receptor‐Independent Pathway for Serotonin Action Open
Serotonin, an important signaling molecule in humans, has an unexpectedly high lipid membrane affinity. The significance of this finding has evoked considerable speculation. Here we show that membrane binding by serotonin can directly modu…
View article: Spontaneous Membrane Nanodomain Formation in the Absence or Presence of the Neurotransmitter Serotonin
Spontaneous Membrane Nanodomain Formation in the Absence or Presence of the Neurotransmitter Serotonin Open
Detailed knowledge on the formation of biomembrane domains, their structure, composition, and physical characteristics is scarce. Despite its frequently discussed importance in signaling, e.g., in obtaining localized non-homogeneous recept…
View article: Sphingomyelin Acyl Chains Influence the Formation of Sphingomyelin- and Cholesterol-Enriched Domains
Sphingomyelin Acyl Chains Influence the Formation of Sphingomyelin- and Cholesterol-Enriched Domains Open
View article: Serotonin Alters the Phase Equilibrium of a Ternary Mixture of Phospholipids and Cholesterol
Serotonin Alters the Phase Equilibrium of a Ternary Mixture of Phospholipids and Cholesterol Open
Unsaturated and saturated phospholipids tend to laterally segregate, especially in the presence of cholesterol. Small molecules such as neurotransmitters, toxins, drugs etc. possibly modulate this lateral segregation. The small aromatic ne…
View article: Sphingomyelin Acyl Chains Influence the Formation of Sphingomyelin- and Cholesterol-Enriched Domains
Sphingomyelin Acyl Chains Influence the Formation of Sphingomyelin- and Cholesterol-Enriched Domains Open
View article: Die unterschiedliche Struktur und Dynamik der Sphingosin‐ und Acylketten von Ceramid [NS] verändern unser Verständnis der Struktur der Hautbarriere
Die unterschiedliche Struktur und Dynamik der Sphingosin‐ und Acylketten von Ceramid [NS] verändern unser Verständnis der Struktur der Hautbarriere Open
Im Modell der äußeren Hautschicht wird die Lipidphase durch sehr rigide Moleküle in einer orthorhombischen Phase gebildet, die den Körper vor Umwelteinflüssen schützt. Durch Synthese von Sphingosin‐ d 28 ‐deuteriertem N ‐Lignoceroyl‐ d ‐ e…
View article: The Sphingosine and Acyl Chains of Ceramide [NS] Show Very Different Structure and Dynamics That Challenge Our Understanding of the Skin Barrier
The Sphingosine and Acyl Chains of Ceramide [NS] Show Very Different Structure and Dynamics That Challenge Our Understanding of the Skin Barrier Open
The lipid phase of the uppermost human skin layer is thought to comprise highly rigid lipids in an orthorhombic phase state to protect the body against the environment. By synthesizing sphingosine‐d 28 deuterated N‐lignoceroyl‐ d ‐erythro‐…
View article: The Effect of Serotonin on the Lateral Segregation of a Raft Membrane Mixture
The Effect of Serotonin on the Lateral Segregation of a Raft Membrane Mixture Open
View article: Impact of Acyl Chain Mismatch on the Formation and Properties of Sphingomyelin-Cholesterol Domains
Impact of Acyl Chain Mismatch on the Formation and Properties of Sphingomyelin-Cholesterol Domains Open
View article: The Affinity of Sterols for Different Phospholipid Classes and Its Impact on Lateral Segregation
The Affinity of Sterols for Different Phospholipid Classes and Its Impact on Lateral Segregation Open
View article: Interactions between Sterols and Phospholipids with Different Headgroups - Influence on Lateral Segregation
Interactions between Sterols and Phospholipids with Different Headgroups - Influence on Lateral Segregation Open
View article: Impact of Phospholipid Acyl Chain Length Mismatch on Sterol Affinity and Lateral Segregation
Impact of Phospholipid Acyl Chain Length Mismatch on Sterol Affinity and Lateral Segregation Open
View article: Bilayer Interactions among Unsaturated Phospholipids, Sterols, and Ceramide
Bilayer Interactions among Unsaturated Phospholipids, Sterols, and Ceramide Open
View article: Influence of Cholesterol on Lateral Segregation in Bilayers Containing Different Sphingomyelins and Unsaturated Phospholipids
Influence of Cholesterol on Lateral Segregation in Bilayers Containing Different Sphingomyelins and Unsaturated Phospholipids Open
View article: The Affinity of Cholesterol for Different Phospholipids Affects Lateral Segregation in Bilayers
The Affinity of Cholesterol for Different Phospholipids Affects Lateral Segregation in Bilayers Open
View article: Lipid Interactions and Organization in Complex Bilayer Membranes
Lipid Interactions and Organization in Complex Bilayer Membranes Open
View article: Comparison of Unsaturated Phospholipids Effect on Phase Separation in Cholesterol Free and Cholesterol Containing Bilayers
Comparison of Unsaturated Phospholipids Effect on Phase Separation in Cholesterol Free and Cholesterol Containing Bilayers Open
View article: Correction: Corrigendum: Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure
Correction: Corrigendum: Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure Open
View article: Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure
Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure Open