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View article: Mutant Tau (P301L) Enhances Global Protein Translation in Differentiated SH-SY5Y Cells by Upregulating mTOR Signalling
Mutant Tau (P301L) Enhances Global Protein Translation in Differentiated SH-SY5Y Cells by Upregulating mTOR Signalling Open
Altered protein synthesis plays a key role in ageing and multiple neurodegenerative diseases. In Alzheimer’s disease and other tauopathies, the intracellular accumulation of hyperphosphorylated Tau disrupts several cellular processes, incl…
View article: Foxg1 and companions: Not only transcription factors
Foxg1 and companions: Not only transcription factors Open
Moving from the most recent results on Foxg1 biology, we first summarize the available information on some special pleiotropic effectors of neurodevelopmental interest, involved in controlling both transcription and post-transcriptional st…
View article: Computational Splicing Analysis of Transcriptomic Data Reveals Sulforaphane Modulation of Alternative mRNA Splicing of DNA Repair Genes in Differentiated SH-SY5Y Neurons
Computational Splicing Analysis of Transcriptomic Data Reveals Sulforaphane Modulation of Alternative mRNA Splicing of DNA Repair Genes in Differentiated SH-SY5Y Neurons Open
Sulforaphane (SFN) is a bioactive compound belonging to the isothiocyanate family, known for its neuroprotective properties. While transcriptomic studies have highlighted SFN’s role in regulating gene expression, its impact on alternative …
View article: Cannabinerol Restores mRNA Splicing Defects Induced by β-Amyloid in an In Vitro Model of Alzheimer’s Disease: A Transcriptomic Study
Cannabinerol Restores mRNA Splicing Defects Induced by β-Amyloid in an In Vitro Model of Alzheimer’s Disease: A Transcriptomic Study Open
Alzheimer’s disease (AD) is the most common form of dementia, characterized by β-amyloid (Aβ) plaques and neurofibrillary tangles, leading to neuronal loss and cognitive impairments. Recent studies have reported the dysregulation of RNA sp…
View article: Bioactivated Glucoraphanin Improves Cell Survival, Upregulating Phospho-AKT, and Modulates Genes Involved in DNA Repair in an In Vitro Alzheimer’s Disease Model: A Network-Transcriptomic Analysis
Bioactivated Glucoraphanin Improves Cell Survival, Upregulating Phospho-AKT, and Modulates Genes Involved in DNA Repair in an In Vitro Alzheimer’s Disease Model: A Network-Transcriptomic Analysis Open
Background/Objectives: Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases, for which a definitive cure is still missing. Recently, natural compounds have been investigated for their possible neuroprotective role,…
View article: Foxg1 regulates translation of neocortical neuronal genes, including the main NMDA receptor subunit gene, Grin1
Foxg1 regulates translation of neocortical neuronal genes, including the main NMDA receptor subunit gene, Grin1 Open
These findings point to FOXG1 as a key effector, potentially crucial to multi-scale temporal tuning of neocortical pyramid activity, an issue with profound physiological and neuropathological implications.
View article: α-Cyclodextrin/Moringin Induces an Antioxidant Transcriptional Response Activating Nrf2 in Differentiated NSC-34 Motor Neurons
α-Cyclodextrin/Moringin Induces an Antioxidant Transcriptional Response Activating Nrf2 in Differentiated NSC-34 Motor Neurons Open
Oxidative stress is a common feature of neurodegenerative diseases. Different natural compounds mediate neuroprotective effects by activating the Nrf2 antioxidant response. Some isothiocyanates are Nrf2 activators, including Moringin (MOR)…
View article: Cannabinerol Prevents Endoplasmic Reticulum and Mitochondria Dysfunctions in an In Vitro Model of Alzheimer’s Disease: A Network-Based Transcriptomic Analysis
Cannabinerol Prevents Endoplasmic Reticulum and Mitochondria Dysfunctions in an In Vitro Model of Alzheimer’s Disease: A Network-Based Transcriptomic Analysis Open
Neurodegenerative disorders are affecting millions of people worldwide, impacting the healthcare system of our society. Among them, Alzheimer’s disease (AD) is the most common form of dementia, characterized by severe cognitive impairments…
View article: <i>Foxg1</i> bimodally tunes <i>L1</i>-mRNA and -DNA dynamics in the developing murine neocortex
<i>Foxg1</i> bimodally tunes <i>L1</i>-mRNA and -DNA dynamics in the developing murine neocortex Open
Foxg1 masters telencephalic development via a pleiotropic control over its progression. Expressed within the central nervous system (CNS), L1 retrotransposons are implicated in progression of its histogenesis and tuning of its genomic plas…
View article: Cannabinerol (CBNR) Influences Synaptic Genes Associated with Cytoskeleton and Ion Channels in NSC-34 Cell Line: A Transcriptomic Study
Cannabinerol (CBNR) Influences Synaptic Genes Associated with Cytoskeleton and Ion Channels in NSC-34 Cell Line: A Transcriptomic Study Open
Cannabinoids are receiving great attention as a novel approach in the treatment of cognitive and motor disabilities, which characterize neurological disorders. To date, over 100 phytocannabinoids have been extracted from Cannabis sativa, a…
View article: Foxg1 regulates translation of neocortical neuronal genes, including the main NMDA receptor subunit gene,<i>Grin1</i>
Foxg1 regulates translation of neocortical neuronal genes, including the main NMDA receptor subunit gene,<i>Grin1</i> Open
Mainly known as a transcription factor patterning the rostral brain and governing its histogenesis, Foxg1 has been also detected outside the nucleus, however biological meaning of that has been only partially clarified. Here, moving from F…
View article: The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress
The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress Open
Chromatin organization plays a crucial role in tissue homeostasis. Heterochromatin relaxation and consequent unscheduled mobilization of transposable elements (TEs) are emerging as key contributors of aging and aging-related pathologies, i…
View article: Foxg1 Upregulation Enhances Neocortical Activity
Foxg1 Upregulation Enhances Neocortical Activity Open
Foxg1 is an ancient transcription factor gene orchestrating a number of neurodevelopmental processes taking place in the rostral brain. In this study, we investigated its impact on neocortical activity. We found that mice overexpressing Fo…
View article: RNASeq profiling of Foxg1-GOF neocortical neurons.v2
RNASeq profiling of Foxg1-GOF neocortical neurons.v2 Open
The dataset uploaded in this entry includes data referred to by the manuscript "Foxg1 upregulation enhances neocortical projection neuron activity", by Wendalina Tigani, Moira Pinzan Rossi et al. (submitted).
View article: RNASeq profiling of Foxg1-GOF neocortical neurons.v2
RNASeq profiling of Foxg1-GOF neocortical neurons.v2 Open
The dataset uploaded in this entry includes data referred to by the manuscript "Foxg1 upregulation enhances neocortical projection neuron activity", by Wendalina Tigani, Moira Pinzan Rossi et al. (submitted).
View article: RNASeq profiling of Foxg1-GOF neocortical neurons
RNASeq profiling of Foxg1-GOF neocortical neurons Open
The dataset uploaded in this entry includes data referred to by the manuscript "Foxg1 upregulation enhances neocortical projection neuron activity", by Wendalina Tigani, Moira Pinzan Rossi et al. (submitted).