Otávio Cabral-Marques
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View article: Artificial intelligence and systems biology analysis in stem cell research and therapeutics development
Artificial intelligence and systems biology analysis in stem cell research and therapeutics development Open
Background: Stem cell research has rapidly advanced during the past decades, but the translation into approved clinical products is still lagging behind. Multiple barriers to effective clinical translation exist. We hypothesize that an ine…
View article: Whole-Genome Sequencing Analysis of Drug-Resistant Salmonella Typhi in Children
Whole-Genome Sequencing Analysis of Drug-Resistant Salmonella Typhi in Children Open
Typhoid fever, caused by Salmonella enterica subsp. enterica serovar Typhi (S. typhi), remains a major public health concern, particularly in low-resource settings with poor sanitation. The emergence of multidrug-resistant (MDR) and extens…
View article: Genomic insights into pyrazinamide and fluoroquinolone resistance in multidrug-resistant tuberculosis in Khyber Pakhtunkhwa, Pakistan
Genomic insights into pyrazinamide and fluoroquinolone resistance in multidrug-resistant tuberculosis in Khyber Pakhtunkhwa, Pakistan Open
View article: Modulation of neuroimmune cytokine networks by antidepressants: implications in mood regulation
Modulation of neuroimmune cytokine networks by antidepressants: implications in mood regulation Open
View article: HTLV-1-Induced Neuroimmunome Correlates with Disease Progression and Severity
HTLV-1-Induced Neuroimmunome Correlates with Disease Progression and Severity Open
View article: Uncaria tomentosa as a Promising Natural Source of Molecules with Multiple Activities: Review of Its Ethnomedicinal Uses, Phytochemistry and Pharmacology
Uncaria tomentosa as a Promising Natural Source of Molecules with Multiple Activities: Review of Its Ethnomedicinal Uses, Phytochemistry and Pharmacology Open
Uncaria tomentosa (Ut) is a Rubiaceae widely used in Peru’s traditional medicine. It is mainly known by the vernacular name of Cat’s claw due to its morphological aspects and is found in tropical low mountain forests of Central and South A…
View article: Advancing research on regulatory autoantibodies targeting GPCRs: Insights from the 5th international symposium
Advancing research on regulatory autoantibodies targeting GPCRs: Insights from the 5th international symposium Open
The 5th International Symposium on Regulatory Autoantibodies Targeting GPCR (RAB-GPCRs) advanced the understanding of the significant role played by autoantibodies targeting G-protein-coupled receptors (GPCRs) in various human diseases. On…
View article: COVID-19 vaccination atlas using an integrative systems vaccinology approach
COVID-19 vaccination atlas using an integrative systems vaccinology approach Open
The COVID-19 vaccinations have played a significant role in controlling the pandemic. To elucidate their impact on the immune system, a COVID-19 vaccination atlas was developed using an integrative systems vaccinology approach. The atlas i…
View article: Long COVID-19 autoantibodies and their potential effect on fertility
Long COVID-19 autoantibodies and their potential effect on fertility Open
Impaired spermatogenesis has been reported in coronavirus disease 2019 (COVID-19) patients. However, the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on male fertility remains unclear. The purpose of this multicen…
View article: A VLPs based vaccine protects against Zika virus infection and prevents cerebral and testicular damage
A VLPs based vaccine protects against Zika virus infection and prevents cerebral and testicular damage Open
Still, Zika virus (ZIKV) infection poses a substantial public health risk, especially for pregnant women and their fetuses, as it can result in congenital abnormalities and fetal mortality during pregnancy. Despite significant advances in …
View article: Medulloblastoma’s master regulators and their association with patients’ risk
Medulloblastoma’s master regulators and their association with patients’ risk Open
View article: The neuroimmunome of hepatitis patients associates with disease severity
The neuroimmunome of hepatitis patients associates with disease severity Open
View article: Gene regulatory networks analysis for the discovery of prognostic genes in gliomas
Gene regulatory networks analysis for the discovery of prognostic genes in gliomas Open
Gliomas are the most common and aggressive primary tumors of the central nervous system. Dysregulated transcription factors (TFs) and genes have been implicated in glioma progression, yet these tumors' overall structure of gene regulatory …
View article: Integrative immunology identified interferome signatures in uveitis and systemic disease-associated uveitis
Integrative immunology identified interferome signatures in uveitis and systemic disease-associated uveitis Open
Introduction Uveitis accounts for up to 25% of global legal blindness and involves intraocular inflammation, classifed as infectious or non-infectious. Its complex pathophysiology includes dysregulated cytokines, particularly interferons (…
View article: Stimulation of endothelin-1 production by autoantibodies present in patients with scleroderma renal crisis
Stimulation of endothelin-1 production by autoantibodies present in patients with scleroderma renal crisis Open
Here, we investigate how autoantibodies against G protein-coupled receptors (GPCRs) on endothelial cells, which are present in patients with scleroderma renal crisis (SRC) impact on endothelin-1 (ET-1) production in human microvascular end…
View article: Dysregulated autoantibodies targeting AGTR1 are associated with the accumulation of COVID-19 symptoms
Dysregulated autoantibodies targeting AGTR1 are associated with the accumulation of COVID-19 symptoms Open
Coronavirus disease 2019 (COVID-19) presents a wide spectrum of symptoms, the causes of which remain poorly understood. This study explored the associations between autoantibodies (AABs), particularly those targeting G protein-coupled rece…
View article: The Autoantibodyome Neuroimmune Signature of Neurodegeneration
The Autoantibodyome Neuroimmune Signature of Neurodegeneration Open
View article: VaxGO: an interactive web tool for systems vaccinology data analysis
VaxGO: an interactive web tool for systems vaccinology data analysis Open
Motivation RNA sequencing is crucial for investigating transcriptional patterns in immunology and vaccine research. However, the analysis of RNA sequencing data often requires programming skills, which can limit accessibility for researche…
View article: Dysregulation of synaptic-related genes of neuroimmune networks within peripheral blood mononuclear cells in major depressive disorder
Dysregulation of synaptic-related genes of neuroimmune networks within peripheral blood mononuclear cells in major depressive disorder Open
Major depressive disorder (MDD) involves complex neuroimmune interactions linked to gene modulation. Our study investigates synaptic-related gene dysregulation in peripheral blood mononuclear cells (PBMCs) from MDD patients, showing how th…
View article: A self-adjuvanted VLPs-based Covid-19 vaccine proven versatile, safe, and highly protective
A self-adjuvanted VLPs-based Covid-19 vaccine proven versatile, safe, and highly protective Open
Vaccination has played a critical role in mitigating COVID-19. Despite the availability of licensed vaccines, there remains a pressing need for improved vaccine platforms that provide high protection, safety, and versatility, while also re…
View article: ANÁLISE DE ONTOLOGIA GENÉTICA PARA INSIGHTS NOS MARCADORES CELULARES DAS LEUCEMIAS AGUDAS
ANÁLISE DE ONTOLOGIA GENÉTICA PARA INSIGHTS NOS MARCADORES CELULARES DAS LEUCEMIAS AGUDAS Open
Objetivo: Este estudo visa explorar a interconexão entre genes associados aos marcadores de citometria de fluxo nas leucemias agudas (LAs), e os processos biológicos que eles regulam, utilizando a análise de ontologia genética. Buscamos id…
View article: Integrative systems neuroimmunology reveals leukocyte-expressing PAX6 as a critical predictor of major depressive disorder
Integrative systems neuroimmunology reveals leukocyte-expressing PAX6 as a critical predictor of major depressive disorder Open
Major depressive disorder (MDD) is a complex psychiatric condition with a significant global impact. This study applied a genomic-driven integrative systems neuroimmunology approach to analyze transcriptomic data from 3,114 individuals (1,…
View article: Exploring the Antimicrobial Resistance Profile of Salmonella typhi and Its Clinical Burden
Exploring the Antimicrobial Resistance Profile of Salmonella typhi and Its Clinical Burden Open
Background: Typhoid fever caused by Salmonella enterica serovar Typhi (S. typhi) continues to pose a significant risk to public health in developing countries, including Pakistan. This study investigated the epidemiological factors linked …
View article: COVID-19 vaccination atlas: an integrative systems vaccinology approach
COVID-19 vaccination atlas: an integrative systems vaccinology approach Open
The COVID-19 vaccinations have played a significant role in controlling the pandemic. To elucidate their impact on the immune system, a COVID-19 vaccination atlas was developed through an integrative systems vaccinology approach. The atlas…
View article: Single-cell resolution characterization of myeloid-derived cell states with implication in cancer outcome
Single-cell resolution characterization of myeloid-derived cell states with implication in cancer outcome Open
Tumor-associated myeloid-derived cells (MDCs) significantly impact cancer prognosis and treatment responses due to their remarkable plasticity and tumorigenic behaviors. Here, we integrate single-cell RNA-sequencing data from different can…
View article: Immunophenotype signatures in acute leukemias unveiled by integrative systems immunology
Immunophenotype signatures in acute leukemias unveiled by integrative systems immunology Open
Acute leukemias (ALs) are complex hematological disorders, and accurate diagnosis is crucial for guiding treatment decisions and predicting patient outcomes. While changes in cell marker levels are well documented, the impact of these chan…
View article: COVID-19 vaccination atlas: an integrative systems vaccinology approach
COVID-19 vaccination atlas: an integrative systems vaccinology approach Open
The COVID-19 vaccinations have played a significant role in controlling the pandemic. To elucidate their impact on the immune system, a COVID-19 vaccination atlas was developed through an integrative systems vaccinology approach. The atlas…
View article: Systems Immunology Approaches to Understanding Immune Responses in Acute Infection of Yellow Fever Patients
Systems Immunology Approaches to Understanding Immune Responses in Acute Infection of Yellow Fever Patients Open
Summary In the 2018 yellow fever (YF) outbreak in Brazil, we generated new transcriptomic data and combined it with clinical and immunological data to decode the pathogenesis of YF. Our analysis of 79 patients highlighted distinct gene exp…
View article: Integrative Systems Immunology Analysis Reveals Elevated Anti-AGTR1 Levels with Accumulating COVID-19 Symptoms
Integrative Systems Immunology Analysis Reveals Elevated Anti-AGTR1 Levels with Accumulating COVID-19 Symptoms Open
The coronavirus disease 2019 (COVID-19) displays a broad spectrum of symptoms, with the underlying reasons for this variability still not fully elucidated. Our study investigates the potential association between specific autoantibodies (A…
View article: Blocking the CTLA-4 and PD-1 pathways during pulmonary paracoccidioidomycosis improves immunity, reduces disease severity, and increases the survival of infected mice
Blocking the CTLA-4 and PD-1 pathways during pulmonary paracoccidioidomycosis improves immunity, reduces disease severity, and increases the survival of infected mice Open
Immune checkpoint pathways, i.e., coinhibitory pathways expressed as feedback following immune activation, are crucial for controlling an excessive immune response. Cytotoxic T lymphocyte antigen-4 (CTLA-4) and programmed cell death protei…