Otto Luiz Dutra Cerqueira
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View article: Prognostic value of Maspin protein level in patients with triple negative breast cancer
Prognostic value of Maspin protein level in patients with triple negative breast cancer Open
The search for prognostic markers in breast cancer has bumped into a typical feature of these tumors, intra and intertumoral heterogeneity. Changes in the expression profile, localization of these proteins or shedding to the surrounding st…
View article: Prognostic value of integrin αV expression and localization pattern in invasive breast carcinomas
Prognostic value of integrin αV expression and localization pattern in invasive breast carcinomas Open
View article: Perspectives for Combining Viral Oncolysis With Additional Immunotherapies for the Treatment of Melanoma
Perspectives for Combining Viral Oncolysis With Additional Immunotherapies for the Treatment of Melanoma Open
Melanoma is the deadliest type of skin cancer with steadily increasing incidence worldwide during the last few decades. In addition to its tumor associated antigens (TAAs), melanoma has a high mutation rate compared to other tumors, which …
View article: Nonreplicating Adenoviral Vectors: Improving Tropism and Delivery of Cancer Gene Therapy
Nonreplicating Adenoviral Vectors: Improving Tropism and Delivery of Cancer Gene Therapy Open
Recent preclinical and clinical studies have used viral vectors in gene therapy research, especially nonreplicating adenovirus encoding strategic therapeutic genes for cancer treatment. Adenoviruses were the first DNA viruses to go into th…
View article: Combined p14ARF and Interferon-β Gene Transfer to the Human Melanoma Cell Line SK-MEL-147 Promotes Oncolysis and Immune Activation
Combined p14ARF and Interferon-β Gene Transfer to the Human Melanoma Cell Line SK-MEL-147 Promotes Oncolysis and Immune Activation Open
Immune evasion is an important cancer hallmark and the understanding of its mechanisms has generated successful therapeutic approaches. Induction of immunogenic cell death (ICD) is expected to attract immune cell populations that promote i…
View article: Response of human melanoma cell lines to interferon-beta gene transfer mediated by a modified adenoviral vector
Response of human melanoma cell lines to interferon-beta gene transfer mediated by a modified adenoviral vector Open
View article: Gene-based Interventions for Cancer Immunotherapy
Gene-based Interventions for Cancer Immunotherapy Open
Immunotherapy of cancer has deservedly gained much attention in the past few years and is likely to continue to advance and become a fundamental cancer treatment. While vaccines, chimeric antigen receptor (CAR) T cells and checkpoint block…
View article: High CD90 (THY-1) expression positively correlates with cell transformation and worse prognosis in basal-like breast cancer tumors
High CD90 (THY-1) expression positively correlates with cell transformation and worse prognosis in basal-like breast cancer tumors Open
Breast cancer is the most prevalent cancer among women, with the basal-like triple negative (TNBC) being the most agressive one, displaying the poorest prognosis within the ductal carcinoma subtype. Due to the lack of adequate molecular ta…
View article: Perspectives for cancer immunotherapy mediated by p19Arf plus interferon-beta gene transfer
Perspectives for cancer immunotherapy mediated by p19Arf plus interferon-beta gene transfer Open
While cancer immunotherapy has gained much deserved attention in recent years, many areas regarding the optimization of such modalities remain unexplored, including the development of novel approaches and the strategic combination of thera…
View article: CIP4 promotes metastasis in triple-negative breast cancer and is associated with poor patient prognosis
CIP4 promotes metastasis in triple-negative breast cancer and is associated with poor patient prognosis Open
Signaling via epidermal growth factor receptor (EGFR) and Src kinase pathways promote triple-negative breast cancer (TNBC) cell invasion and tumor metastasis. Here, we address the role of Cdc42-interacting protein-4 (CIP4) in TNBC metastas…