Oumaima Ahmed
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View article: O-GlcNAcylation of FOXK1 co-opts BAP1 to orchestrate the E2F pathway and promotes oncogenesis
O-GlcNAcylation of FOXK1 co-opts BAP1 to orchestrate the E2F pathway and promotes oncogenesis Open
The E2F transcription factors constitute a core transcriptional network that governs cell division and oncogenesis in multi-cellular organisms, although their molecular mechanisms remain incompletely understood. Here, we show that elevated…
View article: O-GlcNAcylation of FOXK1 orchestrates the E2F pathway and promotes oncogenesis
O-GlcNAcylation of FOXK1 orchestrates the E2F pathway and promotes oncogenesis Open
Gene transcription is a highly regulated process, and deregulation of transcription factors activity underlies numerous pathologies including cancer. Albeit near four decades of studies have established that the E2F pathway is a core trans…
View article: Persistent Acetylation of Histone H3 Lysine 56 Compromises the Activity of DNA Replication Origins
Persistent Acetylation of Histone H3 Lysine 56 Compromises the Activity of DNA Replication Origins Open
In Saccharomyces cerevisiae, newly synthesized histones H3 are acetylated on lysine 56 (H3 K56ac) by the Rtt109 acetyltransferase prior to their deposition on nascent DNA behind replication forks. Two deacetylases of the sirtuin fam…
View article: Immunoprecipitation and Western blot-based detection of protein O-GlcNAcylation in cells
Immunoprecipitation and Western blot-based detection of protein O-GlcNAcylation in cells Open
View article: Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis
Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis Open
Eukaryotic cells have evolved highly orchestrated protein catabolic machineries responsible for the timely and selective disposal of proteins and organelles, thereby ensuring amino acid recycling. However, how protein degradation is coordi…
View article: Surviving the host–pathogen interaction: Legionella uses its SidE arsenal to mediate phosphoribosyl-linked ubiquitination of Golgi proteins inducing organelle fragmentation
Surviving the host–pathogen interaction: Legionella uses its SidE arsenal to mediate phosphoribosyl-linked ubiquitination of Golgi proteins inducing organelle fragmentation Open
View article: Roles and mechanisms of BAP1 deubiquitinase in tumor suppression
Roles and mechanisms of BAP1 deubiquitinase in tumor suppression Open
View article: Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1
Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1 Open
View article: Régulation du complexe suppresseur de tumeurs BAP1/ASXL2 par ubiquitination
Régulation du complexe suppresseur de tumeurs BAP1/ASXL2 par ubiquitination Open
Introduction: La monoubiquitination de l'histone H2A sur la lysine 119 (H2AK119ub) est une modification épigénomique, catalysée par le complexe Polycomb PRC1 par le biais de l’ubiquitine ligase Ring1B /BMI1. Cette modification joue un rôle…