Oumar Faye
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View article: Molecular Characterization of Rift Valley Fever Virus From the 2025 Outbreak in Northern Senegal Reveals Lineage H Persistence and Key Polymerase Mutations
Molecular Characterization of Rift Valley Fever Virus From the 2025 Outbreak in Northern Senegal Reveals Lineage H Persistence and Key Polymerase Mutations Open
Rift Valley fever virus (RVFV) is a mosquito‐borne phlebovirus that causes severe febrile and hemorrhagic illness in humans. In September 2025, an outbreak in northern Senegal led to 119 confirmed infections and 15 deaths as of October 7, …
View article: Polygenic viral factors enable efficient mosquito-borne transmission of African Zika virus
Polygenic viral factors enable efficient mosquito-borne transmission of African Zika virus Open
Zika virus (ZIKV) is a mosquito-borne orthoflavivirus primarily transmitted among humans by Aedes aegypti. Over the past two decades, it has caused significant outbreaks associated with birth defects and neurological disorders. ZIKV consis…
View article: Evaluating Orthoflavivirus Vaccines with PRNT: Lessons from Yellow Fever Clinical Studies
Evaluating Orthoflavivirus Vaccines with PRNT: Lessons from Yellow Fever Clinical Studies Open
Flaviviruses represent a major global health concern, with yellow fever virus (YFV) and dengue virus (DENV) among the most studied members of the Orthoflavivirus genus. Transmitted by Aedes mosquitoes, these viruses are responsible for sev…
View article: Lineage H Rift Valley Fever Virus Drives Deadly 2025 Outbreak in Northern Senegal
Lineage H Rift Valley Fever Virus Drives Deadly 2025 Outbreak in Northern Senegal Open
In late September 2025, a deadly Rift Valley fever outbreak in northern Senegal caused 44 cases and 8 deaths. Sequencing confirmed lineage H persistence with three novel polymerase mutations suggesting adaptation. Ongoing concurrent One He…
View article: Hepatitis E Prevalence among Acute Febrile Jaundice Patients in Senegal, 2008–2020
Hepatitis E Prevalence among Acute Febrile Jaundice Patients in Senegal, 2008–2020 Open
Hepatitis E, caused by hepatitis E virus (HEV), is a highly endemic disease with a major public health impact. In Senegal, the first HEV outbreak was identified in 2014 in Kedougou, and a recent study focusing on pregnant women showed a se…
View article: First Report of Dengue Virus in Sierra Leone: Implications for Arbovirus Surveillance and Control
First Report of Dengue Virus in Sierra Leone: Implications for Arbovirus Surveillance and Control Open
Dengue is the leading mosquito-borne viral cause of human illness and death. More than four billion people globally live at risk of Dengue Virus (DENV) infection and most infections are asymptomatic or present with a non-specific febrile i…
View article: Field Evaluation of Mobile Molecular Differential Tests in DRC and Nigeria
Field Evaluation of Mobile Molecular Differential Tests in DRC and Nigeria Open
Background Accurate and timely differential diagnoses are a challenge for health care, particularly in infrastructure-poor settings. Methods To investigate fevers of unknown origin in Africa, a mobile suitcase laboratory was deployed to DR…
View article: NR5A1 gene variants in infertile Senegalese men: Discovery of a novel missense variant and genotype-phenotype correlation
NR5A1 gene variants in infertile Senegalese men: Discovery of a novel missense variant and genotype-phenotype correlation Open
The NR5A1 gene, encoding Steroidogenic Factor 1 (SF-1), plays a critical role in sex differentiation and spermatogenesis. However, data on NR5A1 variants in sub-Saharan African populations remain limited. This exploratory pilot study aimed…
View article: A DNA vaccine candidate provides protection against Rift Valley Fever virus in sheep under natural field conditions
A DNA vaccine candidate provides protection against Rift Valley Fever virus in sheep under natural field conditions Open
Rift Valley Fever virus (RVFV) is a mosquito-borne zoonotic pathogen, that causes significant morbidity and mortality in livestock, including high abortion rates in pregnant animals and elevated case fatality in neonates, representing a ma…
View article: Global In-Silico Performance Assessment of the CDC Zika Trioplex Detection System
Global In-Silico Performance Assessment of the CDC Zika Trioplex Detection System Open
Arboviruses, transmitted by arthropod vectors such as mosquitoes and ticks, represent a significant public health challenge due to their association with high mortality rates and the absence of vaccines or effective treatments. Dengue, Zik…
View article: Crimean–Congo Hemorrhagic Fever Outbreak in Podor, Northern Senegal in 2022: Two Independent Emergences and Unprecedented Mortality
Crimean–Congo Hemorrhagic Fever Outbreak in Podor, Northern Senegal in 2022: Two Independent Emergences and Unprecedented Mortality Open
Crimean–Congo hemorrhagic fever (CCHF) is a lethal zoonotic disease transmitted through tick bites and contact with infected animals or humans. As CCHF continues to expand worldwide, we report on the first severe outbreak in Senegal (Podor…
View article: Re-emergence of Crimean Congo hemorrhagic fever virus in Kedougou, south-eastern Senegal in 2023: Epidemiological and zoological investigations of the first symptomatic human case
Re-emergence of Crimean Congo hemorrhagic fever virus in Kedougou, south-eastern Senegal in 2023: Epidemiological and zoological investigations of the first symptomatic human case Open
Crimean-Congo hemorrhagic fever (CCHF) is a zoonosis transmitted mainly by ticks. In Senegal, the CCHF virus has been circulating since at least 2003. However, the first symptomatic human case was detected and confirmed only in 2023 in the…
View article: Genomic Insights into Neglected Orthobunyaviruses: Molecular Characterization and Phylogenetic Analysis
Genomic Insights into Neglected Orthobunyaviruses: Molecular Characterization and Phylogenetic Analysis Open
Orthobunyaviruses are a diverse group of segmented RNA viruses with significant but underexplored public and veterinary health implications. This study provides a genomic, phylogenetic, and ecological analysis of neglected Orthobunyaviruse…
View article: Seroprevalence of dengue in the Democratic Republic of Congo, Ghana and Senegal: results of the SERODEN study
Seroprevalence of dengue in the Democratic Republic of Congo, Ghana and Senegal: results of the SERODEN study Open
Introduction: There are limited data on dengue transmission across most of African countries, including Senegal, Ghana, and the Democratic Republic of the Congo (DRC). We aimed to assess the age-stratified dengue seroprevalence and estimat…
View article: Innovative methodological approach to assess dengue transmission: findings from the SERODEN study in Africa
Innovative methodological approach to assess dengue transmission: findings from the SERODEN study in Africa Open
Introduction: A limited number of dengue seroprevalence surveys have been conducted across Africa, with only 21 studies reported to date. Implementing new surveys to assess dengue transmission can be costly, time-consuming and resource int…
View article: Polygenic viral factors enable efficient mosquito-borne transmission of African Zika virus
Polygenic viral factors enable efficient mosquito-borne transmission of African Zika virus Open
Zika virus (ZIKV) is a mosquito-borne flavivirus primarily transmitted among humans by Aedes aegypti . Over the past two decades, it has caused significant outbreaks associated with birth defects and neurological disorders. Phylogeneticall…
View article: Case report: Kinetics of viral load, immunoglobulins, and cytokines in a fatal case of Crimean-Congo hemorrhagic fever virus
Case report: Kinetics of viral load, immunoglobulins, and cytokines in a fatal case of Crimean-Congo hemorrhagic fever virus Open
A fatal case of Crimean-Congo hemorrhagic fever virus (CCHFV) was detected in Dakar, Senegal, West Africa, in April 2023. To elucidate the mechanisms involved in this outcome, the kinetics of viral load, immunoglobulins, and cytokines were…
View article: Detection of an Imported Case of Severe Crimean-Congo Hemorrhagic Fever in a Patient with Comorbidities, Dakar, Senegal 2023
Detection of an Imported Case of Severe Crimean-Congo Hemorrhagic Fever in a Patient with Comorbidities, Dakar, Senegal 2023 Open
In July 2023, a diabetic from Mauritania was diagnosed as a severe case of Crimean-Congo hemorrhagic fever (CCHF) at Dakar hospital, Senegal. The phylogenetic analysis revealed the new strain as a CCHF virus reassortant between Genotype Ⅰ …
View article: Evaluation of a Luminex‐Based Multiplex Immunoassay of Hemorrhagic Fever Viruses in Senegal
Evaluation of a Luminex‐Based Multiplex Immunoassay of Hemorrhagic Fever Viruses in Senegal Open
Given the growing threat posed by viral hemorrhagic fevers, the development of surveillance tools is crucial to provide accurate and rapid solutions. Public health response involves risk assessment as well as effective and sustainable surv…
View article: Klinefelter Mosaicism 46, XX/47, XXY with Ovotestis- DSD
Klinefelter Mosaicism 46, XX/47, XXY with Ovotestis- DSD Open
Klinefelter syndrome is a relatively common chromosomal condition affecting approximately 1 in 500-1,000 males. 46, XX /47 XXY Klinefelter Syndrome mosaicism is rare enough, resulting in a few cases described in literature. Variable phenot…
View article: Genomic characterization of a reemerging Chikungunya outbreak in Kedougou, Southeastern Senegal, 2023
Genomic characterization of a reemerging Chikungunya outbreak in Kedougou, Southeastern Senegal, 2023 Open
Chikungunya virus has caused millions of cases worldwide over the past 20 years, with recent outbreaks in Kedougou region in the southeastern Senegal, West Africa. Genomic characterization highlights that an ongoing epidemic in Kedougou in…
View article: Re-Emergence of Rift Valley Fever Virus Lineage H in Senegal in 2022: In Vitro Characterization and Impact on Its Global Emergence in West Africa
Re-Emergence of Rift Valley Fever Virus Lineage H in Senegal in 2022: In Vitro Characterization and Impact on Its Global Emergence in West Africa Open
Rift Valley fever (RVF) is a re-emerging vector-borne zoonosis with a high public health and veterinary impact. In West Africa, many lineages were previously detected, but since 2020, lineage H from South Africa has been the main cause of …