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View article: Enhancing health through phenolic compounds: A comprehensive review of spices and herbs consumed in Cameroon based on global research
Enhancing health through phenolic compounds: A comprehensive review of spices and herbs consumed in Cameroon based on global research Open
For centuries, various cultures worldwide have utilized spices and herbs (S&H) not only for their culinary attributes but also for their medicinal properties. These natural substances are abundant in phenolic compounds (PCs), a category of…
View article: Effects of Storage Temperature and Spices Incorporation on the Stability and Antibacterial Properties of <i>Fontitrygon margarita</i> (Günther, 1870) Liver Oil
Effects of Storage Temperature and Spices Incorporation on the Stability and Antibacterial Properties of <i>Fontitrygon margarita</i> (Günther, 1870) Liver Oil Open
Fontitrygon margarita liver oil, rich in unsaturated fatty acids, is susceptible to oxidation during storage, which can diminish its antibacterial qualities. This study examines the effects of storage temperature and the addition of spices…
View article: Physicochemical Characteristics and Nutritional and Biological Properties of Fish Oils in Cameroon: An Overview
Physicochemical Characteristics and Nutritional and Biological Properties of Fish Oils in Cameroon: An Overview Open
Due to their significant health benefits, fish oils have garnered increasing interest in recent decades. However, Cameroon’s fish oil market remains insignificant, and the few available products are imported, despite the country’s abundant…
View article: An overview of natural products that modulate the expression of non-coding RNAs involved in oxidative stress and inflammation-associated disorders
An overview of natural products that modulate the expression of non-coding RNAs involved in oxidative stress and inflammation-associated disorders Open
Oxidative stress is a state in which oxidants are produced in excess in the body’s tissues and cells, resulting in a biological imbalance amid the generation of reactive oxygen and nitrogen species (RONS) from redox reactions. In case of i…
View article: Modified fibrin hydrogel for sustained delivery of RNAi lipopolyplexes in skeletal muscle
Modified fibrin hydrogel for sustained delivery of RNAi lipopolyplexes in skeletal muscle Open
RNA interference is a promising therapeutical approach presently hindered by delivery concerns such as rapid RNA degradation and targeting of individual tissues. Injectable hydrogels are one potentially simple and direct route towards over…
View article: TNF and HNRNPL Related Immunoregulatory Long non-coding RNA (THRIL) and long intergenic noncoding RNA-p21 (lincRNA-p21) as potential useful biomarkers for the diagnosis of tuberculosis
TNF and HNRNPL Related Immunoregulatory Long non-coding RNA (THRIL) and long intergenic noncoding RNA-p21 (lincRNA-p21) as potential useful biomarkers for the diagnosis of tuberculosis Open
Early diagnosis is crucial in controlling tuberculosis globally and in developing countries with the emergence of drug-resistant Mycobacterium tuberculosis strains. Long non-coding RNAs (lncRNAs) are promising tuberculosis diagnostic bioma…
View article: p50-associated Cyclooxygenase-2 Extragenic RNA (PACER) and Long Non-coding RNA 13 (LNC13) as potential biomarkers for monitoring tuberculosis treatment
p50-associated Cyclooxygenase-2 Extragenic RNA (PACER) and Long Non-coding RNA 13 (LNC13) as potential biomarkers for monitoring tuberculosis treatment Open
Gaps in early and accurate diagnosis, effective drug control, and treatment monitoring are hindering the global eradication effort of tuberculosis. This infectious disease has become the deadliest worldwide before the outbreak of Covid-19.…
View article: Lyl1-deficiency promotes inflammatory responses and increases mycobacterial burden in response to Mycobacterium tuberculosis infection in mice
Lyl1-deficiency promotes inflammatory responses and increases mycobacterial burden in response to Mycobacterium tuberculosis infection in mice Open
Lymphoblastic leukemia 1 (Lyl1) is a well-studied transcription factor known to exhibit oncogenic potential in various forms of leukemia with pivotal roles in hematopoietic stem cell biology. While its role in early hematopoiesis is well e…
View article: Chemical Characterization and Antibacterial Properties of Fontitrygon margarita (Günther, 1870) Liver Oil
Chemical Characterization and Antibacterial Properties of Fontitrygon margarita (Günther, 1870) Liver Oil Open
Objective. The aim of this study was to determine the chemical characteristics and antibacterial activity of Fontitrygon margarita liver oil against the bacteria responsible for food poisoning. Methods. Oils were extracted from F. margarit…
View article: Host-Directed Targeting of LincRNA-MIR99AHG Suppresses Intracellular Growth of <i>Mycobacterium tuberculosis</i>
Host-Directed Targeting of LincRNA-MIR99AHG Suppresses Intracellular Growth of <i>Mycobacterium tuberculosis</i> Open
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) kills 1.6 million people worldwide every year, and there is an urgent need for targeting host-pathogen interactions as a strategy to reduce mycobacterial resistance to cur…
View article: Effects of symbiotic population impairment on microbiome composition and longevity of <i>Bactrocera dorsalis</i>
Effects of symbiotic population impairment on microbiome composition and longevity of <i>Bactrocera dorsalis</i> Open
In order to understand the role of symbionts for their insect hosts, it is customary to treat them with antibiotics or to sterilize eggs (treatments), resulting in aposymbiotic and axenic insects, respectively. Such axenic insects can then…
View article: Decision letter: Mycobacterium tuberculosis canonical virulence factors interfere with a late component of the TLR2 response
Decision letter: Mycobacterium tuberculosis canonical virulence factors interfere with a late component of the TLR2 response Open
View article: Non-Coding RNAs in the Etiology and Control of Major and Neglected Human Tropical Diseases
Non-Coding RNAs in the Etiology and Control of Major and Neglected Human Tropical Diseases Open
Non-coding RNAs (ncRNAs) including microRNAs (miRs) and long non-coding RNAs (lncRNAs) have emerged as key regulators of gene expression in immune cells development and function. Their expression is altered in different physiological and d…
View article: Divergence of Cultivable Bacteria Associated with Larvae and Adult Bactrocera dorsalis (Diptera: Tephritidae) Laboratory-Reared Strains
Divergence of Cultivable Bacteria Associated with Larvae and Adult Bactrocera dorsalis (Diptera: Tephritidae) Laboratory-Reared Strains Open
Insects entertain intricate and mutualistic relationship with an array of microorganisms, which significantly influence their fitness, ecology and evolution. In recent decades, there has been increasing interest toward studying the effects…
View article: Triptolide Modulates the Expression of Inflammation-Associated lncRNA-PACER and lincRNA-p21 in Mycobacterium tuberculosis–Infected Monocyte-Derived Macrophages
Triptolide Modulates the Expression of Inflammation-Associated lncRNA-PACER and lincRNA-p21 in Mycobacterium tuberculosis–Infected Monocyte-Derived Macrophages Open
Triptolide is a diterpene triepoxide, which performs its biological activities via mechanisms including induction of apoptosis, targeting of pro-inflammatory cytokines, and reshaping of the epigenetic landscape of target cells. However, th…
View article: Host-Directed Targeting of lincRNA-MIR99AHG Suppresses Intracellular Growth of <i>Mycobacterium Tuberculosis</i>
Host-Directed Targeting of lincRNA-MIR99AHG Suppresses Intracellular Growth of <i>Mycobacterium Tuberculosis</i> Open
View article: Differential Targeting of c-Maf, Bach-1, and Elmo-1 by microRNA-143 and microRNA-365 Promotes the Intracellular Growth of Mycobacterium tuberculosis in Alternatively IL-4/IL-13 Activated Macrophages
Differential Targeting of c-Maf, Bach-1, and Elmo-1 by microRNA-143 and microRNA-365 Promotes the Intracellular Growth of Mycobacterium tuberculosis in Alternatively IL-4/IL-13 Activated Macrophages Open
Mycobacterium tuberculosis (Mtb) can subvert the host defense by skewing macrophage activation toward a less microbicidal alternative activated state to avoid classical effector killing functions. Investigating the molecular basis o…
View article: Beijing genotype dominance among circulating mycobacterium tuberculosis in patients with pulmonary tuberculosis in belarus
Beijing genotype dominance among circulating mycobacterium tuberculosis in patients with pulmonary tuberculosis in belarus Open
Aim and objectives: The surveillance of genetic diversity and genotypes of Mycobacterium tuberculosis (MTB), such as Beijing, Beijing B0/W148 genotypes, T (T1), LAM (LAM 9), U, X, Manu 2, H4, is important for Belarus to evaluate mycobacter…
View article: Transcriptional landscape of Mycobacterium tuberculosis infection in macrophages
Transcriptional landscape of Mycobacterium tuberculosis infection in macrophages Open
View article: Nippostrongylus brasiliensis infection leads to impaired reference memory and myeloid cell interference
Nippostrongylus brasiliensis infection leads to impaired reference memory and myeloid cell interference Open
Hookworm infection is endemic in developing countries, leading to poor cognitive function—among other disruptions. In this study, the effects of Nippostrongylus brasiliensis infection (a murine model of Necator Americanus ) on cognitive fu…
View article: Triptolide Promotes Senescence of Prostate Cancer Cells Through Histone Methylation and Heterochromatin Formation
Triptolide Promotes Senescence of Prostate Cancer Cells Through Histone Methylation and Heterochromatin Formation Open
Background: Triptolide is a medicinal herb-derived diterpene triepoxide with potent anti-tumor activity, mainly ,correlated with its ability to inhibit and inactivate subunits of RNA polymerase II, thereby suppressing global gene transcrip…
View article: IRNdb: The database of immunologically relevant non-coding RNAs
IRNdb: The database of immunologically relevant non-coding RNAs Open
MicroRNAs (miRNAs), long non-coding RNAs (lncRNAs) and other functional non-coding RNAs (ncRNAs) have emerged as pivotal regulators involved in multiple biological processes. Recently, ncRNA control of gene expression has been identified a…
View article: IRNdb: the database of immunologically relevant non-coding RNAs
IRNdb: the database of immunologically relevant non-coding RNAs Open
MicroRNAs (miRNAs), long non-coding RNAs (lncRNAs) and other functional non-coding RNAs (ncRNAs) have emerged as pivotal regulators involved in multiple biological processes. Recently, ncRNA control of gene expression has been identified a…
View article: Redefining the transcriptional regulatory dynamics of classically and alternatively activated macrophages by deepCAGE transcriptomics
Redefining the transcriptional regulatory dynamics of classically and alternatively activated macrophages by deepCAGE transcriptomics Open
Classically or alternatively activated macrophages (M1 and M2, respectively) play distinct and important roles for microbiocidal activity, regulation of inflammation and tissue homeostasis. Despite this, their transcriptional regulatory dy…