Owen Marecic
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View article: Del1 Is a Growth Factor for Skeletal Progenitor Cells in the Fracture Callus
Del1 Is a Growth Factor for Skeletal Progenitor Cells in the Fracture Callus Open
Failure to properly form bone or integrate surgical implants can lead to morbidity and additional surgical interventions in a significant proportion of orthopedic surgeries. While the role of skeletal stem cells (SSCs) in bone formation an…
View article: Articular cartilage regeneration by activated skeletal stem cells
Articular cartilage regeneration by activated skeletal stem cells Open
Osteoarthritis (OA) is a degenerative disease resulting in irreversible, progressive destruction of articular cartilage1. The etiology of OA is complex and involves a variety of factors, including genetic predisposition, acute injury and c…
View article: Geriatric fragility fractures are associated with a human skeletal stem cell defect
Geriatric fragility fractures are associated with a human skeletal stem cell defect Open
Fragility fractures have a limited capacity to regenerate, and impaired fracture healing is a leading cause of morbidity in the elderly. The recent identification of a highly purified bona fide human skeletal stem cell (hSSC) and its commi…
View article: Abstract 58: Multimodal manipulation of the Skeletal Stem Cell for Articular Cartilage Regeneration
Abstract 58: Multimodal manipulation of the Skeletal Stem Cell for Articular Cartilage Regeneration Open
PURPOSE: With an aging population, degenerative diseases such as osteoarthritis are expected to increase. Hyaline cartilage has a poor propensity to regenerate. To ameliorate its healing capacity patients are being offered multiple “stem c…
View article: Shifting Skeletal Stem Cell Dynamics Underlie Skeletal Aging in Mice
Shifting Skeletal Stem Cell Dynamics Underlie Skeletal Aging in Mice Open
Marecic, Owen; McArdle, Adrian; Seo, Elly; Tevlin, Ruth MB, BAO, BCh, MRCSI; Gulati, Gunsagar S.; Murphy, Matthew P. MB, BCh, BAO, MRCSI; Lopez, Michael; Weissman, Irving L. MD; Chan, Charles K. PhD; Longaker, Michael T. MD, MBA, FACS Auth…
View article: Pharmacological rescue of diabetic skeletal stem cell niches
Pharmacological rescue of diabetic skeletal stem cell niches Open
Local delivery of a missing growth factor to the skeletal stem cell niche restores bone healing in diabetic mice.
View article: Murine Dermal Fibroblast Isolation by FACS
Murine Dermal Fibroblast Isolation by FACS Open
Fibroblasts are the principle cell type responsible for secreting extracellular matrix and are a critical component of many organs and tissues. Fibroblast physiology and pathology underlie a spectrum of clinical entities, including fibrose…
View article: Identification and characterization of an injury-induced skeletal progenitor
Identification and characterization of an injury-induced skeletal progenitor Open
Significance Here, we characterize the injury-induced activation of a specific, highly purified population of multipotent skeletal progenitor cells. These activated progenitors show increased cell frequency, increased viability, and enhanc…
View article: High-Throughput Screening of Surface Marker Expression on Undifferentiated and Differentiated Human Adipose-Derived Stromal Cells
High-Throughput Screening of Surface Marker Expression on Undifferentiated and Differentiated Human Adipose-Derived Stromal Cells Open
Adipose tissue contains an abundant source of multipotent mesenchymal cells termed "adipose-derived stromal cells" (ASCs) that hold potential for regenerative medicine. However, the heterogeneity inherent to ASCs harvested using standard m…
View article: Assessment of Viability of Human Fat Injection into Nude Mice with Micro-Computed Tomography
Assessment of Viability of Human Fat Injection into Nude Mice with Micro-Computed Tomography Open
Lipotransfer is a vital tool in the surgeon's armamentarium for the treatment of soft tissue deficits of throughout the body. Fat is the ideal soft tissue filler as it is readily available, easily obtained, inexpensive, and inherently bioc…