Oxana Eschenko
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View article: Receptor-specific noradrenergic modulation of oscillatory dynamics during non-rapid eye movement sleep in adult male rats
Receptor-specific noradrenergic modulation of oscillatory dynamics during non-rapid eye movement sleep in adult male rats Open
Cortical slow oscillations (SO, ∼1 Hz), which are hallmarks of non-rapid eye movement (NREM) sleep, temporally organize thalamocortical spindles (10-16 Hz) and hippocampal ripples (∼150 Hz), thereby promoting coordinated activity within th…
View article: Differential locus coeruleus–hippocampus interactions during offline states
Differential locus coeruleus–hippocampus interactions during offline states Open
Patterns of locus coeruleus (LC) activity and norepinephrine (NE) release during non-rapid-eye-movement (NREM) sleep suggest a critical role for the LC–NE system in offline modulation of forebrain circuits. NE transmission promotes synapti…
View article: Partial chemogenetic inhibition of the locus coeruleus due to heterogeneous transduction of noradrenergic neurons preserved auditory salience processing in wild‐type rats
Partial chemogenetic inhibition of the locus coeruleus due to heterogeneous transduction of noradrenergic neurons preserved auditory salience processing in wild‐type rats Open
The acoustic startle reflex (ASR) and prepulse inhibition of the ASR (PPI) assess the efficiency of salience processing, a fundamental brain function that is impaired in many psychiatric conditions. Both ASR and PPI depend on noradrenergic…
View article: The Projection-Specific Noradrenergic Modulation of Perseverative Spatial Behavior in Adult Male Rats
The Projection-Specific Noradrenergic Modulation of Perseverative Spatial Behavior in Adult Male Rats Open
Adaptive behavior relies on efficient cognitive control. The anterior cingulate cortex (ACC) is a key node within the executive prefrontal network. The reciprocal connectivity between the locus ceruleus (LC) and ACC is thought to support b…
View article: Altered norepinephrine transmission after spatial learning impairs sleep-mediated memory consolidation in rats
Altered norepinephrine transmission after spatial learning impairs sleep-mediated memory consolidation in rats Open
The therapeutic use of noradrenergic drugs makes the evaluation of their effects on cognition of high priority. Norepinephrine (NE) is an important neuromodulator for a variety of cognitive processes and may importantly contribute to sleep…
View article: Priorities for research on neuromodulatory subcortical systems in Alzheimer's disease: Position paper from the NSS PIA of ISTAART
Priorities for research on neuromodulatory subcortical systems in Alzheimer's disease: Position paper from the NSS PIA of ISTAART Open
The neuromodulatory subcortical system (NSS) nuclei are critical hubs for survival, hedonic tone, and homeostasis. Tau‐associated NSS degeneration occurs early in Alzheimer's disease (AD) pathogenesis, long before the emergence of pathogno…
View article: Altered Norepinephrine Transmission after Spatial Learning Impairs Sleep-Mediated Memory Consolidation in rats
Altered Norepinephrine Transmission after Spatial Learning Impairs Sleep-Mediated Memory Consolidation in rats Open
The therapeutic use of noradrenergic drugs makes the evaluation of their effects on cognition of high priority. Norepinephrine (NE) is an important neuromodulator for a variety of cognitive processes, including memory. The NE transmission …
View article: Feasibility of Canine Adenovirus Type 2 (CAV2) Based Vector for the Locus Coeruleus Optogenetic Activation in Non-Transgenic Rats: Implications for Functional Studies
Feasibility of Canine Adenovirus Type 2 (CAV2) Based Vector for the Locus Coeruleus Optogenetic Activation in Non-Transgenic Rats: Implications for Functional Studies Open
The locus coeruleus norepinephrine (LC-NE) system modulates many visceral and cognitive functions, while LC-NE dysfunction leads to neurological and neurodegenerative conditions such as sleep disorders, depression, ADHD, or Alzheimer’s dis…
View article: The Mammalian Locus Coeruleus Complex—Consistencies and Variances in Nuclear Organization
The Mammalian Locus Coeruleus Complex—Consistencies and Variances in Nuclear Organization Open
Descriptions of the nuclear parcellation of the locus coeruleus complex have been provided in approximately 80 mammal species spanning the phylogenetic breadth of this class. Within the mammalian rostral hindbrain, noradrenergic neurons (r…
View article: Synchronous spiking associated with prefrontal high γ oscillations evokes a 5-Hz rhythmic modulation of spiking in locus coeruleus
Synchronous spiking associated with prefrontal high γ oscillations evokes a 5-Hz rhythmic modulation of spiking in locus coeruleus Open
The prefrontal cortex (PFC) is thought to control activity in the noradrenergic locus coeruleus (LC). Prior anatomical and prefrontal stimulation studies demonstrated the potential for PFC-LC interactions; however, it is unknown what types…
View article: Synchronous spiking associated with high gamma oscillations in prefrontal cortex exerts top-down control over a 5Hz-rhythmic modulation of spiking in locus coeruleus
Synchronous spiking associated with high gamma oscillations in prefrontal cortex exerts top-down control over a 5Hz-rhythmic modulation of spiking in locus coeruleus Open
The brainstem noradrenergic locus coeruleus (LC) is reciprocally connected with the prefrontal cortex (PFC). Strong coupling between LC spiking and depolarizing phase of slow (1 – 2 Hz) waves in the PFC field potentials during sleep and an…
View article: Occurrence of Hippocampal Ripples is Associated with Activity Suppression in the Mediodorsal Thalamic Nucleus
Occurrence of Hippocampal Ripples is Associated with Activity Suppression in the Mediodorsal Thalamic Nucleus Open
Forming reliable memories requires coordinated activity within distributed brain networks. At present, neural mechanisms underlying systems-level consolidation of declarative memory beyond the hippocampal–prefrontal interactions remain lar…
View article: Distinct activity patterns in neuromodulatory centers are associated with differential modulation of cortical low and high gamma oscillations
Distinct activity patterns in neuromodulatory centers are associated with differential modulation of cortical low and high gamma oscillations Open
Neuromodulatory systems are thought to gate cortical neuronal excitability — a generalized state consisting of high frequency (20–200 Hz) local field potential (LFP) oscillations. Stimulating neuromodulatory centers evokes a non-specific r…
View article: Neural activity suppression in the mediodorsal thalamus precedes the occurrence of hippocampal ripples
Neural activity suppression in the mediodorsal thalamus precedes the occurrence of hippocampal ripples Open
Highly synchronized oscillations, or ripples (~200Hz), are generated in the hippocampus (HPC) during awake immobility or non-REM (NREM) sleep and has long been suggested to mediate the hippocampal-cortical communication underlying memory c…
View article: Concurrent multisite recordings and brain imaging: a study of events related system and synaptic memory consolidation
Concurrent multisite recordings and brain imaging: a study of events related system and synaptic memory consolidation Open
Experimental work in animals and humans suggests that various oscillatory patterns, including single or multiple cycle short-lasting episodes, reflect state-changes in self-organizing largescale networks. For instance, patterns like K-comp…
View article: Perisynaptic activity in the prefrontal cortex reflects spontaneous transitions in conscious visual perception
Perisynaptic activity in the prefrontal cortex reflects spontaneous transitions in conscious visual perception Open
In binocular rivalry, our perception alternates spontaneously between mutually exclusive or mixed interpretations, although the physical stimulus remains constant. This enables us to study visual consciousness, as it allows for a dissociat…
View article: The activity of thalamic nucleus reuniens is critical for memory retrieval, but not essential for the early phase of “off-line” consolidation
The activity of thalamic nucleus reuniens is critical for memory retrieval, but not essential for the early phase of “off-line” consolidation Open
Spatial navigation depends on the hippocampal function, but also requires bidirectional interactions between the hippocampus (HPC) and the prefrontal cortex (PFC). The cross-regional communication is typically regulated by critical nodes o…
View article: Locus coeruleus phasic discharge is essential for stimulus-induced gamma oscillations in the prefrontal cortex
Locus coeruleus phasic discharge is essential for stimulus-induced gamma oscillations in the prefrontal cortex Open
The locus coeruleus (LC) noradrenergic (NE) neuromodulatory system is critically involved in regulation of neural excitability via its diffuse ascending projections. Tonic NE release in the forebrain is essential for maintenance of vigilan…
View article: The locus coeruleus is a complex and differentiated neuromodulatory system
The locus coeruleus is a complex and differentiated neuromodulatory system Open
Summary Understanding the forebrain neuromodulation by the noradrenergic locus coeruleus (LC) is fundamental for cognitive and systems neuroscience. The diffuse projections of individual LC neurons and presumably their synchronous spiking …
View article: Ripple-triggered stimulation of the locus coeruleus during post-learning sleep disrupts ripple/spindle coupling and impairs memory consolidation
Ripple-triggered stimulation of the locus coeruleus during post-learning sleep disrupts ripple/spindle coupling and impairs memory consolidation Open
Experience-induced replay of neuronal ensembles occurs during hippocampal high-frequency oscillations, or ripples. Post-learning increase in ripple rate is predictive of memory recall, while ripple disruption impairs learning. Ripples may …