Oya Cingöz
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View article: Inhibition of placental trophoblast fusion by guanylate-binding protein 5
Inhibition of placental trophoblast fusion by guanylate-binding protein 5 Open
Syncytin-1 and Syncytin-2 are envelope glycoproteins encoded by human endogenous retroviruses that have been exapted for the fusion of cytotrophoblast cells into syncytiotrophoblasts during placental development. Pregnancy complications li…
View article: Direct translation of incoming retroviral genomes
Direct translation of incoming retroviral genomes Open
Viruses that carry a positive-sense, single-stranded (+ssRNA) RNA translate their genomes soon after entering the host cell to produce viral proteins, with the exception of retroviruses. A distinguishing feature of retroviruses is reverse …
View article: Supplementary Figure 3 from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers
Supplementary Figure 3 from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers Open
Supplementary Figure 3 from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers
View article: Supplementary Figure 3 from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers
Supplementary Figure 3 from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers Open
Supplementary Figure 3 from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers
View article: Supplementary Figure 4 from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers
Supplementary Figure 4 from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers Open
Supplementary Figure 4 from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers
View article: Supplementary Figure 2 from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers
Supplementary Figure 2 from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers Open
Supplementary Figure 2 from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers
View article: Data from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers
Data from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers Open
Numerous hormonal factors contribute to the lifetime risk of breast cancer development. These include inherited genetic mutations, age of menarche, age of menopause, and parity. Inexplicably, there is evidence indicating that ovariectomy p…
View article: Supplementary Figure 4 from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers
Supplementary Figure 4 from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers Open
Supplementary Figure 4 from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers
View article: Supplementary Figure 1 from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers
Supplementary Figure 1 from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers Open
Supplementary Figure 1 from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers
View article: Supplementary Figure 2 from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers
Supplementary Figure 2 from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers Open
Supplementary Figure 2 from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers
View article: Data from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers
Data from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers Open
Numerous hormonal factors contribute to the lifetime risk of breast cancer development. These include inherited genetic mutations, age of menarche, age of menopause, and parity. Inexplicably, there is evidence indicating that ovariectomy p…
View article: Supplementary Figure 1 from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers
Supplementary Figure 1 from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers Open
Supplementary Figure 1 from Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers
View article: HIV-1 infection causes depletion of monocytic cells through a non-canonical cell death pathway
HIV-1 infection causes depletion of monocytic cells through a non-canonical cell death pathway Open
Programmed cell death is a regulatory mechanism to eliminate infected or damaged cells. Several programmed cell death pathways exist, including apoptosis, necroptosis and pyroptosis, which can be distinguished by the cellular molecules inv…
View article: Vpx enhances innate immune responses independently of SAMHD1 during HIV-1 infection
Vpx enhances innate immune responses independently of SAMHD1 during HIV-1 infection Open
Background The genomes of HIV-2 and some SIV strains contain the accessory gene vpx , which carries out several functions during infection, including the downregulation of SAMHD1. Vpx is also commonly used in experiments to increase HIV-1 …
View article: HIV-1 Is a Poor Inducer of Innate Immune Responses
HIV-1 Is a Poor Inducer of Innate Immune Responses Open
Human immunodeficiency virus type 1 (HIV-1) continues to be a major burden to human health worldwide. How infected cells recognize and respond to HIV-1 infection is important in order to better understand the biology of the virus and the c…
View article: Cyclin-dependent kinase activity is required for type I interferon production
Cyclin-dependent kinase activity is required for type I interferon production Open
Significance Innate immune responses are the first line of defense against pathogens. Upon sensing a pathogen, cells produce IFNs: signaling molecules that activate a diverse array of genes involved in antiviral immunity. Cyclin-dependent …
View article: Cyclin-Dependent Kinase Activity is Required for Type I Interferon Production
Cyclin-Dependent Kinase Activity is Required for Type I Interferon Production Open
Recognition of nucleic acids results in the production of type I interferons (IFN), which activate the JAK/STAT pathway and promote the expression of IFN-stimulated genes (ISG). In a search for modulators of this pathway, we discovered a p…