Ozal Beylerli
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View article: Analysis and Functional Significance of TRAP1 in Glioblastoma
Analysis and Functional Significance of TRAP1 in Glioblastoma Open
Introduction. Glioblastoma exhibits high aggressiveness and complex mechanisms of therapy resistance. Tumor necrosis factor receptor-associated protein 1 (TRAP1) participates in metabolic regulation and tumor cell resistance to apoptosis; …
Identification of non-invasive biomarkers associated with glioma hemorrhage Open
Gliomas are among the most prevalent primary intracranial malignancies, and their management remains complex due to high rates of morbidity and mortality. Hemorrhage within gliomas, although relatively uncommon, can exacerbate disease prog…
View article: Correction: Beylerli et al. MiRNAs as Noninvasive Biomarkers and Therapeutic Agents of Pituitary Adenomas. Int. J. Mol. Sci. 2020, 21, 7287
Correction: Beylerli et al. MiRNAs as Noninvasive Biomarkers and Therapeutic Agents of Pituitary Adenomas. Int. J. Mol. Sci. 2020, 21, 7287 Open
In the original publication [...]
lncRNAs and circRNAs: Emerging Players in Pediatric Medulloblastoma Pathology Open
Medulloblastomas (MBs) are the most common malignant brain tumors in children, marked by aggressive growth, molecular heterogeneity, and a high propensity for cerebrospinal dissemination. Despite advancements in conventional treatments - s…
Interaction between microRNA and KRAS in Glioblastoma Open
Glioblastoma (GBM) characterized byits rapid progression and challengingprognosis, often featuring mutations in the Kirsten rat sarcoma virus (KRAS) gene,which is crucial for numerous cellular signaling mechanisms. Emerging research unders…
Hyponatremia in Neurosurgical Patients Open
Hyponatremia refers to a common and potentially dangerous electrolyte imbalance observed in neurosurgical patients, particularly following traumatic brain injuries, subarachnoid hemorrhages, brain tumors, and pituitary surgeries. The paper…
View article: Donor variability in adipose tissue-derived stem cells: implications for the clinical efficacy of autologous fat grafting
Donor variability in adipose tissue-derived stem cells: implications for the clinical efficacy of autologous fat grafting Open
Autologous fat grafting is a common technique in cosmetic and reconstructive surgery, addressing facial rejuvenation, breast contouring, scar mitigation, and soft tissue corrections. However, clinical outcomes can be inconsistent and unpre…
View article: Bioinformatics Analysis Screening and Identification of Key Biomarkers and Drug Targets in Human Glioblastoma
Bioinformatics Analysis Screening and Identification of Key Biomarkers and Drug Targets in Human Glioblastoma Open
Background: Glioblastoma is the most common type of brain cancer, with a prognosis that is unfortunately poor. Despite considerable progress in the field, the intricate molecular basis of this cancer remains elusive. Aim: The aim of this s…
View article: Effect of mesenchymal stem cell-derived exosomes on the inflammatory response after stroke
Effect of mesenchymal stem cell-derived exosomes on the inflammatory response after stroke Open
Stroke, characterized by sudden onset and significant mortality rates, represents a critical challenge in effectively treating neuroinflammation to improve treatment efficacy. In this context, mesenchymal stem cell (MSC)-derived exosomes h…
View article: The function of astrocytes in cerebral infarction and potential therapeutic approaches
The function of astrocytes in cerebral infarction and potential therapeutic approaches Open
Astrocytes, the most prevalent cells in the central nervous system, significantly contribute to the normal physiological functions of the brain. Following cerebral infarction, these astrocytes undergo activation, transforming into reactive…
View article: Risk Factors for Cerebral Hyperperfusion Syndrome After Combined Revascularization in Adult Patients with Moyamoya Disease
Risk Factors for Cerebral Hyperperfusion Syndrome After Combined Revascularization in Adult Patients with Moyamoya Disease Open
Background: Cerebral hyperperfusion syndrome (CHS) is known as a complication after bypass surgery for Moyamoya disease (MMD). However, the incidence of CHS has not been accurately reported, and there is no consensus on the risk factors as…
CircRNAs in Alzheimer's disease: What are the prospects? Open
Circular RNAs (circRNAs) is a fascinating covalently closed circular non-coding RNA that is abundantly present in the transcriptome of eukaryotic cells. Its versatile nature allows it to participate in a multitude of pathological and physi…
View article: Methods of miRNA delivery and possibilities of their application in neuro-oncology
Methods of miRNA delivery and possibilities of their application in neuro-oncology Open
In the current phase of medical progress, practical neuro-oncology faces critical challenges. These include the quest for and development of innovative methodological approaches, as well as the enhancement of conventional therapies to boos…
Cell-Free miRNAs as Non-Invasive Biomarkers in Brain Tumors Open
Diagnosing brain tumors, especially malignant variants, such as glioblastoma, medulloblastoma, or brain metastasis, presents a considerable obstacle, while current treatment methods often yield unsatisfactory results. The monitoring of ind…
Green Synthesis of Silver Nanoparticles Derived from Papaver rhoeas L. Leaf Extract: Cytotoxic and Antimicrobial Properties Open
In the last few decades, the search for metal nanoparticles as an alternative to cancer treatments and antibiotics has increased. In this article, the spectroscopic (ultraviolet–visible (UV-vis), electron-dispersing X-ray (EDX), and Fourie…
The roles of long noncoding RNAs in atrial fibrillation Open
Atrial fibrillation (AF) is a common cardiac arrhythmia that often occurs in patients with structural heart disease and is a significant cause of morbidity and mortality in clinical settings. AF is typically associated with significant cha…
Are there reliable multiparametric MRI criteria for differential diagnosis between intracranial meningiomas and solitary intracranial dural metastases? Open
Intracranial meningiomas are the most common tumors of the central nervous system (CNS). Meningiomas account for up to 36% of all brain tumors. The incidence of metastatic brain lesions has not been determined. Up to 30% of adult patients …
Advances in transdermal siRNAs delivery: A review of current research progress Open
Small interfering RNA (siRNAs) is a double-stranded RNA molecule which can hybridize with a specific mRNA sequence and block the translation of numerous genes to regulate endogenous genes and to defend the genome from invasive nucleic acid…