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View article: Word Young Leaders of Dementia Roadmap 2024‐2029: Approaches and Global Goals for Dementia Challenges
Word Young Leaders of Dementia Roadmap 2024‐2029: Approaches and Global Goals for Dementia Challenges Open
Background The 2021 WHO report highlights the importance of global planning for dementia. Initiatives that unite and support young leaders and stakeholders from diverse backgrounds in dementia care & research are crucial. The G8 Summit on …
View article: The 2022 symposium on dementia and brain aging in low‐ and middle‐income countries: Highlights on research, diagnosis, care, and impact
The 2022 symposium on dementia and brain aging in low‐ and middle‐income countries: Highlights on research, diagnosis, care, and impact Open
Two of every three persons living with dementia reside in low‐ and middle‐income countries (LMICs). The projected increase in global dementia rates is expected to affect LMICs disproportionately. However, the majority of global dementia ca…
View article: Clearance of interstitial fluid (ISF) and CSF (CLIC) group‐part of Vascular Professional Interest Area (PIA), updates in 2022‐2023. Cerebrovascular disease and the failure of elimination of Amyloid‐β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy
Clearance of interstitial fluid (ISF) and CSF (CLIC) group‐part of Vascular Professional Interest Area (PIA), updates in 2022‐2023. Cerebrovascular disease and the failure of elimination of Amyloid‐β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy Open
This editorial summarizes advances from the Clearance of Interstitial Fluid and Cerebrospinal Fluid (CLIC) group, within the Vascular Professional Interest Area (PIA) of the Alzheimer's Association International Society to Advance Alzheime…
View article: The Nairobi Declaration—Reducing the burden of dementia in low‐ and middle‐income countries (LMICs): Declaration of the 2022 Symposium on Dementia and Brain Aging in LMICs
The Nairobi Declaration—Reducing the burden of dementia in low‐ and middle‐income countries (LMICs): Declaration of the 2022 Symposium on Dementia and Brain Aging in LMICs Open
Delegates of the 2022 Symposium on Dementia and Brain Aging in Low- and Middle-Income Countries, representing over 40 countries, met in Nairobi, Kenya, December 5–9 to highlight advances in dementia prevention, diagnosis, care, and researc…
View article: Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice
Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice Open
Background Slowed clearance of amyloid β (Aβ) is believed to underlie the development of Aβ plaques that characterize Alzheimer’s disease (AD). Aβ is cleared in part by the glymphatic system, a brain-wide network of perivascular pathways t…
View article: Impaired glymphatic function and clearance of tau in an Alzheimer’s disease model
Impaired glymphatic function and clearance of tau in an Alzheimer’s disease model Open
The glymphatic system, that is aquaporin 4 (AQP4) facilitated exchange of CSF with interstitial fluid (ISF), may provide a clearance pathway for protein species such as amyloid-β and tau, which accumulate in the brain in Alzheimer’s diseas…
View article: Non-Invasive MRI of Blood–Cerebrospinal Fluid Barrier Function
Non-Invasive MRI of Blood–Cerebrospinal Fluid Barrier Function Open
View article: IC‐P‐019: DYNAMIC CONTRAST‐ENHANCED MRI TO ASSESS GLYMPHATIC FUNCTION IN THE NL‐F MOUSE MODEL OF ALZHEIMER'S DISEASE
IC‐P‐019: DYNAMIC CONTRAST‐ENHANCED MRI TO ASSESS GLYMPHATIC FUNCTION IN THE NL‐F MOUSE MODEL OF ALZHEIMER'S DISEASE Open
Understanding the various clearance mechanisms of Aβ and tau from the brain is a vital step towards developing new treatment strategies for Alzheimer's Disease. The glymphatic system, a fluid network of exchange between cerebrospinal fluid…
View article: P2‐070: DYNAMIC CONTRAST‐ENHANCED MRI TO ASSESS GLYMPHATIC FUNCTION IN THE NL‐F MOUSE MODEL OF ALZHEIMER'S DISEASE
P2‐070: DYNAMIC CONTRAST‐ENHANCED MRI TO ASSESS GLYMPHATIC FUNCTION IN THE NL‐F MOUSE MODEL OF ALZHEIMER'S DISEASE Open
Understanding the various clearance mechanisms of Aβ and tau from the brain is a vital step towards developing new treatment strategies for Alzheimer's Disease. The glymphatic system, a fluid network of exchange between cerebrospinal fluid…
View article: P3‐189: CHARACTERISING THE ASTROCYTIC PROFILE OF DYSTROBREVIN IN THE BRAIN DURING ALZHEIMER'S DISEASE
P3‐189: CHARACTERISING THE ASTROCYTIC PROFILE OF DYSTROBREVIN IN THE BRAIN DURING ALZHEIMER'S DISEASE Open
Probing clearance mechanisms of Aβ and tau from the brain is a vital step towards understanding Alzheimer's disease(AD) progression and developing new strategies for its treatment. One pathway through which Aβ and tau can be cleared is the…
View article: Study the Longitudinal in vivo and Cross-Sectional ex vivo Brain Volume Difference for Disease Progression and Treatment Effect on Mouse Model of Tauopathy Using Automated MRI Structural Parcellation
Study the Longitudinal in vivo and Cross-Sectional ex vivo Brain Volume Difference for Disease Progression and Treatment Effect on Mouse Model of Tauopathy Using Automated MRI Structural Parcellation Open
Brain volume measurements extracted from structural MRI data sets are a widely accepted neuroimaging biomarker to study mouse models of neurodegeneration. Whether to acquire and analyze data in vivo or ex vivo is a crucial de…
View article: Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study
Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study Open
View article: Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI
Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI Open
The glymphatics system describes a CSF-mediated clearance pathway for the removal of potentially harmful molecules, such as amyloid beta, from the brain. As such, its components may represent new therapeutic targets to alleviate aberrant p…
View article: Author response: Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI
Author response: Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The glymphatics system descri…
View article: IC‐06‐02: NON‐INVASIVE IMAGING OF BRAIN CLEARANCE PATHWAYS USING MULTIPLE ECHO TIME ARTERIAL SPIN LABELLING: AN AQUAPORIN‐4 STUDY
IC‐06‐02: NON‐INVASIVE IMAGING OF BRAIN CLEARANCE PATHWAYS USING MULTIPLE ECHO TIME ARTERIAL SPIN LABELLING: AN AQUAPORIN‐4 STUDY Open
Evidence suggests that impaired rates of clearance increase amyloid-β (Aβ) accumulation in Alzheimer's disease (AD). Brain aquaporin-4 (AQP4) water channels appear to play a key role in Aβ clearance, possibly via the glymphatic pathway. To…
View article: IC‐P‐052: GLYMPHATIC FUNCTION DURING EARLY STAGE AMYLOID PATHOLOGY: DYNAMIC CONTRAST‐ENHANCED MRI IN THE J20 MOUSE MODEL OF ALZHEIMER'S DISEASE
IC‐P‐052: GLYMPHATIC FUNCTION DURING EARLY STAGE AMYLOID PATHOLOGY: DYNAMIC CONTRAST‐ENHANCED MRI IN THE J20 MOUSE MODEL OF ALZHEIMER'S DISEASE Open
The glymphatic system describes a fluid network of exchange between the cerebrospinal fluid (CSF) and interstitial fluid (ISF), facilitating efficient clearance of solutes and waste from the brain, mediated by water channel aquaporin-4 [Il…
View article: In Vivo Imaging of Tau Pathology Using Magnetic Resonance Imaging Textural Analysis
In Vivo Imaging of Tau Pathology Using Magnetic Resonance Imaging Textural Analysis Open
Background: Non-invasive characterization of the pathological features of Alzheimer's disease (AD) could enhance patient management and the development of therapeutic strategies. Magnetic resonance imaging texture analysis (MRTA) ha…
View article: Tissue magnetic susceptibility mapping as a marker of tau pathology in Alzheimer's disease
Tissue magnetic susceptibility mapping as a marker of tau pathology in Alzheimer's disease Open
View article: [IC‐P‐193]: FMRI OF VISUAL STIMULI IN A TAU MODEL OF ALZHEIMER's DISEASE
[IC‐P‐193]: FMRI OF VISUAL STIMULI IN A TAU MODEL OF ALZHEIMER's DISEASE Open
Functional magnetic resonance imaging (fMRI) has been investigated as a possible biomarker of Alzheimer's disease (AD) and differences in fMRI responses have been observed between AD patients and healthy controls.[1] How major molecular co…
View article: [P1–354]: INVESTIGATING GLYMPHATIC FUNCTION DURING EARLY TAU PATHOLOGY USING DYNAMIC CONTRAST‐ENHANCED MRI
[P1–354]: INVESTIGATING GLYMPHATIC FUNCTION DURING EARLY TAU PATHOLOGY USING DYNAMIC CONTRAST‐ENHANCED MRI Open
The glymphatic system describes the cerebrospinal fluid (CSF) and interstitial fluid (ISF) exchange pathway that facilitates efficient clearance of solutes and waste from the brain [1]. Because waste solutes, such as amyloid-β and tau, can…
View article: Comparison of In Vivo and Ex Vivo MRI for the Detection of Structural Abnormalities in a Mouse Model of Tauopathy
Comparison of In Vivo and Ex Vivo MRI for the Detection of Structural Abnormalities in a Mouse Model of Tauopathy Open
With increasingly large numbers of mouse models of human disease dedicated to MRI studies, compromises between in vivo and ex vivo MRI must be fully understood in order to inform the choice of imaging methodology. We investig…
View article: Imaging the accumulation and suppression of tau pathology using multiparametric MRI
Imaging the accumulation and suppression of tau pathology using multiparametric MRI Open
View article: Application of neurite orientation dispersion and density imaging (NODDI) to a tau pathology model of Alzheimer's disease
Application of neurite orientation dispersion and density imaging (NODDI) to a tau pathology model of Alzheimer's disease Open
View article: IC‐P‐159: Imaging the efficacy of microtubule stabilizing agent epothilone d in the rtg4510 mouse model of tauopathy
IC‐P‐159: Imaging the efficacy of microtubule stabilizing agent epothilone d in the rtg4510 mouse model of tauopathy Open
As it climbs to epidemic proportions, Alzheimer's disease(AD) implores therapeutic approaches targeted towards its prodromal phase to arrest the decent into dementia. The aberrant accumulation of microtubule(MT) stabilising protein tau, in…
View article: P1‐029: Imaging the efficacy of microtubule stabilizing agent epothilone d in the rtg4510 mouse model of tauopathy
P1‐029: Imaging the efficacy of microtubule stabilizing agent epothilone d in the rtg4510 mouse model of tauopathy Open
As it climbs to epidemic proportions, Alzheimer's disease (AD) implores therapeutic approaches targeted towards its prodromal phase to arrest the decent into dementia. The aberrant accumulation of microtubule (MT) stabilising protein tau, …
View article: P2‐150: Glymphatic clearance impaired in a mouse model of tauopathy: Captured using contrast‐enhanced MRI
P2‐150: Glymphatic clearance impaired in a mouse model of tauopathy: Captured using contrast‐enhanced MRI Open
Sleep disturbances are associated with Alzheimer's disease (AD). Correspondingly, it has recently been suggested that during sleep, the extra-cellular space increases in volume, allowing clearance of waste solutes from the brain parenchyma…
View article: In vivo imaging of tau pathology using multi-parametric quantitative MRI
In vivo imaging of tau pathology using multi-parametric quantitative MRI Open