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View article: Gene–environment interaction study on the polygenic risk score for neuroticism, childhood adversity, and parental bonding
Gene–environment interaction study on the polygenic risk score for neuroticism, childhood adversity, and parental bonding Open
The present study examines whether neuroticism is predicted by genetic vulnerability, summarized as polygenic risk score for neuroticism (PRS N ), in interaction with bullying, parental bonding, and childhood adversity. Data were derived f…
View article: A Comparison of Methods for Gene-Based Testing That Account for Linkage Disequilibrium
A Comparison of Methods for Gene-Based Testing That Account for Linkage Disequilibrium Open
Controlling the type I error rate while retaining sufficient power is a major concern in genome-wide association studies, which nowadays often examine more than a million single-nucleotide polymorphisms (SNPs) simultaneously. Methods such …
View article: Phylogenetic multilevel meta‐analysis: A simulation study on the importance of modelling the phylogeny
Phylogenetic multilevel meta‐analysis: A simulation study on the importance of modelling the phylogeny Open
Meta‐analyses in ecology and evolution require special attention due to certain study characteristics in these fields. First, the primary articles in these fields usually report results that are observed from studies conducted with differe…
View article: Using information‐theoretic approaches for model selection in meta‐analysis
Using information‐theoretic approaches for model selection in meta‐analysis Open
Meta‐regression can be used to examine the association between effect size estimates and the characteristics of the studies included in a meta‐analysis using regression‐type methods. By searching for those characteristics (i.e., moderators…
View article: Combining information
Combining information Open
Statistical analyses always lead to results that include an imprecision to a degree. Combining information refers to quantitative methods that can synthesize information from multiple sources on the same topic to reach a more precise and g…
View article: An evaluation of a novel approach for clustering genes with dissimilar replicates
An evaluation of a novel approach for clustering genes with dissimilar replicates Open
Clustering the genes is a step in microarray studies which demands several considerations. First, the expression levels can be collected as time-series which should be accounted for appropriately. Furthermore, genes may behave differently …
View article: Phylogenetic multilevel meta-analysis: A simulation study on the importance of modeling the phylogeny
Phylogenetic multilevel meta-analysis: A simulation study on the importance of modeling the phylogeny Open
Meta-analyses in ecology and evolution typically include multiple estimates from the same study and based on multiple species. The resulting dependencies in the data can be addressed by using a phylogenetic multilevel meta-analysis model. …
View article: Polygenic liability for schizophrenia and childhood adversity influences daily‐life emotion dysregulation and psychosis proneness
Polygenic liability for schizophrenia and childhood adversity influences daily‐life emotion dysregulation and psychosis proneness Open
Objective To test whether polygenic risk score for schizophrenia (PRS‐S) interacts with childhood adversity and daily‐life stressors to influence momentary mental state domains (negative affect, positive affect, and subtle psychosis expres…
View article: Interaction between polygenic liability for schizophrenia and childhood adversity influences daily-life emotional dysregulation and psychosis proneness
Interaction between polygenic liability for schizophrenia and childhood adversity influences daily-life emotional dysregulation and psychosis proneness Open
Background The earliest stages of the pluripotent psychopathology on the pathway to psychotic disorders is represented by emotional dysregulation and subtle psychosis expression, which can be measured using the Ecological Momentary Assessm…
View article: 7.3 POLYGENIC RISK FOR SCHIZOPHRENIA MODERATES THE INFLUENCE OF CHILDHOOD ADVERSITY ON DAILY-LIFE EMOTIONAL DYSREGULATION AND PSYCHOSIS PRONENESS
7.3 POLYGENIC RISK FOR SCHIZOPHRENIA MODERATES THE INFLUENCE OF CHILDHOOD ADVERSITY ON DAILY-LIFE EMOTIONAL DYSREGULATION AND PSYCHOSIS PRONENESS Open
status: Published
View article: O4.4. DOES POLYGENIC RISK SCORE FOR SCHIZOPHRENIA MODERATE THE MOMENTARY AFFECTIVE AND PSYCHOTIC REACTIONS TO DAILY-LIFE STRESSORS?
O4.4. DOES POLYGENIC RISK SCORE FOR SCHIZOPHRENIA MODERATE THE MOMENTARY AFFECTIVE AND PSYCHOTIC REACTIONS TO DAILY-LIFE STRESSORS? Open
status: Published
View article: Gene‐based interaction analysis shows <scp>GABA</scp> ergic genes interacting with parenting in adolescent depressive symptoms
Gene‐based interaction analysis shows <span>GABA</span> ergic genes interacting with parenting in adolescent depressive symptoms Open
Background Most gene‐environment interaction studies (G × E) have focused on single candidate genes. This approach is criticized for its expectations of large effect sizes and occurrence of spurious results. We describe an approach that ac…