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View article: Glycolipid nanoparticles target the spleen and detarget the liver without charge
Glycolipid nanoparticles target the spleen and detarget the liver without charge Open
Lipid nanoparticles (LNPs) formulated with a neutral helper lipid can deliver RNA to the liver in humans. However, clinically relevant delivery to other tissues has remained challenging. To avoid the liver, scientists often add antibodies …
View article: <i>In utero</i> lipid nanoparticle delivery achieves robust editing in hematopoietic stem cells
<i>In utero</i> lipid nanoparticle delivery achieves robust editing in hematopoietic stem cells Open
In vivo genome editing for hematologic malignancies is limited by inefficient delivery of genome editors to hematopoietic stem cells (HSC) in the bone marrow. To overcome this limitation, we capitalized on the inherent liver tropism of lip…
View article: Engineering Liver Microtissues for Disease Modeling and Regenerative Medicine
Engineering Liver Microtissues for Disease Modeling and Regenerative Medicine Open
The burden of liver diseases is increasing worldwide, accounting for two million deaths annually. In the past decade, tremendous progress has been made in the basic and translational research of liver tissue engineering. Liver microtissues…